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个人简介

解炳腾,男,1990年出生。2007年进入东北农业大学生物科学专业国家理科基地班(本硕博连读);2015年获理学博士学位,发育生物学专业;2015-2020年于北京大学第三医院从事博士后研究,助理研究员;2020年12月进入北京理工大学生命学院工作,任副研究员,硕士生导师。现已在Cell Research,Science Advances,Cancer Research等杂志发表SCI论文30余篇;获得国家自然科学基金、中国博士后基金、国家重点研发计划资助;北京大学优秀博士后,入选全国《2020年度博士后科学基金获得者选介》。

研究领域

生物分子原位与活体分析 肿瘤发生机制与治疗 生物传感与医学检测

近期论文

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Xie, B., Pu, Y., Yang, F., Chen, W., Yue, W., Ma, J., Zhang, N., Jiang, Y., Wu, J., Lin, Y., Liang, X., Wang, C., Zou, P., and Li, M. (2022) Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification. Cancer research DOI: 10.1158/0008-5472.CAN-22-0225 (首次利用APEX体系活细胞原位解析了PCM蛋白质组) Xie, B., and Luo, A. (2022) Nucleic Acid Sensing Pathways in DNA Repair Targeted Cancer Therapy. Frontiers in cell and developmental biology 10, 903781 (对DNA损伤修复和细胞固有免疫之间的关系进行了综述) Wu, Y., Zhu, P., Jiang, Y., Zhang, X., Wang, Z., Xie, B., Song, T., Zhang, F., Luo, A., Li, S., Xiong, X., and Han, J. (2022) Topological insulator Bi(2)Se(3) based electrochemical aptasensors for the application of sensitive detection of interferon-γ. Journal of materials chemistry. B DOI: 10.1039/d2tb01760a (基于量子功能材料针对干扰素γ构建了新型电化学传感器) Yue, W., Ma, J., Xiao, Y., Wang, P., Gu, X., Xie, B., and Li, M. (2022) The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. Frontiers in cell and developmental biology 10, 889656 (解析了BRCA1缺陷卵巢癌细胞的抗凋亡机制) Liang, A., Tang, S., Liu, M., Yi, Y., Xie, B., Hou, H., and Luo, A. (2022) A molecularly imprinted electrochemical sensor with tunable electrosynthesized Cu-MOFs modification for ultrasensitive detection of human IgG. Bioelectrochemistry (Amsterdam, Netherlands) 146, 108154 (针对IgG蛋白构建了新型分子印迹电化学传感器) Xie, B. (#), Liang, X. (#), Yue, W. (#), Ma, J., Li, X., Zhang, N., Wang, P., Liu, C., Shi, X., and Qiao, J. J. F. R. (2021) Targeting cytokinesis bridge proteins to kill high-CIN type tumors. Fundamental Research 1, 752-766 (首次利用APEX体系活细胞原位解析了细胞间桥蛋白质组) Zhang, N., Sun, A. D., Sun, S. M., Yang, R., Shi, Y. Y., Wang, Q. L., Li, X. Y., Ma, J. H., Yue, W., Xie, B. T. (*), Qiao, J., and Li, M. (*) (2021) Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile. Acta pharmacologica Sinica 42, 2144-2154 (首次利用APEX体系活细胞原位解析了卵母细胞线粒体蛋白质组) Du, H., Xia, H., Liu, T., Li, Y., Liu, J., Xie, B., Chen, J., Liu, T., Cao, L., Liu, S., Li, S., Wang, P., Wang, D., Zhang, Z., Li, Y., Guo, X., Wu, A., Li, M., and You, F. (2021) Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer. iScience 24, 102169 (发现ELF4的缺失使得宿主易患结直肠癌) Lin, Y., Xie, B., Li, X., Li, R., Ma, C., Zhu, J., and Qiao, J. (2021) Supplementation of the In Vitro Maturation Culture Medium of Mouse Oocytes with Growth Hormone Improves Pregnancy Outcomes. Reproductive sciences (Thousand Oaks, Calif.) 28, 2540-2549 (发现小鼠卵母细胞体外成熟培养基中添加生长激素可改善妊娠结局) Li, W., Gu, X., Liu, C., Shi, Y., Wang, P., Zhang, N., Wu, R., Leng, L., Xie, B., Song, C., and Li, M. (2021) A synergetic effect of BARD1 mutations on tumorigenesis. Nature communications 12, 1243 (首次发现了BARD1突变对肿瘤发生的协同作用) Ling, X. (#), Xie, B. (#), Gao, X. (#), Chang, L., Zheng, W., Chen H., Huang, Y., Tan, L., Li, M. (*), Liu, T. (*) (2020). Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates, Science Advances, 08 APR 2020 : EAAZ0051 (基于密码子扩展技术建立了一种提高基因编辑效率的方法) Song, J., Zhuang, Y., Zhu, C., Meng, H., Lu, B., Xie, B., Peng, J., Li, M., and Yi, C. (2020) Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nature chemical biology 16, 160-169 (发现了人PUS10蛋白的新功能) Dong, Z. Z., Jiao, Y. L., Xie, B. T., Hao, Y. C., Wang, P., Liu, Y. Y., Shi, J. F., Chitrakar, C., Black, S., Wang, Y. C., Lee, L. J., Li, M., Fan, Y. B., and Chang, L. Q. (2020) On-chip multiplexed single-cell patterning and controllable intracellular delivery. Microsystems & Nanoengineering 6, 1-11 (建立了一种向单细胞中递送物质的新方法) Miao, Y. (#), Wang, P. (#), Xie, B. (#), Yang, M., Li, S., Cui, Z., Fan, Y., Li, M. (*), and Xiong, B. (*) (2019) BRCA2 deficiency is a potential driver for human primary ovarian insufficiency. Cell death & disease 10, 474 (发现了一条造成人卵巢早衰的新机制) Shi, Y. Y., Zhou, S. L., Wang, P., Guo, Y. L., Xie, B. T. (*), and Ding, S. G(*). (2019) Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients. OncoTargets and therapy 12, 5589-5599 (发现了ME1在胃癌发生及预后的作用) Jin, Y., Yang, M., Gao, C., Yue, W., Liang, X., Xie, B., Zhu, X., Fan, S., Li, R., and Li, M. (2019) Fbxo30 regulates chromosome segregation of oocyte meiosis. Cellular and molecular life sciences 76, 2217-2229 (发现了Fbxo30在小鼠卵母细胞成熟中的作用) Xie, B. (#), Zhang, L. (#), Zhao, H., Bai, Q., Fan, Y., Zhu, X., Yu, Y., Li, R., Liang, X., Sun, Q. Y., Li, M. (*), and Qiao, J. (*) (2018) Poly(ADP-ribose) mediates asymmetric division of mouse oocyte. Cell Research. 28, 462-475 (发现了蛋白翻译后修饰PAR的新功能;被人民网等多家媒体报道) Xie, B. (#), Zhang, H. (#), Wei, R., Li, Q., Weng, X., Kong, Q., and Liu, Z. (*) (2016) Histone H3 lysine 27 trimethylation acts as an epigenetic barrier in porcine nuclear reprogramming. Reproduction 151, 9-16 (首次发现H3K7me3对细胞重编程的抑制作用;为该杂志当年引用前十) Kong, Q. R. (#), Xie, B. T. (#), Zhang, H., Li, J. Y., Huang, T. Q., Wei, R. Y., and Liu, Z. H. (*) (2016) RE1-silencing Transcription Factor (REST) Is Required for Nuclear Reprogramming by Inhibiting Transforming Growth Factor beta Signaling Pathway. J. Biol. Chem. 291, 27334-27342 (解析了一条新的猪核移植重编程机制) Wang, J., Li, X., Wang, L., Li, J., Zhao, Y., Bou, G., Li, Y., Jiao, G., Shen, X., Wei, R., Liu, S., Xie, B., Lei, L., Li, W., Zhou, Q., and Liu, Z. (2016) A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO reports 17, 1452-1470 (新鉴定了一种对小鼠胚胎发育重要的lncRNA) Huan, Y. J., Wu, Z. F., Zhang, J. G., Zhu, J., Xie, B. T., Wang, J. Y., Li, J. Y., Xue, B. H., Kong, Q. R., and Liu, Z. H. (2016) Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos. The Journal of reproduction and development 62, 71-77 (建立了一种新的提高猪克隆效率的方法) Huan, Y., Xie, B., Liu, S., Kong, Q., and Liu, Z. (2015) A novel role for DNA methyltransferase 1 in regulating oocyte cytoplasmic maturation in pigs. PloS one 10, e0127512 (发现了猪卵母细胞中DNMT1对早期胚胎发育的作用) Huan, Y., Hu, K., Xie, B., Shi, Y., Wang, F., Zhou, Y., Liu, S., Huang, B., Zhu, J., Liu, Z., He, Y., Li, J., Kong, Q., and