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个人简介

杨宇,上海交通大学医学院分子医学研究院研究员、博士生导师。国家海外高层次青年人才计划和上海市海外高层次人才计划入选者。博士毕业于澳门大学生物医药专业,随后在美国佛罗里达大学谭蔚泓院士课题组从事生物纳米技术和肿瘤免疫治疗领域的博士后研究工作。近年来以临床需求为导向,专注于细胞表面核酸分子工程和基于生物材料的肿瘤免疫与微环境干预和治疗。近5年来,以第一/通讯作者在Chem(3篇)、Sci. Adv.(2篇)、J. Am. Chem. Soc.(4篇)、Angew. Chem. Int. Ed(2篇)、Adv. Mater. (2篇)、Nano Lett.(2篇)、ACS Nano(2篇)、ACS Cent. Sci.(2篇)、 Research、Adv. Drug Deliv. Rev. 等国际高水平学术刊物上发表SCI文章40余篇。论文总引用6000余次,H因子41,多篇论文入选 “ESI高被引论文” ,并入选“全球Top 2%顶尖科学家”榜单。主持国家重点研发计划课题和国自然面上、青年项目等,获得上海市曙光学者(2024)、澳门科技奖研究生科技研发奖(2018)、Baxter China青年研究者奖一等奖(2019),担任中国生物材料学会青年委员会委员、世界中医药学会联合会中药药剂委员会理事,并担任Nano Micro Letters、Exploration和AJPS等期刊青年编委。

研究领域

开发智能化纳米药物递送系统 细胞表面定制化DNA分子工程 肿瘤等疾病的诊断、成像和治疗新策略 肿瘤、炎症等免疫微环境的研究与调控

近期论文

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Ziyi Gu#, Xueliang Liu#, Zhen Qi, Zhou Fang, Yiting Jiang, Yuting Huang, Yongyi Wang*, Lianming Wu*, Yu Yang*. A antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction, Chemical Engineering Journal, 2024. In minor revision. (IF=13.3) Jingqi Chen; Yuqing Li*; Xueliang Liu; Hongyi Li; Jiawei Zhu; Rui Ma; Linxin Tian; Lu Yu; Jiabei Li; Zhuang Liu; Weihong Tan; Yu Yang*. Antigen Spatial Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation. Chem (Cell Press), 2024. In press.(IF=22.8) Dongsheng Mao; Wenxing Li; Xueliang Liu; Jingqi Chen; Dali Wei; Lei Luo; Qianqin Yuan; Yu Yang*; Xiaoli Zhu*; Weihong Tan. Rolling circle amplification-based DNA-enzyme nanostructure for immobilization and functionalization of enzymes. Chem (Cell Press), 2024. In press. (IF=22.8) Shuang Wang#, Xueliang Liu#, Dali Wei#, Huayuan Zhou, Jiawei Zhu, Qing Yu, Lei Luo, Xinfeng Dai, Yiting Jiang, Lu Yu, Yu Yang*, Weihong Tan*. Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy through Copper Overload and Glutathione Depletion, Journal of the American Chemical Society, 2024.In press. (IF=14.4) Yuting Huang#, Xueliang Liu#, Jiawei Zhu#, Zhejie Chen, Lu Yu, Xin Huang, Chuhuang Dong, Jiabei Li, Huayuan Zhou, Yu Yang*, Weihong Tan. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and anti-tumor immune response through alleviating tumor hypoxia, Journal of the American Chemical Society, 2024,146(20):13805-13816. (Cover Paper) (IF=14.4) Dongsheng Mao#, Ziliang Dong, Xueliang Liu, Wenxing Li, Hongyi Li, Chao Gu, Ganghui Chen, Xiaoli Zhu*, Yu Yang*. An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy, Angewandte Chemie International Edition, 2024, 63(7):e202311309. (IF=16.1) Xueliang Liu#, Binghua Chen#, Jingqi Chen#, Xuan Wang, Xinfeng Dai, Yuqing Li, Huayuan Zhou, Lianming Wu*, Zhuang Liu*, Yu Yang*. A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction, Advanced Materials, 2024, 36(2):2308477.