陈德福 - 北京理工大学 - 医学技术学院

个人简介

2016年博士毕业于北京理工大学信息与电子学院，博士毕业后在美国Johns Hopkins University生物医学工程系进行3年的博士后研究工作，2020年7月作为特别副研究员加入医学技术学院，主要从事医学光学诊断和治疗技术及其在临床上的应用研究。作为项目负责人主持国自然青年、国自然重大科研仪器研制项目（合作单位主持）、北自然面上、国家研究中心开放课题等多个省部级以上项目，同时，作为骨干成员参与国家重点研发计划、国自然重大科研仪器研制项目、国自然重点项目、美国NIH的R01项目等多个项目的研究工作。目前已在Science Advances，Theranostics，Biomedical Optics Express，Photodiagnosis and Photodynamic Therapy等国际知名期刊上发表学术论文60余篇，申请/授权专利20项，多次受邀在国内外学术会议上作特邀报告，并在多个相关专业学会中担任委员。教育培训经历 2012.09-2016.06：北京理工大学 (博士) 2009.09-2012.07：福建师范大学 (硕士) 2005.09-2009.07：福建师范大学 (学士) 工作经历 2020.07-至今：北京理工大学医学技术学院/医工融合研究院 2016.10-2019.10：约翰.霍普金斯大学(博士后) 生物医学工程系

研究领域

新型医学光学成像技术开发及其在疾病诊断、疗效监测中的应用光动力疗法剂量监测技术及临床应用

近期论文

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In situ detection of human glioma based on tissue optical properties using diffuse reflectance spectroscopy Preventing Post-Traumatic Stress Disorder (PTSD) in rats with pulsed 810 nm laser transcranial phototherapy Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin A Generic and Effective System Dispersion Compensation Method: Development and Validation in Visible-Light OCT Ultrasonic irradiation enhanced the efficacy of antimicrobial photodynamic therapy against methicillin-resistant Staphylococcus aureus biofilm M-CSAFN: Multi-color Space Adaptive Fusion Network for Automated Port-wine Stains Segmentation Label-Free Metabolic Imaging In Vivo by Two-Photon Fluorescence Lifetime Endomicroscopy A water-dependent reversible photoacidity strategy for cancer treatment Immune response induced by hematoporphyrin derivatives mediated photodynamic therapy: Immunogenic cell death and elevated costimulatory molecules In vivo assessment of inflammatory bowel disease in rats with ultrahigh-resolution colonoscopic OCT Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo Peptide-based supramolecular photodynamic therapy systems: From rational molecular design to effective cancer treatment In vitro and in vivo evaluation of a chlorin-based photosensitizer KAE? for cancer treatment Enhanced antimicrobial activity through the combination of antimicrobial photodynamic therapy and low-frequency ultrasonic irradiation Label-Free Metabolic Imaging in vivo by Two-Photon Fluorescence Lifetime Endomicroscopy Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice Quantitative assessment of vascular features in port wine stains through optical coherence tomography angiography Imaging depth adaptive resolution enhancement for optical coherence tomography via deep neural network with external attention Label-free imaging of human brain tissue at subcellular resolution for potential rapid intra-operative assessment of glioma surgery Twist-free ultralight two-photon fiberscope enabling neuroimaging on freely rotating/walking mice Light Delivery Device Modelling for Homogenous Irradiation Distribution in Photodynamic Therapy of Non-spherical Hollow Organs Monitoring perfusion and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy Multicolor Fiber-optic Two-photon Endomicroscopy for Brain Imaging Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: analysis of results from China’s top 3 hospital, 2009–2019 In vivo assessment of vascular-targeted photodynamic therapy effects on tumor microvasculature using ultrahigh-resolution functional optical coherence tomography Throughput-Speed Product Augmentation for Scanning Fiber-Optic Two-Photon Endomicroscopy Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy Penetration-enhanced optical coherence tomography angiography with optical clearing agent for clinical evaluation of human skin Medical Application and Industrial Development Strategy of Laser Technology in China Ultra-sensitive optical coherence elastography using high-dynamic-range force loading scheme for cervical rigidity assessment Parallel deep neural networks for endoscopic OCT image segmentation A Biopsy-needle Compatible Varifocal Multiphoton Rigid Probe for Depth-resolved Optical Biopsy Modulating mitochondrial morphology enhances antitumor effect of 5-ALA-mediated photodynamic therapy both in vitro and in vivo Intraoperative monitoring of blood perfusion in port wine stains by laser Doppler imaging during vascular targeted photodynamic therapy: A preliminary study Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence Relationship between the blood perfusion values determined by laser speckle imaging and laser Doppler imaging in normal skin and port wine stains Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers Optical coherence tomography: A potential tool for prediction of treatment response for port wine stain after photodynamic therapy Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy Imaging singlet oxygen luminescence in blood vessels In vitro and in vivo antitumor activity of a novel hypocrellin B derivative for photodynamic therapy Monitoring blood volume fraction and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy with diffuse reflectance spectroscopy: Results of a preliminary case study Assessment of tissue perfusion changes in port wine stains after vascular targeted photodynamic therapy: A short-term follow-up study ERRATUM: "SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION" Singlet oxygen detection during photosensitization Feasibility Study on Quantitative Measurements of Singlet Oxygen Generation Using Singlet Oxygen Sensor Green Light-Emitting Diode-Based Illumination System for In Vitro Photodynamic Therapy Influence of pulse-height discrimination threshold for photon counting on the accuracy of singlet oxygen luminescence measurement Indirect imaging of singlet oxygen generation from a single cell Optimal discrimination threshold for the detection of singlet oxygen luminescence Kinetic analysis of singlet oxygen generation in a living cell using Singlet Oxygen Sensor Green Determination of singlet oxygen quantum yield of HiPorfin using Singlet Oxygen Sensor Green A new time-gated synchronization controller for the detection of singlet oxygen luminescence Detection system for singlet oxygen luminescence in photodynamic therapy

学术兼职

中国光学学会理事国家半导体照明工程研发及产业联盟紫外LED专业委员会副主任中国生物医学工程学会生物医学光子学分会青年委员中国光学学会生物医学光子学专业委员会青年委员中华医学会激光医学分会第九届委员会基础与计量安全防护学组成员中华医学会激光医学分会第九届委员会青年学组委员《中国激光》青年编委 SPIE/COS Photonics Asia程序委员会委员，IFWS&SSLCHINA技术程序委员会分会委员，BPC程序委员会委员，国际光学工程学会（SPIE）会员 Journal of Biophotonics，Journal of Biomedical Optics, Biomedical Optics Express, Photodiagnosis and Photodynamic Therapy, Quantitative Imaging in Medicine and Surgery, 中国激光、中国激光医学杂志等国内外学术期刊的审稿人