个人简介
教育背景
2012.10-2016.3 九州大学，齿学研究院，老年医学与药理，博士
2010.9-2012.7 北京理工大学，生命学院，神经生物学，硕士
2006.9-2010.7 青岛大学，医学院, 生物技术，学士
工作经历
2019.11-至今，北京理工大学，生命学院， 特别研究员
2016.3-2019.10 九州大学，齿学研究院，老年医学与药理，助理教授
主持及参与项目
国家自然科学基金委员会，面上项目，32070954，小胶质细胞及神经元的组织蛋白酶B参与阿尔兹海默病的发病机制研究，2021-1至2024-12， 58万元，在研，主持
北京市科学技术委员会，面上项目，7212066，组织蛋白酶B调节神经元功能在阿尔兹海默症中的作用及机制，2021-1至2023-12, 20万元，在研，主持
北京理工大学，科技创新计划，2020CX04166，组织蛋白酶E调节小胶质细胞功能在阿尔兹海默症中的作用及机制，2020-1至2022-12, 60万元，在研，主持
日本学术振兴会，青年学者科研基金，JP17K17093，The role of cathepsins in Aβ degradation in Alzheimer’s-like disease, 2017-4至2019-3, 416万日元（27.4万元），已结题，主持
日本学术振兴会，挑战萌芽基金，JP18K19650，The effects of gingipain on the pathogenesis of Alzheimer’s disease，2018-6至2021-3，637万日元（39万元），已结题，参与
国家自然科学基金委员会，面上项目，81171206, 早衰因子对β-分泌酶(BACE1)的调控与阿尔兹海默症致病机理的研究, 2012-01至2015-12，60万元，已结题，参与
近期论文
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Ni, J.* & Wu, Z.* (2021) Inflammation Spreading: Negative Spiral Linking Systemic Inflammatory Disorders and Alzheimer's Disease, Front Cell Neurosci. 15, 638686.
Zeng, F., Liu, Y., Huang, W., Qing, H., Kadowaki, T., Kashiwazaki, H., Ni, J.*& Wu, Z.* (2020) Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid beta accumulation after Porphyromonas gingivalis infection, J Neurochem.
Meng, J., Liu, Y., Xie, Z., Qing, H.,*Lei, P.,*&Ni, J.* (2020) Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins, Neurobiol Aging. 96, 255-266.
Jiang, M., Meng, J., Zeng, F., Qing, H., Hook, G., Hook, V., Wu, Z. * & Ni, J.* (2020) Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling, J Neurochem. 155, 300-312.
Gu, Y., Wu, Z.*, Zeng, F., Jiang, M., Teeling, J. L., Ni, J.* & Takahashi, I.* (2020) Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer's Disease-Like Pathologies in Middle-Aged Mice, J Alzheimers Dis. 78, 61-74.
Nie, R., Wu, Z*., Ni, J., * Zeng, F., Yu, W., Zhang, Y., Kadowaki, T., Kashiwazaki, H., Teeling, J. L. & Zhou, Y*. (2019) Porphyromonas gingivalis Infection Induces Amyloid-beta Accumulation in Monocytes/Macrophages, J Alzheimers Dis. 72, 479-494.
Ni, J., Wu, Z., Stoka, V., Meng, J., Hayashi, Y., Peters, C., Qing, H., Turk, V. & Nakanishi, H. (2019) Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice, Aging Cell. 18, e12856.
Ni, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H. & Nakanishi, H. (2019) An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain, J Neuroinflammation. 16, 173.
Wu, Z#., Ni, J#., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H. (2017) Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice, Brain Behav Immun. 65, 350-361.
Ni, J#., Wu, Z#., Meng, J., Zhu, A., Zhong, X., Wu, S. & Nakanishi, H. (2017) The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells, Oxid Med Cell Longev. 2017, 7984327.
Dekita, M#., Wu, Z#., Ni, J#., Zhang, X., Liu, Y., Yan, X., Nakanishi, H. & Takahashi, I. (2017) Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis, Front Pharmacol. 8, 470.
Ni, J., Wu, Z., Peterts, C., Yamamoto, K., Qing, H. & Nakanishi, H. (2015) The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage, J Neurosci. 35, 12488-501.
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