Cunliffe, Vincent - University of Sheffield - Department of Biomedical Science

个人简介

2007 - present: Senior Lecturer 2002 - 2007: Lecturer 1997 - 2002: Lister Institute Research Fellow, Department of Biomedical Science, University of Sheffield 1994 - 1997: Group Leader in Molecular and Cell Biology, Therexsys Ltd, Keele, UK 1991 - 1994: Postdoctoral Fellow, Division of Developmental Biology, National Institute for Medical Research, London, UK. 1990: Postdoctoral Fellow, Postdoctoral Fellow, Department of Biochemistry, University of Washington, Seattle, USA. 1986 - 1990: PhD, Imperial Cancer Research Fund and University College, London. 1982 - 1986: BSc, University of Edinburgh.

研究领域

Our research is focused primarily on understanding the roles of epigenetic mechanisms in the development and function of the zebrafish Central Nervous System (CNS), and how gene-environment interactions impact on these processes. In addition, we are exploiting the practical advantages of the zebrafish as a model organism to investigate the functions of genes implicated in human neurological disorders and cancer.

近期论文

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Cunliffe VT The epigenetic impacts of social stress: how does social adversity become biologically embedded? Epigenomics. 2016 Dec;8(12):1653-1669. Epub 2016 Nov 21. Pickering J, Cunliffe VT, Van Eeden F, Borycki AG. Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix Biol. 2016 Nov 14. pii: S0945-053X(16)30224-4. doi: 10.1016/j.matbio.2016.11.004. [Epub ahead of print] Cunliffe VT (2016) Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures. Journal of Neuroscience Methods, 260, 91-95. Cunliffe VT (2016) Histone modifications in zebrafish development. Methods in Cell Biology, 135, 361-385. Cunliffe VT (2015) Experience-sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.