Buck, Lauren - University of Sheffield - Department of Biomedical Science

个人简介

2016–Present: University Teacher, Level 2 Year Tutor and Deputy Level 1 Year Tutor. 2013-2016: University Teaching Associate, University of Sheffield. 2012-2013: University Teaching Assistant, University of Sheffield. 2008-2012: PhD student (BBSRC CASE) jointly supervised through the MRC Centre for Developmental and Biomedical Genetics (University of Sheffield), AstraZeneca Safety, Health and Environment (Brixham Environmental Laboratory, Devon) and Safety Assessment UK, AstraZeneca R&D (Alderley Park). 2005-2008: BSc (Hons) Biomedical Science, University of Sheffield.

研究领域

My research has been focussed on the use of the zebrafish as a model organism to identify the unwanted ototoxic effects of compounds at the early pre-clinical stages of drug development. Specifically, the research aimed to assess the comparative translational capability and validity of this model system by using a combination of established histological and novel functional assays. More detailed investigations into the underlying mechanisms of cisplatin-induced hair cell damage were performed to further validate the model, giving rise to a number of potential routes for further exploration. I currently hold a teaching (100%) position within the university but retain a fervent interest in ototoxicity research, particularly concerning the underlying mechanisms of cisplatin-induced hair cell damage and the prevention of cisplatin-induced ototoxicity. In 2014/15 I acted as Co-PI, supervising two PG Masters Students. The first project was part-funded by Action on Hearing Loss and involved collaboration with the Chemistry department; it focussed on testing newly synthesised photo-activated cisplatin-like compounds for their toxicity, and more specifically, toxicity to hair cells. The second project was tailored to a Taught Masters programme (MSc Molecular Medicine) and was entitled “The zebrafish as a screening tool to identify compounds with protective effects against cisplatin ototoxicity.” The screening project identified a number of novel protective compounds against cisplatin ototoxicity and further work will be required to validate and characterise these hit compounds and to understand their underlying mechanisms of action.

近期论文

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Riley A., Buck L and Buckley A. (2016). Tensions in the assessment of authentic project based learning. Abstract from 10th Annual Learning & Teaching Conference 2016, University of Sheffield. Buck L. and Riley A. Embedded Enterprise Case Study: BMS246 Introduction to Human Anatomy. Case Study. http://www.etctoolkit.org.uk/science-technology-engineering-and-maths/biomedical-science/ Buck L., Riley A. and Norkowska M. (2015) Embedding Enterprise into Core Teaching: Getting to the Heart of the Matter. Abstract from 9th Annual Learning & Teaching Conference 2015, University of Sheffield. Co-presented with an undergraduate student. Buck L., Sahal A., Rozenbroek-Nelson M. and Cooper G. Development of a cross-platform multimedia teaching resource to enhance the delivery of ‘Classical’ Physiology Practical Classes. Presented at the Annual Meeting of the Physiological Society, Physiology 2014, London