MacNeil, Sheila - University of Sheffield - