Furley, Andrew - University of Sheffield - Department of Biomedical Science

个人简介

2004-present: Senior Lecturer, Biomedical Science, University of Sheffield. Head of Research Training, Faculty of Science 1997-2004: Lecturer (Centre for Developmental & Biomedical Genetics), Biomedical Science, University of Sheffield 1992-1997: MRC Research Scientist, Division of Developmental Neurobiology, NIMR, Mill Hill, London 1990-1992: Howard Hughes Medical Institute Fellow, Center for Neurobiology & Behavior, Columbia University, New York (Advisor: T. Jessell) 1987-1990: Jane Coffin Childs Post-Doctoral Fellow, Dept of Biochemistry, Columbia University, New York (Advisors:F. Alt/T. Jessell) 1987: PhD Leukaemia Biology, Imperial Cancer Research/UCL, London (Supervisor: M. Greaves) 1982: B.Sc. (Hons) Molecular Biology, University of Edinburgh

研究领域

Our research is focussed on the role L1CAM-like cell adhesion molecules (L1-CNTNs) in neural development. L1-CNTNs affect neural function at all stages, including the earliest proliferation and differentiation of progenitor and stem cells (Bizzoca et al 2003; Ma et al 2008; Xenaki et al., 2011; Bizzoca et al., 2012), the guidance of axons (Cohen et al 1998; Law et al 2008; Dang et al., 2012), through to firing of action potentials (Poliak et al 2003) and functioning of synapses (Bliss et al 2000). As a result, these molecules are widely implicated in neurological disease and cancers. Our aim is to understand the cellular mechanisms through which L1-CNTNs affect this wide variety of processes.

近期论文

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Ha S, Stottmann RW, Furley AJ & Beier DR (2015) A forward genetic screen in mice identifies mutants with abnormal cortical patterning.. Cereb Cortex, 25(1), 167-179. Hadas Y, Nitzan N, Furley AJW, Kozlov SV & Klar A (2013) Distinct Cis Regulatory Elements Govern the Expression of TAG1 in Embryonic Sensory Ganglia and Spinal Cord. PLoS ONE, 8, e57960-e57960. View this article in White Rose Research Online Dang P, Smythe E & Furley AJ (2012) TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex.. J Neurosci, 32(30), 10370-10382.