Bulgakova, Natalia - University of Sheffield - Department of Biomedical Science

个人简介

2015-present: Lecturer, Department of Biomedical Sciences, University of Sheffield, UK 2009-2015: Research associate, Gurdon Institute, University of Cambridge, UK 2007-2009: Research associate, Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany 2004-2007: PhD, Institut für Genetic, Heinrich-Heine Universität Düsseldorf, Germany

研究领域

The mechanism that attaches neighbouring cells in our body to each other is known as cell-cell adhesion. Recent work has demonstrated that cell-cell adhesion is also important for communication between the neighbouring cells to decide when to divide, migrate or die. Our lab is interested to understand how cell-cell adhesion contributes to normal development of a whole organism. We focus on E-cadherin, a transmembrane protein that provides cell-cell adhesion between the epithelial cells. Using a combination of genetic assays, biochemistry and quantitative imaging techniques in Drosophila model system we study how E-cadherin functions in various developmental processes, for example cell neighbour exchange and tissue growth, and how it is regulated during development. In future, we aim to apply this knowledge about normal function of E-cadherin to treatment of medical conditions arising from defects in E-cadherin function such as epithelia-derived tumours.

近期论文

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Bulgakova, N. A., & Brown, N. H. (2016). Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin-Bazooka complex. Journal of Cell Science, 129(3), 477-482. Panamarova, M., Cox, A., Wicher, K. B., Butler, R., Bulgakova, N., Jeon, S., Zernicka-Goetz, M. (2016). The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development, 143(8), 1271-1283.