Humphreys, Daniel - University of Sheffield - Department of Biomedical Science

个人简介

2016: Lecturer 2014 - 2016: Research Fellow and Principal Investigator, University of Cambridge 2008 - 2013: Postdoctoral Research Associate, University of Cambridge 2003 - 2007: PhD, University of Cambridge 2002 - 2003: Masters of Biological Research, University of Manchester 1999 - 2002: Bachelors of Science, University of Liverpool

研究领域

Manipulation of mammalian host cell biology by bacterial toxins and virulence effectors To establish infections within mammalian hosts, bacterial pathogens have evolved sophisticated strategies to exploit host cell biology. They deploy toxins and virulence effector proteins into our cells that hijack cellular processes to promote pathogen survival, replication and dissemination, and interfere with the host immune response. We are interested in the cell biology subverted by bacterial pathogens and how this ultimately contributes to diseases that can have devastating consequences to the health of humans and animals. Understanding host-pathogen interactions is especially important when considering the human health threat posed by many bacterial pathogens that continue to develop multidrug resistance.

近期论文

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Humphreys D*. Singh V, Koronakis V*. (2016). Inhibition of WAVE Regulatory Complex activation by a bacterial virulence effector counteracts pathogen phagocytosis. Cell Reports. 17 (3) 697-707. *co-corresponding authors. http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31278-5 Davidson AC., Humphreys D., Brooks, ABE., Hume, PJ., and Koronakis V. (2015). The Arf GTPase-Activating Protein family is exploited by Salmonella enterica serovar Typhimurium to invade non-phagocytic host cells. mBio. 6(1):e02253-14. PMID 25670778 Hume, PJ., Humphreys, D., and Koronakis, V. (2014). WAVE Regulatory complex activation at the membrane. Methods in Enzymology. 540, 363-79. PMID: 24630117 Humphreys D, Davidson AC, Hume PJ, Makin LE, Koronakis V. (2013) Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16880-16885. PMID: 24085844 Humphreys, D., Liu T, Davidson, AC., Hume, PJ., and Koronakis V. (2012) Drosophila Arf1 homologue Arf79F is essential for lamellipodia formation. Journal of Cell Science 125, 5621-5629. PMID: 22992458 Humphreys D, Davidson AC, Hume PJ, Koronakis V. (2012) Salmonella SopE and host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.