Eeden, Freek Van - University of Sheffield - Department of Biomedical Science

个人简介

2006- present: Senior Lecturer, University of Sheffield 1999 - 2005: Junior Group Leader Hubrecht Laboratory, Utrecht, The Netherlands 1997 - 1999: Post-doctoral worker, D. StJohnston Lab, Wellcome/CRC Inst. Cambridge UK 1992 - 1997: PhD, C. Nüsslein-Volhard Lab. Max Planck Inst. für Entwicklungsbiologie, Tübingen, Germany 1986 - 1992 MSc. Wageningen Agricultural University, The Netherlands

研究领域

Using the zebrafish as a genetic tool to study development and disease. We are interested in understanding the role of the patched genes in Hedgehog signaling. In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish.

近期论文

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Savage AM, Mayo C, Kim HR, Markham E, van Eeden FJM, Chico TJA & Wilkinson RN (2016) GENERATION AND CHARACTERISATION OF NOVEL TRANSGENIC ZEBRAFISH ALLOWING IN VIVO IMAGING OF ENDOTHELIAL CELL BIOLOGY. ATHEROSCLEROSIS, 244, E10-E10. Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S & van Eeden FJ (2015) Genome-wide mapping of Hif-1α binding sites in zebrafish. BMC Genomics, 16(1). Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M. K. Rothman A, Elworthy S, van Eeden FJM & Chico TJA (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLOS ONE, 10(10), e0141611-e0141611. View this article in White Rose Research Online Elks PM, Renshaw SA, Meijer AH, Walmsley SR & van Eeden FJ (2015) Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models. Disease Models & Mechanisms, 8(11), 1349-1360. Njegic AM, Chico TJA, van Eeden FJ & Watson OJ (2015) The effect of macrophage depletion on hypoxia signalling induced angiogenesis in zebrafish. Atherosclerosis, 244, E8-E9.