Hoffmeister, Dirk - Friedrich Schiller University

个人简介

2009-2014 Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena 2007-2009 Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA 2008 Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg 2004-2007 Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg 2002-2004 Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship) 2002 Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg 1998 Diploma in biology at the Eberhard-Karls-University, Tübingen Awards · Appointments · Scientific Activities Since 2020 Head of the Institute for Pharmacy, FSU Jena 2016-2019 Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena 2013-2016 Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).

研究领域

Biochemical and genetic basis of fungal natural product biosyntheses Natural products of basidiomycetes and Ralstonia solanacearum Microbial nonribosomal peptide synthetases

近期论文

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Löhr NA, Rakhmanov M, Wurlitzer JM, Lackner G, Gressler M, Hoffmeister D (2023) Basidiomycete non-reducing polyketide synthases function independently of SAT domains. Fungal Biol Biotechnol 10(1), 17. Schäfer E, Seibold PS, Bartram S, Trottmann F, Hänsch V, Gressler M, Chadeayne A, Hertweck C, O'Connor S, Hoffmeister D (2023) A "Magic Mushroom" multi-product sesquiterpene synthase. ChemBioChem [Accepted] Seibold PS, Lawrinowitz S, Raztsou I, Gressler M, Arndt HD, Stallforth P, Hoffmeister D (2023) Bifurcate evolution of quinone synthetases in basidiomycetes. Fungal Biol Biotechnol 10(1), 14. Wein P, Dornblut K, Herkersdorf S, Krüger T, Molloy EM, Brakhage AA, Hoffmeister D, Hertweck C (2023) Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease. mBio 14(4), e0078723. Yang YL, Zhou M, Yang L, Gressler M, Rassbach J, Wurlitzer JM, Zeng Y, Gao K, Hoffmeister D (2023) A mushroom P450-monooxygenase enables regio- and stereoselective biocatalytic synthesis of epoxycyclohexenones. Angew Chem Intl Ed Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249. Ezediokpu MN, Krause K, Kunert M, Hoffmeister D, Boland W, Kothe E (2022) Ectomycorrhizal influence on the dynamics of sesquiterpene release by Tricholoma vaccinum. J Fungi (Basel)8(6), 555. Kreuzenbeck NB, Seibel E, Schwitalla JW, Fricke J, Conlon BH, Schmidt S, Hammerbacher A, Köllner TG, Poulsen M, Hoffmeister D, Beemelmanns C (2022) Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites. mSystems 7(1), e0121421. Lawrinowitz S, Wurlitzer JM, Weiss D, Arndt, HD, Kothe E, Gressler M, Hoffmeister D (2022) Blue light-dependent pre-mRNA splicing controls pigment biosynthesis in the mushroom Terana caerulea. Microbiol Spectr 10(5), e0106522. Lenz C, Dörner S, Trottmann F, Hertweck C, Sherwood A, Hoffmeister D (2022) Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines. ChemBioChem 23(13), e202200183. Löhr NA, Eisen F, Thiele W, Platz L, Motter J, Hüttel W, Gressler M, Müller M, Hoffmeister D (2022) Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor. Angew Chem Int Ed 61(24), e202116142. Löhr NA, Urban MC, Eisen F, Platz L, Hüttel W, Gressler M, Müller M, Hoffmeister D (2022) The Ketosynthase Domain Controls Chain Length in Mushroom Oligocyclic Polyketide Synthases ChemBioChem , Schäfer T, Kramer K, Werten S, Rupp B, Hoffmeister D (2022) Characterization of the gateway decarboxylase for psilocybin biosynthesis. ChemBioChem 23(24), e202200551. Fricke J, Sherwood AM, Halberstadt AL, Kargbo RB, Hoffmeister D (2021) Chemoenzymatic synthesis of 5-methylpsilocybin: A tryptamine with potential psychedelic activity. J Nat Prod 84(4),1403-1408. Gressler M, Löhr NA, Schäfer T, Lawrinowitz S, Seibold PS, Hoffmeister D (2021) Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota. Nat Prod Rep 38(4), 702-722. Herkersdorf S, Krüger T, Wein P, Löffler S, Fontaine T, Gressler M, Hertweck C, Brakhage AA, Hoffmeister D (2021) Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis. Environ Microbiol 23(8), 4360-4371. Lenz C, Dörner S, Sherwood A, Hoffmeister D (2021) Structure elucidation and spectroscopic analysis of chromophores produced by oxidative psilocin dimerization. Chemistry 27(47),12166-12171. Lenz C, Sherwood A, Kargbo R, Hoffmeister D (2021) Taking different roads: L-Tryptophan as the origin of Psilocybe natural products. ChemPlusChem 86(1), 28-35. Mohr JF, Baldeweg F, Deicke M, Morales-Reyes CF, Hoffmeister D, Wichard T (2021) Frankobactin metallophores produced by nitrogen-fixing Frankia actinobacteria function in toxic metal sequestration. J Nat Prod 84(4), 1216-1225. Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734. Demmler R, Fricke J, Dörner S, Gressler M, Hoffmeister D (2020) S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms. ChemBioChem 21(9), 1364-1371. Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285. Lenz C, Wick J, Braga D, Garcia-Altares M, Lackner G, Hertweck C, Gressler M, Hoffmeister D (2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454. Seibold PS, Lenz C, Gressler M, Hoffmeister D (2020) The Laetiporus polyketide synthase LpaA produces a series of antifungal polyenes. J Antibiot 73(10), 711-720. Shah F, Gressler M, Nehzati S, Op De Beeck M, Gentile L, Hoffmeister D, Persson P, Tunlid A (2020) Secretion of iron(III)-reducing metabolites during protein acquisition by the ectomycorrhizal fungus Paxillus involutus. Microorganisms 9(1), E35. Baccile JA, Le HH, Pfannenstiel BT, Bok JW, Gomez C, Brandenburger E, Hoffmeister D, Keller NP, Schroeder FC (2019) Diketopiperazine formation in fungi requires dedicated cyclization and thiolation domains. Angew Chem Int Ed 58(41), 14589-14593. Baldeweg F, Hoffmeister D, Nett M (2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria. Nat Prod Rep 36(2), 307-325. Dörfer M, Gressler, M, Hoffmeister D (2019) Diversity and bioactivity of Armillaria sesquiterpene aryl ester natural products. Mycol Prog 18(8), 1027-1037. Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D (2019) Melleolides impact fungal translation via elongation factor 2. Org Biomol Chem 17(19),4906-4916. Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20(22),2824-2829. König S, Romp E, Krauth V, Rühl M, Dörfer M, Liening S, Hoffmann B, Häfner AK, Steinhilber D, Karas M, Garscha U, Hoffmeister D, Werz O (2019) Melleolides from honey mushroom inhibit 5-lipoxygenase via Cys159. Cell Chem Biol 26(1), 60-70.e4.