吕芳 - 北京理工大学

个人简介

1999.9～2002.7 黑龙江省中医药大学药学院医学硕士 2002.9～2005.7 北京大学药学院理学博士 2005.7～2007.6 北京大学化学与分子工程学院博士后 2007.7～至今北京理工大学生命学院教师 2013.8～2014.8 德国杜塞尔多夫大学访学学术成果研究内容主要以天然药物中化学成分分离为基础，通过高效、灵敏的HPLC-ESIMS/MSn分析方法，分析和应用药物中特征性成分的质谱裂解途径、裂解规律，从而获得未知的微量成分，甚至痕量成分的结构信息。作为项目负责人，承担国家自然基金青年基金项目(81503353)、高等学校博士学科点专项科研基金新教师课题基金(20091101120045)、海洋药物教育部重点实验室开放基金(KLMD(OUC)200807)、北京理工大学基础研究等，并参加了2项重大仪器专项研究，1项横向课题研究。作为申报人之一(8/9) 获得黑龙江省科技进步二等奖1项。申请发明专利4项(授权2项)

研究领域

天然药物中化学物质基础的研究及微量成分的定向分析药物开发与应用

近期论文

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Juan Song; Rongji Dai; Yulin Deng; Fang Lv(*). Rapid structure prediction by HPLC-ESI-MSn of twenty-five polyoxypregnane tetraglycosides from Dregea sinensis with NMR confirmation of eight structures. Phytochemistry 2018 (147) :147-157. XiuJie Liu; Yu Shi; ShaoHua Jia; YuLin Deng; Fang Lv(*); Rong-Ji Dai(*). Six new C-21 steroidal glycosides from Dregea sinensis Hemsl. Journal of Asian Natural Products Research 2017,19(8):754-753. Shaohua Jia; Juan Song; Rongji Dai; Yulin Deng; Fang Lv(*). Structural deduction of pregnane glycosides from Dregea sinensisHemsl by high-performance liquid chromatography and electrosprayionization-tandem mass spectrometry. International Journal of Mass Spectrometry 2017(415) 38-43. Fang Lv; Murtaza Hasan; Hao Dang; Shahbaz Gu Hassan; Weiwei Meng; Yulin Deng; Rongji Dai(*). Optimized Luteolin Loaded Solid Lipid Nanoparticle Under Stress Condition for Enhanced Bioavailability in Rat Plasma. Journal of Nanoscience and Nanotechnology 2016,16(9): 9443-9449. Shaohua Jia; Xiujie Liu; Rongji Dai; Weiwei Meng; Yulin Deng; Fang Lv(*). Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl. Phytochemistry Letters 2015, 11(1):209-214. Fang Lv; Georgios Daletos; Wenhan Lin; Peter Proksch(*). Two new cyclic depsipeptides from the endophytic fungus Fusarium sp. Natural Product Communications 2015,10(10):1667-1670. Hao Dang; Murtaza Hasan; Weiwei Meng; Haiwei Zhao; Javed Iqbal; Rongji Dai; YulinDeng; Fang Lv(*). Luteolin-loaded solid lipid nanoparticles synthesis, characterization, ＆ improvement of bioavailability, pharmacokinetics in vitro and vivo studies. Journal of Nanoparticle Research 2014,16(4):2347-2356. Shao-Hua Jia; Fang Lv(*); Rongji Dai; Weiwei Meng; Yan Chen; Yulin Deng. C-21 steroidal glycosides from Dregea sinensis Hemsl. Journal of Asian Natural Products Research 2014,16(8):836-840. Fang Lv; Shaohua Jia; Rongji Dai; Weiwei Meng;Yulin Deng. A New Steroid from Dregea sinensis Hemsl. Chemistry of Natural Compounds 2014,50(5):747-748.