Fleming, Andrew - University of Sheffield - Department of Animal and Plant Sciences

个人简介

Professor of Plant Science, University of Sheffield (2004-present) Group Leader, ETH-Zurich, Switzerland (1997-2004) Habilitation, University of Bern, Switzerland (1996) Assistant, University of Bern, Switzerland (1989 - 1996) Postdoctorate, ETH-Zurich, Switzerland (1988) PhD Cambridge (1987) BA Cambridge (1984)

研究领域

Our research is focussed on understanding the mechanism of plant morphogenenesis. In particular, we are interested in understanding the interplay of cell growth and division and how these parameters are integrated into the developmental program controlling leaf size and shape. Using techniques of cell and molecular biology, we are testing hypotheses on the regulation of organogenesis. At the same time, these approaches provide functional data on gene products implicated in basic aspects of the plant cell cycle and the plant cell wall. Our focus is on an integrative approach in which, in addition to cell and molecular techniques, we are incorporating computational modeling, physiology and biochemistry to provide an organismal-level understanding of leaf formation and function. In addition, as a result of our interest in cell division and the cell wall and how they are integrated into plant function, we have become involved in a range of collaborative ventures. For example, the interplay between development, physiology and metabolism has led to novel joint projects aimed at developing/implementing techniques for the visualization and analysis of metabolites at the cellular level and their integration with developmental processes (Paul Quick, Mike Burrell). The cell wall also plays an important role in the functioning of specific cell types required for leaf function and this has led to joint EvoDevo projects looking at aspects of plant evolution (David Beerling, Julie Gray, Charles Wellman). The group has a strong tradition of pan-European research. If you are interested in applying for a EU-Marie Curie Fellowship to work with us, don´t hesitate to make contact.

近期论文

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Amsbury S, Hunt L, Elhaddad N, Baillie A, Lundgren M, Verhertbruggen Y, Scheller HV, Knox JP, Fleming AJ & Gray JE (2016) Stomatal Function Requires Pectin De-methyl-esterification of the Guard Cell Wall. Current Biology. View this article in WRRO Caine R, Chater CC, Kamisugi Y, Cuming AC, Beerling DJ, Gray JE & Fleming AJ (2016) An ancestral stomatal patterning module revealed in the non-vascular land plant Physcomitrella patens.. Development, 143, 3306-3314. View this article in WRRO van Campen J, Yaapar MN, Narawatthana S, Lehmeier C, Wanchana S, Thakur V, Chater C, Kelly S, Rolfe SA, Quick WP & Fleming AJ (2016) Combined Chlorophyll Fluorescence and Transcriptomic Analysis Identifies the P3/P4 Transition as a Key stage in Rice Leaf Photosynthetic Development. Plant Physiology, pp.01624.2015-pp.01624.2015. View this article in WRRO Chater CC, Caine RS, Tomek M, Wallace S, Kamisugi Y, Cuming AC, Lang D, MacAlister CA, Casson S, Bergmann DC, Decker EL, Frank W, Gray JE, Fleming A, Reski R & Beerling DJ (2016) Origin and function of stomata in the moss Physcomitrella patens.. Nat Plants, 2, 16179-16179. Fleming A (2015) Sweet size control in tomato. Nature Genetics, 47(7), 698-699. Kasprzewska A, Carter R, Swarup R, Bennett M, Monk N, Hobbs JK & Fleming A (2015) Auxin influx importers modulate serration along the leaf margin. The Plant Journal, 83(4), 705-718. View this article in WRRO Wallace S, Chater CC, Kamisugi Y, Cuming AC, Wellman CH, Beerling DJ & Fleming AJ (2015) Conservation of Male Sterility 2 function during spore and pollen wall development supports an evolutionarily early recruitment of a core component in the sporopollenin biosynthetic pathway. New Phytologist, 205(1), 390-401. Goh H-H, Sloan J, Malinowski R & Fleming A (2014) Variable expansin expression in Arabidopsis leads to different growth responses. JOURNAL OF PLANT PHYSIOLOGY, 171(3-4), 329-339.