Winder, Steve - University of Sheffield - Department of Biomedical Science

个人简介

Present: Professor of Molecular Cell Biology, Department of Biomedical Science, Department, University of Sheffield, Sheffield UK 2003-2005: Reader, Department of Biomedical Science, University of Sheffield, Sheffield UK 1999-2003 : Lecturer (99-01) Reader (02-03), University of Glasgow 1995-1999 : Wellcome Trust Fellow, University of Edinburgh, 1992-1995 : Staff Scientist, Laboratory of Molecular Biology, Cambridge - Advisor, Jake Kendrick-Jones 1988-1992: Postdoctoral Fellow, Biochemistry, University of Calgary, Advisor - Mike Walsh. 1994-1998 : PhD, University of Reading, Supervisor - Isabel Forsyth

研究领域

The main research focus of my group is centered around understanding the normal functions of the cell adhesion and signalling adaptor protein dystroglycan and in diseases such as muscular dystrophy and cancer. In particular we are investigating the regulation of the actin cytoskeleton, adhesion mediated signalling and cell motility and invasion using molecular cell biology and transgenic approaches.

近期论文

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Leocadio D, Mitchell A & Winder SJ (2016) γ-Secretase Dependent Nuclear Targeting of Dystroglycan. Journal of Cellular Biochemistry, n/a-n/a. Lipscomb L, Piggott RW, Emmerson T & Winder SJ (2016) Dasatinib as a treatment for Duchenne muscular dystrophy. Human Molecular Genetics, 25(2), 266-274. View this article in WRRO Escárcega-Tame MA, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2015) Dystroglycan Depletion Impairs Actin-Dependent Functions of Differentiated Kasumi-1 Cells. PLOS ONE, 10(12), e0144078-e0144078. View this article in WRRO Tetlow DJ, Winder SJ & Aïssa C (2015) The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton. Chem. Commun., 52(4), 807-810. Leiton CV, Aranmolate A, Eyermann C, Menezes MJ, Escobar-Hoyos LF, Husain S, Winder SJ & Colognato H (2015) Laminin promotes metalloproteinase-mediated dystroglycan processing to regulate oligodendrocyte progenitor cell proliferation. Journal of Neurochemistry, 135(3), 522-538. Cerecedo D, Martínez-Vieyra I, Maldonado-García D, Hernández-González E & Winder SJ (2015) Association of Membrane/Lipid Rafts With the Platelet Cytoskeleton and the Caveolin PY14: Participation in the Adhesion Process. Journal of Cellular Biochemistry, 116(11), 2528-2540. Martínez-Zárate AD, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2014) Dystroglycan depletion inhibits the functions of differentiated HL-60 cells. Biochemical and Biophysical Research Communications, 448(3), 274-280. Martínez-Zárate AD, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2014) Dystroglycan depletion inhibits the functions of differentiated HL-60 cells.. Biochem Biophys Res Commun, 448(3), 274-280. Singh SM, Bandi S, Winder SJ & Mallela KMG (2014) The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry, 53(11), 1801-1809. Mathew G, Mitchell A, Down JM, Jacobs LA, Hamdy FC, Eaton C, Rosario DJ, Cross SS & Winder SJ (2013) Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer.. Sci Rep, 3, 2792. View this article in WRRO