Ayscough, Kathryn - University of Sheffield - Department of Biomedical Science

个人简介

2016-present: Head of Department, Biomedical Science 2012-2016: Professor, Deputy Head of Biomedical Science 2008-2012: Professor and MRC Senior Research Fellow. Department of Molecular Biology and Biotechnology, University of Sheffield 2003 – 2008: MRC Senior Research Fellow. Department of Molecular Biology and Biotechnology, University of Sheffield 1999 – 2003: MRC Senior Research Fellow, Department of Biochemistry, University of Glasgow 1996 – 1999: Wellcome Trust Career Development Fellow, Department of Biochemistry, University of Dundee. 1993-1999: Wellcome International Travelling Fellow, University of California, Berkeley, USA. Supervisor David Drubin 1989 – 1993: PhD Imperial Cancer Research Fund (now CRUK) and University College London. Supervisor Graham Warren 1985-1989: BA MA(Oxon) Biochemistry, University of Oxford. 1st Class.

研究领域

The main research focus of my lab is to understand the mechanisms governing cell organization and architecture. We are currently addressing how one of the key elements of the cytoskeleton (actin) can initiate filaments formation and how these filaments can then be organized to allow inward bending of the plasma membrane. This invagination process is called endocytosis and allows cells to regulate their cell surface composition in response to environmental signals. We are also aiming to understand how the process of endocytosis is coupled to the invasion and survival properties of the human fungal pathogen Candida albicans.

近期论文

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Palmer, S. E., Smaczynska-de Rooij, I. I., Marklew, C. J., Allwood, E. G., Mishra, R., Johnson, S., Ayscough, K. R. (2015). A dynamin-actin interaction is required for vesicle scission during endocytosis in yeast. Current Biology, 25(7), 868-878. Smaczynska-de Rooij, I. I., Marklew, C. J., Allwood, E. G., Palmer, S. E., Booth, W. I., Mishra, R., Ayscough, K. R. (2016). Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1. Molecular and Cellular Biology, 36(5), 742-755.