高昂 - 北京理工大学

个人简介

2019至今北京理工大学，生命学院（教授） 2013-2019 纽约大学，医学院（博士后） 2008-2013 中国科学院生物物理研究所, 生物大分子国家重点实验室（博士） 2005-2008 山东大学, 微生物国家重点实验室（硕士） 2001-2005 山东大学，生命科学学院（学士）代表性奖励 2019 国家级青年人才 2013 北京市优秀毕业生 2013 中国科学院优秀毕业生

研究领域

本课题组目前的主要研究方向为细菌中RNA介导的基因表达调控，特别是致病性基因的表达调控机制。综合运用生物化学、结构生物学和微生物学等多种手段，阐释RNA水平上的基因表达调控的分子机制，为相关疾病治疗提供理论依据和新的思路

近期论文

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Gao A#, Vasilyev N#, Kaushik A, Duan W, Serganov A* (2020). Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res. gkaa024, doi: 10.1093/nar/gkaa024 Zhu Y#, Gao A#, Zhan Q, Wang Y, Feng H, Liu S, Gao G, Serganov A*, Gao P* (2019). Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Mol Cell. 74(2):296-309. Gao A, Vasilyev N, Luciano DJ, Levenson-Palmer R, Richards J, Marsiglia WM, Traaseth NJ, Belasco JG, Serganov A* (2018). Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF. Nucleic Acids Res. 46(13):6841-6856. Wang Y#, Shi M, Feng H, Zhu Y, Liu S, Gao A*, Gao P* (2018). Structural insights into Non-canonical ubiquitination catalyzed by SidE. Cell. 173(5):1231-1243. Peselis A, Gao A, Serganov A (2016). Preparation and crystallization of riboswitches. Methods Mol Biol. 1320: 21-36. Peselis A, Gao A, Serganov A (2015). Cooperativity, allostery and synergism in ligand binding to riboswitches. Biochimie. 117: 100-9. Gao A, Sergaov A (2014). Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nature Chem Biol. 10(9): 787-92. Gao A, Mei GY, Liu S, Wang P, Tang Q, Liu YP, Wen H, An XM, Zhang LQ, Yan XX, Liang DC (2013). High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism of N-acyl homoserine lactonase. Acta Crystallographica Section D. 69(Pt 1): 82-91. Tang Q, Gao P, Liu YP, Liu S, Gao A, An XM, Yan XX, and Liang DC (2012). RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA. Nucleic Acids Res. 40(21): 11115-25. Song G, Li Y, Cheng C, Zhao Y, Gao A, Zhang R, Joachimiak A, Shaw N, Liu ZJ (2009). Structural insight into acute intermittent porphyria. FASEB J. 23(2): 396-404.