Nassar, Mohammed - University of Sheffield - Department of Biomedical Science

个人简介

2010-present: Lecturer, dept. of Biomedical Sciences, Sheffield University, UK. 1999-2009: Senior postdoctoral Fellow, Molecular Nociception Group, Dept. of Biology, UCL, UK. 1998-99: Postdoctoral Fellow (Wellcome Prize Fellowship), Wellcome Laboratory for Molecular Pharmacology, Dept. of Pharmacology, UCL, UK. 1994-98: Postgraduate student (Wellcome Prize studentship), Wellcome Laboratory for Molecular Pharmacology, Dept. of Pharmacology, UCL, UK. 1994: Research assistant in the Wellcome Laboratory for Molecular Pharmacology, Dept. of Pharmacology, UCL, UK. 1993: Research assistant in Dept. of Bacteriology, Belfast City Hospital, UK.

研究领域

My research is focused on primary sensory neurons which are part of the peripheral nervous system (PNS). Sensory neurons convey sensory information from the both internal (e.g. viscera, muscles and bones) and external (skin) environments to the central nervous system (CNS). Sensory neurons convey both innoxious and noxious stimuli. The latter is perceived in the CNA as pain. My research interest lies in investigating the molecular changes in sensory neurons that are associated with pathological pain. This is important in order to identify potential targets for new, effective yet specific targets for analgesic drugs. My lab uses variety of methods based on molecular biology and cellular biology to investigate potential targets. The Nav1.7 sodium channel has been shown by us and others to be crucial in pain signalling. Loss and gain of function mutations in humans lead to complete insensitivity to pain and painful disorders, respectively. Despite this, little is known about its trafficking in sensory neurons or the proteins that regulate it. These proteins, once identified, can serve as targets for novel analgesic drugs. I have identified several proteins that interact with Nav1.7 channel and my lab is investigating not only their role in Nav1.7 trafficking but also in the excitability of sensory neurons. My lab has also generated a new in vitro model of sensory neurons (named the MED cell lines). We immortalised sensory neuron progenitors and are able to differentiate them in vitro to a sensory neurons-like phenotype. These cell lines may provide a platform for both academic and pharmaceutical research to carry out screens aimed at target identification and validation.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Nassar M, Christian Weidner , Peter W Reeh & Tal Hoffmann (2016) Use dependence of peripheral nociceptive conduction in the absence of TTXr sodium channel subtypes. Journal of Physiology. Deuis J, Wingerd J, Winter Z, Durek T, Dekan Z, Sousa S, Zimmermann K, Hoffmann T, Weidner C, Nassar M, Alewood P, Lewis R & Vetter I (2016) Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins, 8(3), 78-78. Denk F, Ramer LM, Erskine ELKS, Nassar MA, Bogdanov Y, Signore M, Wood JN, McMahon SB & Ramer MS (2015) Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathologica Communications, 3(1). Doran C, Chetrit J, Holley MC, Grundy D & Nassar MA (2015) Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6), e0128670-e0128670. View this article in White Rose Research Online Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw AL, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH & Bulmer DC (2014) Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli. Pain, 155(10), 1962-1975. Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJG, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM & Rorsman P (2014) Na⁺ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. Journal of Physiology, 592(21), 4677-4696. Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH & Bulmer DC (2014) Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli.. Pain, 155(10), 1962-1975.