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个人简介

本人从事纳米与生物交叉研究,围绕肿瘤精准高效诊疗这一国际前沿重要科学问题和难题,在肿瘤生物治疗新技术新方法方面开展了系列工作。目前,在Angew. Chem. Int. Ed., ACS Nano, Sci. China Chem.等高水平刊物发表SCI收录论文15篇,被引450余次。2021年获批国家自然科学基金青年项目1项,2020年获批第68批中国博士后科学基金面上项目资助1项。曾荣获北京市优秀毕业生、北京理工大学优博、北京理工大学优秀团干部等荣誉。 教育经历 2015.09-2020.03 工学博士,化学工程与技术,北京理工大学,导师:谢海燕(杰青) 2013.01-2015.01 联合培养硕士,中国科学院长春应用化学研究所,导师:唐涛(杰青) 2012.09-2015.03 工学硕士,化学工程与技术,哈尔滨工程大学,导师:王军、刘文彬 2008.09-2012.06 工学学士,制药工程,南昌大学 工作经历 2022.01-至今 副教授/特别研究员,生命学院,北京理工大学 2020.04-2022.01 博士后,材料学院,北京理工大学,合作导师:钟海政 获奖及荣誉 北京市优秀毕业生,2020 北京理工大学优博,2020 北京理工大学优秀团干部,2016 主持或主要参与基金项目 国家自然科学基金青年项目,精准靶向免疫协同的高效光动力治疗系统,30万元,在研,主持 中国博士后基金第68批面上项目,高效可视化NK细胞治疗系统的构建及应用,8万元,已结题,主持 国家自然科学基金面上项目,协同响应激活的高特异性肿瘤诊疗系统,66万元,在研,参与

研究领域

为适应《“健康中国2030”规划纲要》提出的“发展新型疫苗、生物治疗”、“早诊早治”、“加强医药技术创新”的国家需求,课题组将发挥生物学、材料学、免疫学、医学、化学等多学科交叉融合研究的特色优势,沿着“高效肿瘤预防及诊疗方法的开发”这一方向深入研究,为新型生物材料的设计、开发及应用奠定基础。具体的研究方向如下: (1)疾病精准诊断:基于高灵敏成像能力的新型纳米材料的合成及工程化改造,实现对不同疾病(肿瘤、炎症、心脑血管疾病等)的早期诊断 (2)肿瘤预防:基于高效的新型肿瘤疫苗的开发,实现对不同类型肿瘤的高效预防 (3)肿瘤高效治疗:基于新型生物疗法(细胞、抗体、基因疗法等)与化疗、光/化动力治疗、光/磁热治疗等的协同组合治疗策略,构建可满足不同治疗需求的肿瘤高效治疗平台 (4)疾病的个性化治疗:基于类器官或器官芯片研究免疫机制,探索疾病的个性化免疫治疗

