沈杰 - 中国农业大学 - 植物保护学院

个人简介

工作经历 2009.05至今中国农业大学教授 2006.03-2009.04 德国美因茨大学博士后 2005.01-2005.12 瑞士日内瓦大学博士后教育经历 2001.08-2004.11 德国马普协会分子细胞生物学与遗传学研究所博士 1997.09-2000.06 中国农业大学硕士 1990.09-1994.06 中国农业大学本科学术兼职中国植物保护学会副理事长，中国昆虫学会常务理事，北京市昆虫学会常务理事《植物保护学报》副主编，《昆虫学报》编委，《应用昆虫学报》编委，《环境昆虫学报》编委科研项目国家自然科学基金，北京市自然科学基金，教育部博士点基金，教育部留学回国基金，公益性行业专项，973计划，国家重点研发计划，教育部新世纪优秀人才等奖励情况 2015年大北农科技奖创新奖二等奖，2017第二届中国科协优秀科技论文遴选计划农林集群优秀论文二等奖，2016年度《植物保护学报》优秀论文，2016年中国农业大学优秀共产党员

研究领域

昆虫发育生物学：以果蝇为模型，研究癌症和衰老相关基因的作用机理农业昆虫功能基因组学：揭示农业昆虫的生长发育和繁殖调控途径，解析关键调控基因的功能植保新技术：研发纳米材料为载体的新型杀虫剂和新型RNAi喷雾剂，扩大杀虫普、提高农药效率、降低使用量，干扰害虫的关键基因、遗传学技术控制害虫

