董磊 - 北京理工大学

个人简介

教育背景 2008.9-2012.7：博士，美国阿肯色大学 2005.9-2008.7：硕士，安徽医科大学，临床医学 2000.9-2005.7：学士，安徽医科大学，临床医学个人经历 2018.05-至今：北京理工大学生命学院，教授 2018:入选北京理工大学首批“特立青年学者” 2012-2018：美国西储大学(CWRU)和美国埃默里大学( Emory)博士后和科研助理工作社会/学术兼职其在J Oncol、 Tumor Biol等10个国际学术杂志及2个国际学术会议参与审稿了50余篇学术文章，并担任CMB杂志的客座编辑及 Annals of Mutagenesis杂志的编委

研究领域

多年来从事幼年型粒-单细胞白血病(JMML)发生发展的分子机制和相关药物开发的研究。主要研究内容是基因突变导致血液肿瘤的致病机制，以及针对肿瘤靶向蛋白的药物的开发和治疗。研究领域涉及白血病和实体肿瘤的发生，发展机理，磷酸酶的结构与活化、及其功能调控等

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Dong L#, Yu WM#, Zheng H#, Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature. 2016;539(7628):304-08. Dong L#, You S#, Zhang Q, Osuka S, Devi NS, Kaluz S, Holmes JN, Yang H, Chen G, Wang B, Grossniklaus HE, Van Meir EG. Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma. Clinical Cancer Research. 2019 Apr 1;25(7):2206-2218. Wu X, Dong L, Lin X, Li J. Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease. Front Immunol. 2017;8:1728. Dong L, Zheng H, Qu CK. CCL3 is a key mediator for the leukemogenic effect of Ptpn11 activating mutations in the stem cell microenvironment. Blood. 2017;130(12):1471-74. Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017;7:41718. Li XB#, Dong L#, Xu WR, Bhuyan SS, Chen CL, Wang RL. Study of SHP-2 (PTPN11) allosterism on structural movement using solution perturbed molecular dynamics simulation. Journal of Molecular Liquids. 2016;223:509-15. Wang M#, Li X#, Dong L#, Chen X, Xu W, Wang R. Virtual screening, optimization, and identification of a novel specific PTP-MEG2 Inhibitor with potential therapy for T2DM. Oncotarget. 2016;7(32):50828-34. Liu T, Li X, You S, Bhuyan SS, Dong L*. Effectiveness of AMD3100 in treatment of leukemia and solid tumors: from original discovery to use in current clinical practice. Exp Hematol Oncol. 2016;5:19. Chen L, Sun L, Dong L, Cui P, Xia Z, Li C, Zhu Y. The role of long noncoding RNA-LET in cell proliferation and invasion of nasopharyngeal carcinoma and its mechanism. Onco Targets Ther. 2017;10:2769-78. Gao L, Wu WF, Dong L, Ren GL, Li HD, Yang Q, Li XF, Xu T, Li Z, Wu BM, Ma TT, Huang C, Huang Y, Zhang L, Lv X, Li J, Meng XM. Protocatechuic Aldehyde Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Nox-Mediated Oxidative Stress and Renal Inflammation. Front Pharmacol. 2016;7:479. Yang P, Qiu Z, Jiang Y, Dong L, Yang W, Gu C, Li G, Zhu Y. Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/beta-catenin signaling pathway. Oncotarget. 2016;7(39):63449-55. Feng R, Dong L. Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. Int J Clin Exp Pathol. 2015;8(6):6107-16. Feng R, Dong L. Inhibitory effect of miR-184 on the potential of proliferation and invasion in human glioma and breast cancer cells in vitro. Int J Clin Exp Pathol. 2015;8(8):9376-82.