Fraser, Gareth - University of Sheffield - Department of Animal and Plant Sciences

个人简介

B.Sc. (Hons) - University of Portsmouth (2000) M.Res. – University of Glasgow (2001) Ph.D - King´s College London (2005) Post-Doctoral Research Fellow – Georgia Institute of Technology (2005-2009) Lecturer – University of Sheffield (2009 – present)

研究领域

Our research comprises three major areas of interest: (i) biodiversity and morphological evolution of fishes; (ii) comparative dental development and regeneration; and (iii) evolutionary developmental biology. We study the development of dental diversity across a range of vertebrates. Our lab questions how varieties of teeth are patterned and modified across species, how they form, and how they are replaced for continued production, specifically in fishes. Fishes account for more than half of all extant vertebrates and in addition have an immense diversity of dental form. The models that we study vary vastly from initial dental patterning and tooth number, to the capacity for dental regeneration with a diverse array of tooth replacement modes. This comparative context provides a framework in which to understand the complexities of dental diversity at the genetic level. Our broad research focus is the genetic basis of developmental mechanisms that regulate vertebrate craniofacial patterning and evolution. By coupling evolutionary and developmental genetic disciplines with more translational biosciences we aim to break down the complexities of morphological development, diversity and regeneration of the craniofacial skeleton, and in particular the dentition.

近期论文

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Gallego V, Yoshida M, Kurokawa D, Asturiano JF & Fraser GJ (2017) Embryonic development of the grass pufferfish (Takifugu niphobles): From egg to larvae. Theriogenology, 90, 191-196. Martin KJ, Rasch LJ, Cooper RL, Metscher BD, Johanson Z & Fraser GJ (2016) Sox2+ progenitors in sharks link taste development with the evolution of regenerative teeth from denticles.. Proc Natl Acad Sci U S A, 113(51), 14769-14774. Atkinson CJL, Martin KJ, Fraser GJ & Collin SP (2016) Morphology and distribution of taste papillae and oral denticles in the developing oropharyngeal cavity of the bamboo shark, Chiloscyllium punctatum. Biology Open. View this article in WRRO Hulsey CD, Fraser GJ & Meyer A (2016) Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions. Integrative and Comparative Biology, 56(3), 373-388. Rasch LJ, Martin KJ, Cooper RL, Metscher BD, Underwood CJ & Fraser GJ (2016) An ancient dental gene set governs development and continuous regeneration of teeth in sharks. Developmental Biology, 415(2), 347-370. View this article in WRRO Smith MM, Riley A, Fraser GJ, Underwood C, Welten M, Kriwet J, Pfaff C & Johanson Z (2015) Early development of rostrum saw-teeth in a fossil ray tests classical theories of the evolution of vertebrate dentitions. Proceedings of the Royal Society B: Biological Sciences, 282(1816), 20151628-20151628. View this article in WRRO Underwood CJ, Johanson Z, Welten M, Metscher B, Rasch LJ, Fraser GJ & Smith MM (2015) Development and Evolution of Dentition Pattern and Tooth Order in the Skates And Rays (Batoidea; Chondrichthyes). PLOS ONE, 10(4), e0122553-e0122553. View this article in WRRO