Smythe, Carl - University of Sheffield - Department of Biomedical Science

个人简介

2002 – present: Professor of Cell Biology, Department of Biomedical Science, University of Sheffield 2004 – 2006: Head of Department, Department of Biomedical Science, University of Sheffield 1992 – 2002: Principal Investigator at MRC Protein Phosphorylation Unit, University of Dundee 1989 – 1992: American Cancer Society Senior Research Fellow, University of California, San Diego 1985 – 1989: British Diabetic Association postdoctoral research assistant at MRC Protein Phosphorylation Group at University of Dundee 1981 – 1985: PhD Department of Biochemistry, Trinity College, University of Dublin

研究领域

Chromosome Integrity - Chromosomes in eukaryotes control their environment to ensure that genomic integrity is maximised. We are interested in understanding mechanisms of genomic integrity operating at the molecular and cellular level, and determining the consequences when they fail.

近期论文

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Gotham VJB, Hobbs MC, Burgin R, Turton D, Smythe C & Coldham I (2016) Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. Org. Biomol. Chem., 14(5), 1559-1563. View this article in White Rose Research Online Block K et al. (2015) Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology, 35, S276-S304. Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M. K. Rothman A, Elworthy S, van Eeden FJM & Chico TJA (2015) klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLOS ONE, 10(10), e0141611-e0141611. View this article in White Rose Research Online Wragg A, Gill MR, McKenzie L, Glover C, Mowll R, Weinstein JA, Su X, Smythe C & Thomas JA (2015) Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal-Complex-Based DNA Imaging Probes. Chemistry - A European Journal, 21(33), 11865-11871. Wragg A, Gill MR, Hill CJ, Su X, Meijer AJHM, Smythe C & Thomas JA (2014) Dinuclear osmium( ii ) probes for high-resolution visualisation of cellular DNA structure using electron microscopy. Chem. Commun., 50(93), 14494-14497. Wragg A, Gill MR, Turton D, Adams H, Roseveare TM, Smythe C, Su X & Thomas JA (2014) Tuning the Cellular Uptake Properties of Luminescent Heterobimetallic Iridium(III)-Ruthenium(II) DNA Imaging Probes. Chemistry - A European Journal, 20(43), 14004-14011.