Andrews, Peter - University of Sheffield - Department of Biomedical Science

个人简介

Department of Biomedical Science, University of Sheffield Arthur Jackson Professor of Biomedical Science: 1992 - present Chairman of Department 1995-2003 The Wistar Institute of Anatomy and Biology, Philadelphia: Associate Professor: 1991 - 1992 Assistant Professor: 1983 - 1990 Research Associate: 1980 - 1982 Research Investigator: 1978 - 1979 Sloan-Kettering Institute, New York: Research Fellow: 1976 - 1978 Institut Pasteur, Paris: Research Fellow: 1974 - 1975

研究领域

Human embryonic stem cells (HESCs) are derived from the inner cell mass of the early embryo; the cells are genetically normal and retain in vitro both the ability to self renew and also to differentiate into each of the cell types found in the adult body. Such a system offers an in vitro model of human embryogenesis. Thus, a powerful resource now exists for the investigation of human developmental biology, the testing of candidate drugs for toxicology and efficacy and ultimately, tissue engineering for regenerative medicine.

近期论文

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Isasi R, Andrews PW, Baltz JM, Bredenoord AL, Burton P, Chiu IM, Hull SC, Jung JW, Kurtz A, Lomax G, Ludwig T, McDonald M, Morris C, Ng HH, Rooke H, Sharma A, Stacey GN, Williams C, Zeng F, Knoppers BM. 2014 Identifiability and privacy in pluripotent stem cell research. Cell Stem Cell. 14: 427-430 Barbaric, I., Biga, V., Gokhale, P.J., Jones, M., Stavish, D., Glen,G., Coca, D., Andrews, P.W. 2014 Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation. Stem Cell Reports. 3: 142-155 Ben-David U, Gal Arad1, Maimon A, Mandefro B, Weissbein U, Golan-Lev T, Narwani K, Clark AT, Andrews PW, Benvenisty N, Biancotti JC. 2014 Trisomy 12 induces profound changes in the global gene expression signature, cellular proliferation and tumorigenicity of human pluripotent stem cells. Nature Communications 5: 4825 Sutiwisesak R, Kitiyanant N, Kotchabhakdi N, Felsenfeld G, Andrews PW, Wongtrakoongate P. 2014 Induced pluripotency enables differentiation of human nullipotent embryonal carcinoma cells N2102Ep. Biochim Biophys Acta. 1843: 2611-2619. Isasi R, Andrews PW, Baltz JM, Bredenoord AL, Burton P, Chiu IM, Hull SC, Jung JW, Kurtz A, Lomax G, Ludwig T, McDonald M, Morris C, Ng HH, Rooke H, Sharma A, Stacey GN, Williams C, Zeng F, Knoppers BM. 2014 Identifiability and privacy in pluripotent stem cell research. Cell Stem Cell. 14: 427-30. Na J, Baker D, Zhang J, Andrews PW, Barbaric I. 2014 Aneuploidy in pluripotent stem cells and implications for cancerous transformation. Protein Cell. 8: 569 -579