Erdmann, Kai - University of Sheffield - Department of Biomedical Science

个人简介

2012-present: Senior Lecturer, University of Sheffield 2006-2012: Privatdozent, Group leader, Ruhr-University Bochum, Germany 2005-2006: Research Associate, Yale University School of Medicine, USA 2003-2005: Feodor Lynen Fellow (Alexander von Humboldt foundation), Yale University School of Medicine, USA 1998-2003: Junior group leader, Ruhr-University Bochum, Germany 1996-1998: Postdoctoral work, Ruhr-University Bochum, Germany 1993-1996: PhD, Ruhr-University Bochum, Germany 1987-1992: Diploma, Ruhr-University Bochum, Germany

研究领域

Membrane trafficking and signalling in polarised cells. Role of multi-PDZ domain proteins in cancer formation, metastasis and tumor invasion. Our group is interested in the regulation of membrane trafficking and its relation to human diseases. In particular we are interested in the molecular mechanism leading to Lowe syndrome, a X-linked disease characterized by congenital cataracts, mental retardation and kidney failure. Moreover, we analyze the molecular function of multi-PDZ domain proteins (PTPN13 and FRMPD2) in vesicular trafficking and signal transduction as well as their role in cancer development and progression.

近期论文

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Chen J, Balakrishnan-Renuka A, Hagemann N, Theiss C, Chankiewitz V, Chen J, Pu Q, Erdmann KS & Brand-Saberi B (2016) A novel interaction between ATOH8 and PPP3CB. Histochemistry and Cell Biology, 145(1), 5-16. Sharma S, Skowronek A & Erdmann KS (2015) The role of the Lowe syndrome protein OCRL in the endocytic pathway. Biological Chemistry, 396(12). Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2013) The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene, 32(39), 4602-4613. Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Has ler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S & Rosenstiel P (2012) RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition. Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21426-21431. Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2012) The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene. Hagemann N, Hou X, Goody RS, Itzen A & Erdmann KS (2012) Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome. Small GTPases, 3(2), 107-110.