(IF=27.4) Wen Qiao#, Jingqi Chen#, Huayuan Zhou, Cegui Hu, Sumiya Dalangood, Hanjun Li, Dandan Yang*, Yu Yang*, Jun Gui*. A Single-Atom Manganese Nanozyme Mn-N/C Promotes Anti-Tumor Immune Response via Eliciting Type I Interferon Signaling, Advanced Science, 2024, e2305979. (IF=14.3) Xin Huang#, Jiawei Zhu#, Chuhuang Dong, YuqingLi, QingYu, Xuan Wang, Zhejie Chen, Jiabei Li, Yu Yang*, HaifangWang*. Polyvalent Aptamer-Functionalized NIR-II Quantum Dots for Targeted Theranostics in High PDL1-Expressing Tumors, ACS Applied Materials & Interfaces, 2024. (IF=9.5) Yiting Jiang#, Zhejie Chen#, Yating Yuan, Linxin Tian, Chuhuang Dong, Wencheng Shen, Jinchao Wei*, Shengpeng Wang*, Yu Yang*, Jia Ge*. Cu–N–C single-atom nanozyme as an ultrasensitive sensing platform for α-glucosidase detection, Materials Today Chemistry, 2024, 41, 102327. (IF=6.7) Jia Ge, Yating Yuan, Hao Yang*, Ruijie Deng, Zhaohui Li*, Yu Yang*. Smartphone-assisted colorimetric sensor based on single-atom Cu–C–N nanozyme for mercury (II) ions detection, Materials Today Chemistry, 2024, 37, 102037. (IF=6.7) Jian Wang#, Jiayi Wang#, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, , Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia*, Xueliang Liu*, Yu Yang*. Universal Antibacterial and Anti-inflammatory Treatment using Prussian Blue Nanozyme, EngMedicine, 2024, 1, 1, 100006. Ying Shen, Rongkai Cai, Liang Wu, Kun Han*, Yu Yang*, Dongsheng Mao*. Programmable intelligent DNA nanoreactors (iDNRs) for in vivo tumor diagnosis and therapy, ChemMedChem. (IF=3.6) Zehua Cheng, Ting Wang, Mai Luo, Sijia Wu, Shiyao Hua,Yuqing Li, Yu Yang, Liang Zou, Jinchao Wei*, Peng Li*. A new luminescent nickel nanocluster with solvent and ion induced emission enhancement toward heavy metal analysis, Biosensors and Bioelectronics, 2024, 264, 116660. (IF=10.7) Xueliang Liu#, Fan Li#, Ziliang Dong, Chao Gu, Dongsheng Mao , Jingqi Chen, Lei Luo, Yuting Huang, Jie Xiao*, Zhanchun Li*, Zhuang Liu*, Yu Yang*. Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment, Science Advances, 2023, 9(31), eadf3329. Highlighted by Nat. Rev. Rheumatol. 2023,19, 606. (IF=13.6) Yuqing Li#, Xueliang Liu#, Lu Yu, Xin Huang, Xuan Wang, Da Han*, Yu Yang*, and Zhuang Liu*. Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy, Journal of the American Chemical Society, 2023,145, 45, 24506–24521. (IF=15.0) Chao Gu#, Xueliang Liu#, Lei Luo, Jingqi Chen, Xiao Zhou, Ganghui Chen, Xin Huang, Lu Yu, Qian Chen, Yu Yang*, and Yang Yang*. Metal-DNA Nanocomplexes Enhance Chemo-dynamic Therapy by Inhibiting Autophagy-Mediated Resistance, Angewandte Chemie International Edition, 2023, 62(50):e202307020. (IF=16.6) Yuqing Li#, Jingqi Chen#, Jinchao Wei, Xueliang Liu, Lu Yu, Linqi Yu*, Ding Ding* and Yu Yang*. Metallic nanoplatforms for COVID-19 diagnostics: versatile applications in the pandemic and post-pandemic