Zeidler, Martin - University of Sheffield - Department of Biomedical Science

个人简介

2007-present: Reader, University of Sheffield, UK. 2006-2007: Senior Lecturer, University of Sheffield, UK. 2001-2006: Emmy Noether Independent Group Leader, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. 1996-2001: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Boston, MA, USA 1991-1996: Pre-doctoral student at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. 1987-1991: BSc in Biology with European Studies (German), The University of Sussex, Brighton, UK.

研究领域

My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies. We use both high throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.

近期论文

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Fisher KH, Stec W, Brown S & Zeidler MP (2016) Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran. Molecular Biology of the Cell, 27(3), 434-441. View this article in WRRO Thomas S, Fisher K, Snowden J, Danson S, Brown S & Zeidler M (2015) Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. The Lancet, 385, S98-S98. Thomas SJ, Snowden JA, Zeidler MP & Danson SJ (2015) The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours. British Journal of Cancer, 113(3), 365-371. View this article in WRRO Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) Methotrexate Is a JAK/STAT Pathway Inhibitor. PLOS ONE, 10(7), e0130078-e0130078. View this article in WRRO Bausek N & Zeidler MP (2013) Gα73Β is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci. Zeidler MP & Bausek N (2013) The Drosophila JAK-STAT pathway. JAK-STAT, 2(3). Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.. Development, 140(18), 3858-3868. Stec W, Vidal O & Zeidler MP (2013) Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.. Mol Biol Cell, 24(18), 3000-3009. View this article in WRRO Johnstone K, Wells RE, Strutt D & Zeidler MP (2013) Localised JAK/STAT pathway activation is required for Drosophila wing hinge development.. PLoS One, 8(5), e65076. View this article in WRRO