近期论文

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Weidong Nie, Wenlin Fan, Anqi Jiang, Guanghao Wu, Houli Liu, Li-Li Huang, Hai-Yan Xie*. Natural killer cell-derived extracellular vesicle significantly enhanced adoptive T cell therapy against solid tumors via versatilely immunomodulatory coordination. Sci. China Chem. 2021, 64, 1999. (IF=9.445, Q1) Weidong Nie, Guanghao Wu, Jinfeng Zhang, Li-Li Huang, Jingjing Ding, Anqi Jiang, Yahui Zhang, Yanhong Liu, Kanyi Pu*, Hai-Yan Xie*. Responsive Exosome Nano-Bioconjugates for Synergistic Cancer Therapy. Angew. Chem. Int. Ed. 2020, 59, 2018. (IF: 15.336; Q1) Weidong Nie, Wei Wei, Liping Zuo, Chengliang Lv, Fan Zhang, Gui-Hong Lu, Feng Li, Guanghao Wu, Li?Li Huang, Xiaobo Xi, Hai-Yan Xie*. Magnetic Nano-Clusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T Cell Therapy for Solid Tumors. ACS Nano 2019, 13, 1469. (IF=15.881, Q1) Weidong Nie, Jie Liu*, Wenbin Liu*, Jun Wang, Tao Tang*. Decomposition of waste carbon fiber reinforced epoxy resin composites in molten potassium hydroxide. Polym. Degrad. Stabil. 2015, 111, 247. (IF=5.030, Q1) Weidong Nie, Guanghao Wu, Haizheng Zhong and Hai-Yan Xie*. Membrane vesicles nanotheranostic systems: sources, engineering methods, and challenges. Biomed. Mater. 2021, 16, 022009. (IF: 3.715; Q2) Li-Li Huang, Weidong Nie, Jinfeng Zhang, and Hai-Yan Xie*. Cell-Membrane-Based Biomimetic Systems with Bioorthogonal Functionalities. Acc. Chem. Res. 2020, 53, 276. (IF: 22.384; Q1) Liping Zuo, Weidong Nie, Songmao Yu, Wanru Zhuang, Guanghao Wu, Houli Liu, Lili Huang, Danshu Shi, Xin Sui, Yongheng Li*, Hai-Yan Xie*. Smart Tumor-Cell-Derived Microparticles Provide On-Demand Photosensitizer Synthesis and Hypoxia Relief for Photodynamic Therapy. Angew. Chem. Int. Ed. 2021, 60, 25365. (IF: 15.336; Q1) Feng Li, Weidong Nie, Fan Zhang, Guihong Lu, Chengliang Lv, Yanlin Lv, Weier Bao, Lijun Zhang, Shuang Wang, Xiaoyong Gao, Wei Wei*, and Hai-Yan Xie*. Engineering Magnetosome for High-Performance Cancer Vaccination. ACS Central Sci. 2019, 5, 796. (IF=14.553, Q1) Jinfeng Zhang, Weidong Nie, Rui Chen, Jipsa Chelora, Yingpeng Wan, Xiao Cui, Xiaohong Zhang, Wenjun Zhang, Xianfeng Chen, Hai-Yan Xie, Chun-Sing Lee*. Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy, Nano Lett. 2019, 19, 658. (IF=11.189, Q1) Jingjing Ding, Guihong Lu, Weidong Nie, Li-Li Huang, Yahui Zhang, Wenlin Fan, Guanghao Wu, Houli Liu, Hai-Yan Xie*. Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy. Adv. Mater. 2021, 33, 2005562. (IF: 30.849; Q1) Houli Liu, Yao Lei, Weidong Nie, Helin Zhao, Yuzhu Wu, Liping Zuo, Guanghao Wu, Ruili Yang*, Hai-Yan Xie*. Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy. Nano Res. 2022. (IF: 8.897; Q1) Fan Zhang, Lili Wu, Weidong Nie, Lili Huang, Jinfeng Zhang, Feng Li, Hai-Yan Xie*. Biomimetic Microfluidic System for Fast and Specific Detection of Circulating Tumor Cells. Anal. Chem. 2019, 91, 15726. (IF: 6.986; Q1) Fan Zhang, Feng Li, Guihong Lu, Weidong Nie, Lijun Zhang, Yanlin Lv, Weier Bao, Xiaoyong Gao, Wei Wei*, Kanyi Pu, Hai-Yan Xie*. Engineering Magnetosomes for Ferroptosis/ Immunomodulation Synergism in Cancer. ACS Nano 2019, 13, 5662. (IF=15.881, Q1) Guanghao Wu, Wei Wei, Jinfeng Zhang, Weidong Nie, Lan Yuan, Yuanyu Huang, Liping Zuo, Lili Huang, Xiaobo Xi and Hai-Yan Xie*, A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis. Biomaterials 2020, 250, 119963 (IF=12.479, Q1) Lipeng Zhang, Jie Liu*, Weidong Nie, Kai Wang, Yanhui Wang, Xiuyun Yang*, Tao Tang*. Degradation of anhydride-cured epoxy resin using simultaneously recyclable solvent and organic base catalyst. J. Mater. Cycles Waste 2018, 20, 568. (IF=2.863, Q3)

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