个人简介
2012-present: Lecturer
2006-2010: Principal Investigator, University of Cambridge (MRC Career Development Award).
2001-2005: Postdoctoral fellow, Genentech Inc.,.
2000-2001: Postdoctoral fellow, Stanford University (Wellcome Trust Research Fellowship).
1995-1999: PhD, University of Cambridge.
1991-1995: BSc., University of Edinburgh.
研究领域
Constitutive secretion is a conserved process required for the delivery of newly synthesised proteins and lipids to plasma membrane as well as the exocytocis of extracellular factors such as cytokines, lipoproteins and antibodies. My lab is interested in identifying and characterising the pathways and machinery involved in constitutive secretion.
近期论文
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Zlatic SA, Grossniklaus EJ, Ryder PV, Mattheyses AL, Faundez V, Salazar G & Peden AA (2013) Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis. Molecular Biology of the Cell, 24(15), 2378-2388.
Kent HM, Evans PR, Schäfer IB, Gray SR, Sanderson CM, Luzio JP, Peden AA & Owen DJ (2012) Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex. Developmental Cell, 22(5), 979-988.
Miller SE, Sahlender DA, Graham SC, Höning S, Robinson MS, Peden AA & Owen DJ (2011) The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell, 147(5), 1118-1131.
Wendler F, Franch-Marro X, Vincent J-P, Gillingham AK, Sinka R, Rosa-Ferreira C, Munro S, Gordon DE & Peden AA (2010) A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. EMBO Journal, 29(2), 304-314.