Holley, Matthew - University of Sheffield - Department of Biomedical Science

个人简介

2001-present: Professor of Sensory Physiology, University of Sheffield 2013-2016: Director of Undergraduate Studies 2006-2012: Head of Department 2000-2001: Reader, Department of Physiology, University of Bristol 1990-2000: Royal Society University Research Fellow, Department of Physiology, University of Bristol 1988-1990: Beit Memorial Research Fellow, Department of Physiology, University of Bristol 1986-1988: Post-doctoral Research Associate (MRC), Department of Physiology, University of Bristol 1985-1986: Brown Junior Research Fellow, The Queen's College, University of Oxford 1984-1985: Royal Society European Exchange Programme Fellow, Department of Cell Biology, University of Stockholm, Sweden 1983: D.Phil - University of Oxford 1982-1984: Brown Junior Research Fellow, The Queen's College, University of Oxford 1979-1982: Postgraduate Research Student, Department of Zoology, University of Oxford 1979: BSc.Hons - University of Newcastle-upon-Tyne

研究领域

I am primarily interested in the development and function of the mammalian inner ear with a focus on potential treatments for hearing loss. I have developed in vitro models for the differentiation of sensory hair cells and sensory nerves and use them in conjunction with microarrays to study gene networks centred on the transcription factor Gata3. I have also explored a model system for cell transplantation into the inner ear in vivo.

近期论文

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Sekiya T, Holley MC, Hashido K, Ono K, Shimomura K, Horie RT, Hamaguchi K, Yoshida A, Sakamoto T & Ito J (2015) Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration. Proceedings of the National Academy of Sciences, 112(26), E3431-E3440. View this article in White Rose Research Online Doran C, Chetrit J, Holley MC, Grundy D & Nassar MA (2015) Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6), e0128670-e0128670. View this article in White Rose Research Online Zampini V, Johnson SL, Franz C, Knipper M, Holley MC, Magistretti J, Russo G, Marcotti W & Masetto S (2014) Fine Tuning of CaV1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea. PLoS ONE, 9(11), e113750-e113750. Johnson SL, Wedemeyer C, Vetter DE, Adachi R, Holley MC, Elgoyhen AB & Marcotti W (2013) Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.. Open Biol, 3(11), 130163. Furness DN, Johnson SL, Manor U, Rüttiger L, Tocchetti A, Offenhauser N, Olt J, Goodyear RJ, Vijayakumar S, Dai Y, Hackney CM, Franz C, Di Fiore PP, Masetto S, Jones SM, Knipper M, Holley MC, Richardson GP, Kachar B & Marcotti W (2013) Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.. Proc Natl Acad Sci U S A, 110(34), 13898-13903.