近期论文

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Extrusion of Cells with Inappropriate Dpp Signaling from Drosophila Wing Disc Epithelia Fluorescent Nanoparticle Delivered dsRNA Toward Genetic Control of Insect Pests Development of an Amino Acid-Functionalized Fluorescent Nanocarrier to Deliver a Toxin to Kill Insect Pests A gene and drug co-delivery application helps to solve the short life disadvantage of RNA drug A Facile-Synthesized Star Polycation is Constructed as A Highly Efficient Gene Vector in Pest Management The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging International Journal of Molecular Sciences Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant The Wnt pathway regulates wing morph determination in Acyrthosiphon pisum A Nano-Delivery System Enhances the Stomach Toxicity of Methoxyfenozide against Spodoptera litura by Suppressing the Synthesis of Insect Cuticle Protein NPFR regulates the synthesis and metabolism of lipids and glycogen via AMPK: Novel targets for efficient corn borer management Self-Assembled Nanonematicide Induces Adverse Effects on Oxidative Stress, Succinate Dehydrogenase Activity, and ATP Generation An AIE Star Polymer with Enhanced Co‐Delivery of Drug and Gene for Synergistic Pest Control ? 器官的构造是如何形成的以果蝇翅为例器官成形素调控果蝇翅芽细胞形貌的研究进展-2013 遗传学策略在昆虫学中的最新应用 # Current progress of genetic strategies in entomological research Research Status and Development Prospect of RNA Pesticide 草地贪夜蛾潜在 RNAi 靶标致死基因及纳米载体介导 RNAi 技术的应用和展望 Potential RNAi target lethal genes of fall armyworm Spodoptera frugiperda and the application and prospect of nanocarrier-mediated RNAi technology 纳米农药及载体材料的增效机理研究现状沈杰基于纳米递送系统的 RNA 农药及转基因植物研究进展 Research progress in nano-delivery system-based RNA pesticides and transgenic plants 果蝇基因组与功能基因研究进展农业昆虫的功能基因组学研究回顾与展望周行 Present status and perspectives of the researches on insect wing development 害虫遗传学控制策略与进展 BrdU抗体染色技术检测昆虫器官的细胞增殖-c1f627dc Comparative analysis of the occurrence and control of pests and diseases in four major potato producing areas in China in recent years Self-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae The mitochondrial ribosomal protein mRpL4 regulates Notch signaling Multifunctional Nanoparticles and Nanopesticides in Agricultural Application Tweedle gene family of Drosophila suzukii (Matsumura) larva enhances the basal tolerance to cold and hypoxia Establishment of star polycation-based RNA interference system in all developmental stages of fall armyworm Spodoptera frugiperda The transcription factor optomotor-blind restricts apterous expression through TrxG and PcG genes International Journal of Molecular Sciences Review Recent Advances in Nanoparticle-Mediated Co-Delivery System: A Promising Strategy in Medical and Agricultural Field Open Access Nanoparticle carriers enhance RNA stability and uptake efficiency and prolong the protection against Rhizoctonia solani Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster Calcium nutrition nanoagent rescues tomatoes from mosaic virus disease by accelerating calcium transport and activating antiviral immunity Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading A nano-delivery system expands the insecticidal target of thiamethoxam to include a devastating pest fall armyworm Nanoparticle-based nontransformative RNA insecticides for sustainable pest control: mechanisms, current status and challenges The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality in Aphis gossypii Nanodelivery System Alters an Insect Growth Regulator’s Action Mode: From Oral Feeding to Topical Application A Preparation Method of Nano-Pesticide Improves the Selective Toxicity toward Natural Enemies Nanocarrier-Loaded Imidaclothiz Promotes Plant Uptake and Decreases Pesticide Residue Use of FLP/FRT System to Screen for Notch Signaling Regulators in the Drosophila Wing Construction and application of star polycation nanocarrier-based microRNA delivery system in Arabidopsis and maize A Star Polyamine-Based Nanocarrier Delivery System for Enhanced Avermectin Contact and Stomach Toxicity against Green Peach Aphids The Tbx6 Transcription Factor Dorsocross Mediates Dpp Signaling to Regulate Drosophila Thorax Closure Combination of a nanocarrier delivery system with genetic manipulation further improves pesticide efficiency: a case study with chlorfenapyr Nanocarrier-mediated transdermal dsRNA-NPF1 delivery system contributes to pest control via inhibiting feeding behavior in Grapholita molesta Efficient polymer-mediated delivery system for thiocyclam: Nanometerization remarkably improves the bioactivity toward green peach aphids A first greenhouse application of bacteria-expressed and nanocarrier-delivered RNA pesticide for Myzus persicae control Biotoxicity Evaluation of a Cationic Star Polymer on a Predatory Ladybird and Cooperative Pest Control by Polymer-Delivered Pesticides and Ladybird Nanocarrier-pesticide delivery system with promising benefits in a case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue JAK/STAT signaling regulates the Harmonia axyridis leg regeneration by coordinating cell proliferation Application of Nanoparticle-Mediated RNAi for Efficient Gene Silencing and Pest Control on Soybean Aphids Phenotypical and genetical characterization of the Mad allele during Drosophila wing development The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Drosophila Wing Development Fine Structure and Olfactory Reception of the Labial Palps of Spodoptera frugiperda Field application of star polymer-delivered chitosan to amplify plant defense against potato late blight Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry Nanocarrier-delivered dsRNA suppresses wing development of green peach aphids A potential genetic control by suppression of the wing developmental gene wingless in a global invasive pest Bactrocera dorsalis Hedgehog signaling regulates regenerative patterning and growth in Harmonia axyridis leg Characterization of a new mastermind allele identified from somatic mosaic screen The Ras/MAPK pathway is required for regenerative growth of wing discs in the black cutworm Agrotis ypsilon T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner Research progress of RNA insecticides Nanometerization of thiamethoxam by a cationic star polymer nanocarrier efficiently enhances the contact and plant-uptake dependent stomach toxicity against green peach aphids Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management Reproductive polyphenism and its advantages in aphids: Switching between sexual and asexual reproduction An Orphan Pheromone Receptor Affects the Mating Behavior of Helicoverpa armigera Improving RNAi efficiency for pest control in crop species The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila A novel plasmid-Escherichia coli system produces large batch dsRNAs for insect gene silencing Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK/Caspase signaling in the Drosophila wing disc Spray method application of transdermal dsRNA delivery system for efficient gene silencing and pest control on soybean aphid Aphis glycines Effects of Paranosema locustae (Microsporidia) on the development and morphological phase transformation of Locusta migratoria (Orthoptera: Acrididae) through modulation of the neurotransmitter taurine Decapentaplegic signaling regulates Wingless ligand production and target activation during Drosophila wing development A Star Polycation Acts as a Drug Nanocarrier to Improve the Toxicity and Persistence of Botanical Pesticides Flexible manipulation of Omb levels in the endogenous expression region of Drosophila wing by combinational over-expression and suppression strategy Three Melanin Pathway Genes, TH, yellow, and aaNAT, Regulate Pigmentation in the Twin-Spotted Assassin Bug, Platymeris biguttatus (Linnaeus) A polymer/detergent formulation improves dsRNA penetration through the body wall and RNAi-induced mortality in the soybean aphid Aphis glycines Design and Synthesis of a Fluorescent Amino Poly (glycidyl methacrylate) for Efficient Gene Delivery 基于工程菌高效合成靶向昆虫基因的 dsRNA 的方法 * 摘要 RNA(dsRNA) RNA (RNAi) dsRNA RNAi L4440 HT115(DE3) dsRNA dsRNA dsRNA dsRNA RNAi RNAi 关键词 RNA dsRNA L4440 HT115(DE3) An efficient dsRNA production method based on engineering bacteria for targeted insect genes 纳米技术在害虫绿色防控领域的应用与展望 * 摘要 dsRNA DNA Bt Prospects for the application of nanotechnology in green pest control Behavioral thermoregulation in Locusta migratoria manilensis (Orthoptera: Acrididae) in response to the entomopathogenic fungus, Beauveria bassiana Comparative Transcriptome Analyses Uncover Key Candidate Genes Mediating Flight Capacity in Bactrocera dorsalis (Hendel) and Bactrocera correcta (Bezzi) (Diptera: Tephritidae) Hedgehog signalling is required for cell survival in Drosophila wing pouch cells spalt is functionally conserved in Locusta and Drosophila to promote wing growth