全贞贞 - 北京理工大学

个人简介

2018-01--至今北京理工大学助理教授 2015.03-2018.01 北京理工大学博士后 2008.10-2014.07 英国剑桥大学生物博士学位课题经费及来源 2018/01-2020/12，Rab21对γ-分泌酶的调控机制以及其作为治疗阿尔茨海默病潜在靶点的研究，国家自然科学基金青年项目，81701260，主持 2019/01-2021/12，基于微纳生物组装的仿生神经接口构建，国家重点研发计划国际间合作专项项目，2017YFE0117000，子课题负责人 2019/01-2022/12，基于靶向蛋白质组学筛选技术的阿尔茨海默病早期诊断生物标志物研究，国家自然科学基金面上项目，81870844，参与 2018/08-2021/12，血管性认知功能障碍的发病机制及干预研究，国家重点研发计划重大慢性非传染性疾病防空研究重点专项项目，2018YFC1312300，参与 2019/01-2022/12，促神经再生的氮杂类黄酮的设计与合成及其增殖分化机制，国家自然科学基金面上项目，21878022，参与 2018/01-2021/12，仿生机器鼠与模式鼠自然交互及行为控制，国家自然科学基金面上项目，61773058，参与 2017/01-2020/12，锌指蛋白ZNF335调控BACE活性及在阿尔茨海默症发生中的研究，国家自然科学基金面上项目，81671268，参与 2016/11-2017/04，Rab21作为治疗阿尔茨海默病潜在靶点的研究，中国博士后科学基金，2016M600931，主持 2015/04-2015/12,ZNF335在阿尔茨海默症中关键致病因子BACE1的调控探究, 北京理工大学科技创新计划重大项目培育专项计划，3160012231501，主持

研究领域

阿尔兹海默症(AD)发病机制的研究以及相关药物的开发，学习记忆相关的脑区功能研究等

近期论文

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代表性论著 Qinghu Yang#; Da Song#; Zhen Xie; Guiqiong He; Juan Zhao; Zhe Wang; Zhifang Dong; Heao Zhang; Liang Yang;Ming Jiang;Yili Wu;Qing Shi; Junjie Li;Jun Yang; Zhantao Bai; Zhenzhen Quan*; Hong Qing *; Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. Progress in Neurobiology. 2021 Dec 22:102209. doi: 10.1016/j.pneurobio.2021.102209. (IF=11.89) Yan Yan; Ailikemu Aierken; Chunjian Wang; Da Song; Junjun Ni; Zhe Wang; Zhenzhen Quan*; Hong Qing*; A potential biomarker of preclinical Alzheimer's disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments. Neuroscience and Biobehavioral Reveview. 2021 Nov 19:S0149-7634(21)00502-9. \ Da Song#; Deheng Wang#; Qinghu Yang#; Tianyi Yan#; Zhe Wang; Yan Yan; Juan Zhao; Zhen Xie; Yuchen Liu; Zunji Ke; Tala Jamil Qazi; Yanhui Li; YIli Wu; Qing Shi; Yiran Lang; Heao Zhang; Tao Huang; Chunjian Wang; Zhenzhen Quan*; Hong Qing*; The lateralization of left hippocampal CA3 during the retrieval of spatial working memory, Nature Communications. 2020, 11(1)(2901). (IF=12.1) Zhen Xie; Qinghu Yang; Da Song; Zhenzhen Quan*; Hong Qing*; Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases, Glia. 2020, 68(2):215-226. Heao Zhang; Chunxu Yuan; Kefu Liu; Qifan Yang; Juan Zhao; Hui Li; Qinghu Yang; Da Song; Zhenzhen Quan*; Hong Qing*; Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy. Neural Regenerative Research. 2022 Jan;17(1):152-162. Liang Yang; Yong Wang; Nuomin Li; Bing Xu; Juanhui Duan; Chunxu Yuan; Qinfen Yuan; Qifan Yang; Hong Qing; Zhi Dai*; Zhenzhen Quan*; The Anti-Depression-Like Effects of Zhengtian Capsule via Induction of Neurogenesis and the Neurotrophic Signaling Pathway, Frontiers in Pharmacology. 2020, 11(1338). Da Song; Qinghu Yang; Yiran Lang; Zhaosen Wen; Zhen Xie; Da Zheng; Tianyi Yan; Yujun Deng; Hiroshi Nakanishi; Zhenzhen Quan*; Hong Qing*; Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodicshort-term memory, especially working memory, but not long-term memory, Neurobiology of Learning and Memory. 2018, 155: 435-445. Zhenzhen Quan; Da Zheng; Hong Qing*; Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases. Frontiers in Cellular Neuroscience. 2017 Jun 30;11:175. doi: 10.3389/fncel.2017.00175. Xianghan Wang; Jianxin Du; Demei Wang; Fan Zeng; Yukui Wei; Fuli Wang; Chengcheng Feng; Nuomin Li; Rongji Dai; Yulin Deng; Zhenzhen Quan*; Hong Qing*; Effects of simulated microgravity on human brain nervous tissue. Neuroscience Letters. 2016 Aug 3;627:199-204. doi: 10.1016/j.neulet.2016.06.004. Zhenzhen Quan; Lu Cao; Yingzhi Tang; Yanchun Yan, Stephen G Oliver; Nianshu Zhang*; The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan. PLoS Genetics. 2015 Jun 23;11(6):e1005282. doi: 10.1371/journal.pgen.1005282. Quan, Zhenzhen(#)，Zhou, Mei，Chen, Wei，Chen, Tianbao，Walker, Brian，Shaw, Chris，Novel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors. Peptides. 2008.8.01,29 (8):1456~1460. 已发表的其余论著 Duru, LN(#)，Quan, Z，Qazi, TJ，Qing, H(*). Stem cells technology: a powerful tool behind new brain treatments. Drug Delivery Translational Research. 2018 Oct; 8(5):1564-1591. Lu, J(#)，Xu, Y，Quan, Z，Chen, Z，Sun, Z，Qing, H(*)，Dysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease. Neuroscience. 2017 Sep 28;365:70-82. Sun, Zhenzhen，Xie, Yujie，Chen, Yintong，Yang, Qinghu，Quan Zhenzhen，Dai,Rongji，Qing, Hong. Rab21, a novel PS1 interactor, regulates gamma-secretase activity via PS1 subcellular distribution. Molecular Neurobiology. 2017. 5.27., doi:10.1007/s12035-017-0606-3ol. Qazi, Talal Jamil(#)，Quan, Zhenzhen，Mir, Asif，Qing, Hong(*)，Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation. Molecular Neurobiology. 2017.1.14. doi: 10.1007/s12035-016-0357-6. Cao, Lu(#)，Tang, Yingzhi，Quan, Zhenzhen，Zhang, Zhe，Oliver, Stephen G，Zhang, Nianshu, Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases. PLoS Genetics. 2016.12.01,12(12)：e1006458~e1006458. Xu, Yan(#)，Zhang, Yanyan，Quan, Zhenzhen，Wong, Winnie，Guo, Jianping，Zhang, Rongkai，Yang, Qinghu，Dai, Rongji，McGeer, Patrick L，Qing, Hong(*)，Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson's Disease. Neurochem Res. 2016.10.01，41(10)：2788~2796. Zhang, Nianshu(#)，Quan, Zhenzhen，Rash, Bharat，Oliver, Stephen G，Synergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth. Open Biology.2013.5.22,3 (5)：120137~120137.