个人简介
赵洪友博士长期从事新型医用光敏药物的研发和临床前评价,激光诊疗设备的研发以及光动力治疗肿瘤的机制研究。由顾瑛院士牵头,赵洪友博士主要负责的国内第一个新型二氢卟吩类光敏药物KAE已经完成临床前功能与安全性评价,即将开展临床试验。参与研发的 “倍频Nd:YV04激光光动力治疗仪” 已获国家食品药品监督管理局三类医疗器械认证(国食药监械(准)字2013第3240155号),光学相干成像仪已获北京食品药品监督管理局二类器械认证(京食药监械(准)字2014第2241232号)。以第一/通讯作者在国际医学期刊 Eur. J. Cancer 发表封面文章1篇;国际医用化学期刊 J. Med. Chem. J Mater. Chem. B ;在国际生物光子学期刊J. Photochem. and Photobio. B, Photodiagnosis Photodyn. Ther.等杂志发表论文多篇。
教育培训经历
2011. 09-2014. 07 解放军总医院 激光医学 博士研究生
2008. 09-2011. 07 华南师范大学 生物医学光子学 硕士研究生
2004. 09-2008. 07 内蒙古大学 生物学 本科
工作经历
2020.01-现在 北京理工大学,医学技术学院, 特别副研究员
2016.09-2019. 03 美国路易斯安那州州立大学,癌症研究中心 博士后
2014.08-2016. 08 美国南阿拉巴马大学,米切尔癌症研究中 博士后
研究领域
可逆光酸治疗肿瘤的机制研究; 新型光敏剂的研发以及临床前的系统评价; 无创光疗治疗阿尔茨海默症的谱效与量效关系研究
近期论文
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Hongyou Zhao*, Haolin Liu, Lin Kang, Tianzhen Sun, Yidi Liu, Defu Chen and Ying Gu* et al. In vitro and in vivo evaluation of a chlorin-based photosensitizer KAE? for cancer treatment. Photodiagnosis Photodyn Ther. 2022. doi: https://doi.org/10.1016/j. pdpdt.
Hongyou Zhao, Tengda Ji, Tianzhen Sun, Haolin Liu, Yidi Liu, Haixia Qiu and Ying Gu* et al. “Comparative study on photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo” J. Innov. Opt. Heal. Sci. 2022. 15: 2250010-1-2250010-10.
Hongyou Zhao, Yi Bin, Zhipin Liang, Adam I. Riker, and Yaguang Xi* et al. “Cyclin G2, a novel target of sulindac to inhibit cell cycle progression in colorectal cancer” Genes & Diseases. 2021. 8: 320-330.
Li-Peng Zhang, Xianqiang Li, Hongyou Zhao*, Lin Kang Tianlong Liu and Yuxia Zhao* et al. “Ultra-high photoactive thiadiazolo [3,4-g] quinoxaline nanoparticles with active-targeting capability for deep photodynamic therapy” J. Mater. Chem. B. 2021. 9: 8330–8340.
Hongyou Zhao, Rong Yin, Ying Wang, Ying Gu* et al. Modulating mitochondrial morphology enhances antitumor effect of 5-ALA-mediated photodynamic therapy both in vitro and in vivo. J. Photochem. and Photobio. B. 2017. 176: 81-91.
Qianli Zou#, Hongyou Zhao#, Yuxia Zhao, Ying Gu*, et al. Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers. J. Med. Chem. 2015, 58:7949?7958.
Hongyou Zhao, Rong Yin, Ying Wang, Ying Gu* et al. In vitro and in vivo antitumor activity of a novel hypocrellin B derivative for photodynamic therapy. Photodiagnosis Photodyn. Ther. 2014, 11: 204-212.
Hongyou Zhao, Yucheng Wang, Haixia Qiu, Ying Gu*. 2014. Photodynamic therapy and anti-tumor immunity. Chinese Journal of Laser Medicine & Surgery, 2014, 23:34-38.
Hongyou Zhao, Qun Chen, Da Xing*. 2011. New insights of mitochondria reactive oxygen species generation and cell apoptosis induced by low dose photodynamic therapy. Eur. J. Cancer, 2011, 47:2750-2761.
EI Journal paper
Hongyou Zhao, Bin Yi, Ruixia Ma and Yaguang Xi. MiR-182 is involved in sulindac anticancer activity in colon cancer. 2017 AACR Annual Meeting: Research Propelling Cancer Prevention and Cures. Washington, D.C
Hongyou Zhao, Bin Yi, Hong Chang, Zhipin Liang, Ruixia Ma and Yaguang Xi. Sulindac inhibition of colon tumor cell growth through miR-182/FOXO3a/CyclinG2 signaling. 2016 AACR Precision Medicine Series: Cancer Cell Cycle-Tumor Progression and Therapeutic Response. Orlando FL.
Hongyou Zhao, Jie Ren, Rong Yin, Ying Wang, Ying Gu. The mechanism of apoptosis induced by photodynamic therapy. 2012 SPIE-Photonics Asia Meeting. Beijing.
中文论文
刘浩林,邱海霞,曾晶,赵洪友*,顾瑛* 新型二氢卟吩类光敏剂KAE介导的光动力疗法对HeLa细胞的杀伤作用,激光医学杂志,2022 DOI:10.13480/j.issn1003-9430.2021.0301
赵洪友;王钰铖;邱海霞;顾瑛* 光动力治疗与抗肿瘤免疫, 激光医学杂志,2 014,23,34-38
学术兼职
中华医学会激光医学分会委员
北京医学会激光医学分会委员
同时还担任J. Photochem. and Photobio. B, Photodiagnosis Photodyn. Ther.等多个国际学术期刊审稿人