Liu, Z. (2015) Ovulation Statuses of Surrogate Gilts Are Associated with the Efficiency of Excellent Pig Cloning. PloS one 10, e0142549 (发现胚胎移植受体状态对猪克隆效率的影响) Li, J., Huan, Y., Xie, B., Wang, J., Zhao, Y., Jiao, M., Huang, T., Kong, Q., and Liu, Z. (2014) Identification and characterization of an oocyte factor required for sperm decondensation in pig. Reproduction 148, 367-375 (发现一个IVF过程中猪精子解凝集相关的重要蛋白) Kong, Q., Ji, G., Xie, B., Li, J., Mao, J., Wang, J., Liu, S., Liu, L., and Liu, Z. (2014) Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. Stem cell reviews and reports 10, 399-407 (发现TSA可以促进克隆猪的端粒延长) Kong, Q., Hai, T., Ma, J., Huang, T., Jiang, D., Xie, B., Wu, M., Wang, J., Song, Y., Wang, Y., He, Y., Sun, J., Hu, K., Guo, R., Wang, L., Zhou, Q., Mu, Y., and Liu, Z. (2014) Rosa26 locus supports tissue-specific promoter driving transgene expression specifically in pig. PloS one 9, e107945 (确认了Rosa26位点在猪中的有效性) Huan, Y. J., Zhu, J., Wang, H. M., Wu, Z. F., Zhang, J. G., Xie, B. T., Li, J. Y., Kong, Q. R., Liu, Z. H., and He, H. B. (2014) Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. The Journal of reproduction and development 60, 377-382 (解析了提高猪克隆效率的机制) Gu, Q., Hao, J., Hai, T., Wang, J., Jia, Y., Kong, Q., Wang, J., Feng, C., Xue, B., Xie, B., Liu, S., Li, J., He, Y., Sun, J., Liu, L., Wang, L., Liu, Z., and Zhou, Q. (2014) Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein & cell 5, 338-342 (建立了新的猪IPS细胞的诱导培养方法) Kong, Q. (#), Xie, B. (#), Li, J. (#), Huan, Y., Huang, T., Wei, R., Lv, J., Liu, S., and Liu, Z. (*) (2014) Identification and characterization of an oocyte factor required for porcine nuclear reprogramming. J. Biol. Chem. 289, 6960-6968 (鉴定了猪卵母细胞的蛋白质组) Xie, B. (#), Wang, J. (#), Liu, S., Wang, J., Xue, B., Li, J., Wei, R., Zhao, Y., and Liu, Z. (*) (2014) Positive correlation between the efficiency of induced pluripotent stem cells and the development rate of nuclear transfer embryos when the same porcine embryonic fibroblast lines are used as donor cells. Cellular reprogramming 16, 206-214 (发现了不同重编程方法效率之间的相关性) Huan, Y. J., Zhu, J., Xie, B. T., Wang, J. Y., Liu, S. C., Zhou, Y., Kong, Q. R., He, H. B., and Liu, Z. H. (2013) Treating cloned embryos, but not donor cells, with 5-aza-2'-deoxycytidine enhances the developmental competence of porcine cloned embryos. The Journal of reproduction and development 59, 442-449 (建立了一种新的提高猪克隆效率的方法) He, W., Kong, Q., Shi, Y., Xie, B., Jiao, M., Huang, T., Guo, S., Hu, K., and Liu, Z. (2013) Generation and developmental characteristics of porcine tetraploid embryos and tetraploid/diploid chimeric embryos. Genomics, proteomics & bioinformatics 11, 327-333 (优化了猪四倍体胚胎的构建方法) Cong, Y., Ma, J., Sun, R., Wang, J., Xue, B., Wang, J., Xie, B., Wang, J., Hu, K., and Liu, Z. (2013) Derivation of putative porcine embryonic germ cells and analysis of their multi-lineage differentiation potential. Journal of genetics and genomics 40, 453-464 (建立了猪EG细胞系的分离培养方法)

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