era, Journal of Nanobiotechnology, 2023; 21(1):255. (IF=10.2) Ganghui Chen, Dongsheng Mao, Xuan Wang, Jingqi Chen, Chao Gu, Shuqin Huang, Yu Yang*, Fang Zhang* and Weihong Tan. Aptamer-based self-assembled nanomicelle enables efcient and targeted drug delivery, Journal of Nanobiotechnology, 2023, 21(1):415. (IF=10.2) Dandan Yang#, Jingqi Chen#, Yuting Huang#, Ganghui Chen, Xueliang Liu, Xuan Wang, Like Yang, Zhaohui Li, Jie Hu*, Qi Zhou*, Jia Ge*, Yu Yang*. Oxidase-like Fe–N/C single atom nanozyme enables sensitive detection of ascorbic acid and acid phosphatase, Analytica Chimica Acta, 2023,341221. (IF=6.2) Lei Luo, Dandan Yang*, Yu Yang*. New biosensors detect light deep inside the brain. Brain-X, 2023,1,1,e3. Jingqi Chen, Bo Liu, Xuan Wang, Xueliang Liu, Dandan Yang*, Yu Yang*. Constructing artificial nucleobase compilation to enable precise molecular medicine.Chinese Journal of Chemistry, 2023,041(011): 1385-1398. (IF=5.4) Jiayi Wang#, Jiahua Pan#, Yijun Tang, Jingqi Chen, Xiaochen Fei, Wei Xue* and Xueliang Liu*.Advances of hafnium based nanomaterials for cancer theranostics. Frontiers in Chemistry, 2023,11:1283924. (IF=5.5) Dan Wang, Jing Zhang, Zhiyong Huang, Yuhang Yang, Ting Fu, Yu Yang, Yifan Lyu, Jiahui Jiang, Liping Qiu, Zehui Cao, Xiaobing Zhang, Qimin You, Yuankui Lin, Zilong Zhao*, Weihong Tan*. Robust Covalent Aptamer Strategy Enables Sensitive Detection and Enhanced Inhibition of SARS-CoV-2 Proteins, ACS Central Science, 2023, 9(1):72-83. (IF=18.2) Yang Sun, Die Yu, Xinyao Geng, Ding Ding, Yu Yang, Zhuang Liu, Zeyu Xiao, Ruowen Wang*, Weihong Tan*. Artificial Base-Directed In Vivo Assembly of an Albumin-siRNA Complex for Tumor-Targeting Delivery, ACS Applied Materials & Interfaces, 2023, 15, 7, 8872–8883. (IF=9.5) Shujuan Xu, Lei He, Fengming Chen, Wenya Dang, Sitao Xie, Long Li, Cheng Cui*, Yu Yang, Yanlan Liu*, Weihong Tan*. Bioinspired molecular engineering of bivalent aptamers by ligand-induced self-dimerization. Chemical Communications, 2023,59(32):4790-4793. (IF=4.9) Xiaohao Liu#, Dongsheng Mao#, Yuchen Song, Liucun Zhu, Albertina N Isak, Cuicui Lu, Guoli Deng, Feng Chen, Fenyong Sun*, Yu Yang*, Xiaoli Zhu*, Weihong Tan*. Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. Science Advances, 2022, 8(2), eabk0133. (IF=13.6) Yang Sun#, Liuting Mo#, Xiaoxiao Hu#, Die Yu, Sitao Xie, Jianglin Li, Zilong Zhao, Xiaohong Fang, Mao Ye*, Liping Qiu*, Weihong Tan*, Yu Yang*. Bispecific Aptamer-Based Recognition-then-Conjugation Strategy for PD1/PDL1 Axis Blockade and Enhanced Immunotherapy. ACS Nano, 2022,16(12):21129-21138. (IF=17.1) Yao Liu, Jingshan Luo, Yujing Liu, Wen Liu, Guangtao Yu, Yuting Huang, Yu Yang*, Xiaojia Chen*, Tongkai Chen*. Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson's Disease. ACS Central Science, 2022,8(9):1336-1349. (IF=18.2) Yu Yang, Bo Liu, Yuan Liu, Jingqi Chen, Yujia Sun, Xiaoshu Pan, Jun Xu, Shujuan Xu, Zhuang Liu*, Weihong Tan*. DNA-Based MXFs to Enhance Radiotherapy and Stimulate Robust Antitumor Immune Responses. Nano Letters, 2022, 22(7): 2826-2834. (IF= 10.8) Jia Ge, Like Yang, Zhaohui Li, Yi Wan*, Dongsheng Mao, Ruijie Deng, Qi Zhou*, Yu Yang*, Weihong Tan*. A colorimetric smartphone-based platform for pesticides detection using Fe-N/C single-atom nanozyme as oxidase mimetics. Journal of Hazardous Materials, 2022, 436:129199. (IF=13.6) Guowang Cheng#, Xueliang Liu#, Yujing Liu, Yao Liu, Rui Ma, Jingshan Luo, Xinyi Zhou, Zhenfeng Wu*, Zhuang Liu, Tongkai Chen*, Yu Yang*. Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease. Research, 2022, 9781323. (IF=11.0) Jie Hu#, Rui Chen#, Zhenglin Li#, Fenzan Wu, Yanhong Yang, Yu Yang*, Xiaokun Li*, Jian Xia*. Polyphenol-Coordinated Supramolecular Hydrogel as a Promising “One-Stop-Shop” Strategy for Acute Infected Wound Treatment. Applied Materials Today, 2022,29.101586. (IF=8.3) Zehua Cheng, Jinchao Wei, Liqiang Gu, Liang Zou, Ting Wang, Ling Chen, Yuqing Li*, Yu Yang, Peng Li*. DNAzyme-based biosensors for mercury (Ⅱ) detection: Rational construction, advances and perspectives. Journal of Hazardous Materials, 2022:128606. (IF=13.6) Dongsheng Mao, Cuicui Lu, Runchi Zhang, Liucun Zhu, Yuchen Song, Chang Feng, Qianqian Zhang, Tianshu Chen, Yu Yang, Guifang Chen*, Xiaoli Zhu*, Weihong Tan*. Computer-Aided Design of DNA Self-Limited Assembly for Relative Quantification of Membrane Proteins. Analytical Chemistry, 2022, 94(28):10263-10270. (IF=7.4) Mengze Xu, Yu Yang, Zhen Yuan*. Breast Cancer Cell Membrane Camouflaged Lipid Nanoparticles for Tumor-Targeted NIR-II Phototheranostics. Pharmaceutics, 2022,14(7):1367.(IF=5.4) Yu Yang, Jun Xu, Yang Sun, Liuting Mo, Bo Liu, Xiaoshu Pan, Zhuang Liu*, Weihong Tan*. Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy. Journal of the American Chemical Society, 2021, 143, 22, 8391–8401. (IF= 16.383) Renyikun Yuan#, Yuqing Li#, Shan Han#, Xinxin Chen, Jingqi Chen, Jia He, Hongwei Gao*, Yang Yang*, Shilin Yang, Yu Yang*. Fe-Curcumin Nanozyme-mediated ROS Scavenging and Anti-inflammation for Acute Lung Injury. ACS Central Science (Cover Paper), 2021, 8(1): 10-21. (IF= 18.728) Bo Liu, Yu Yang*, Yu Chao, Zhisheng Xiao, Jialu Xu, Chunjie Wang, Ziliang Dong, Linqian Hou, Qiaofeng Li, Zhuang Liu*. Equipping cancer cell membrane vesicles with functional DNA as a targeted-vaccine for cancer immunotherapy. Nano letters, 2021, 21(22):9410-9418. (IF= 12.262) Yu Yang*, Hao Wu, Bo Liu, Zhuang Liu*. Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment. Advanced Drug Delivery Reviews, 2021,179, 114004. (IF= 17.873) Jia Ge*, Yanmei Shen, Weixia Wang, Yuqing Li*, Yu Yang*. N-doped carbon dots for highly sensitive and selective sensing of copper ion and sulfide anion in lake water. Journal of Environmental Chemical Engineering, 2021, 9(2), 105081. (IF=7.968) Zhejie Chen, Mohamed A. Farag, Zhangfeng Zhong, Chen Zhang, Yu Yang, Shengpeng Wang*, Yitao Wang*. Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems. Advanced Drug Delivery Reviews, 2021 ,176:113870. (IF=17.837) Yu Yang, Zhuang Liu*. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy. Chem (Cell Press), 2020, 6 (9): 2127-2129. (IF= 22.804) Yu Yang, Xiaoqi Sun, Jun Xu, Cheng Cui*, Hoda Safari Yazd, Xiaoshu Pan, Yujie Zhu , Xigao Chen, Xiaowei Li, Jin Li, Weihong Tan* Circular bispecific Aptamer-mediated targeted cellular immunotherapy. ACS Nano, 2020, 14(8): 9562-9571. (IF= 15.881) Yu Yang, Wenjun Zhu, Liang Cheng, Ren Cai, Xuan Yi, Jiaxuan He, Xiaoshu Pan, Lu Yang, Kai 30. Yang, Zhuang Liu, Weihong Tan*, Meiwan Chen*. Tumor microenvironment (TME)-activatable circular aptamer-PEG as an effective hierarchical-targeting molecular medicine for photodynamic therapy.Biomaterials, 2020, 246: 119971. (IF=12.479) Yu Yang#, Jiaxuan He#, Wenjun Zhu, Xiaoshu Pan, Hoda Safari Yazd, Cheng Cui, Lu Yang, Xiaowei Li, Long Li, Liang Cheng, Liangzhu Feng, Ruowen Wang, Zhuang Liu*, Meiwan Chen*, Weihong Tan*. Molecular domino reactor built by automated modular synthesis for cancer treatment. Theranostics, 2020:10 (9), 4030 (IF=11.556) Xiaoshu Pan#, Yu Yang#, Long Li, Xiaowei Li, Qiang Li, Cheng Cui*, Bang Wang, Hailan Kuai, Jianhui Jiang, Weihong Tan*. A bispecific circular aptamer tethering built-in universal molecular tag for functional protein delivery. Chemical Sciences, 2020, 11(35): 9648-9654. (IF=9.825) Hoda Safari Yazd#, Yu Yang#, Long Li, Lu Yang, Xiaowei Li, Xiaoshu Pan, Zhuo Chen, Jianhui Jiang, Cheng Cui, Weihong Tan*. Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery. iScience, 2020, 23(12):101750. (IF=5.458) Xiaowei Li, Yu Yang, Hengzhi Zhao, Tian Zhu, Zhihui Yang, Haiyan Xu, Yueqiang Fu, Fan Lin, Xiaoshu Pan, Long Li, Cheng Cui, Min Hong, Lu Yang, Kevin K. Wang*, Weihong Tan*. Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy. Journal of the American Chemical Society, 2020,142(8):3862-3872. (IF=15.419) Xianwen Wang, Linxin Fan, Liang Cheng*, Yanbin Sun, Xiyu Wang, Xiaoyan Zhong, Qianqian Shi, Fei Gong, Yu Yang, Yan Ma, Zhaohua Miao, Zhengbao Zha*. Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy. iScience, 2020, 23(7):101281. (IF=5.458) Yujia Sun, Liwei Zheng, Yu Yang, Xu Qian, Ting Fu*, Xiaowei Li, Zunyi Yang, He Yan, Cheng Cui*, Weihong Tan*. Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications. Nano micro letters, 2020,12(1):103. (IF=16.419)

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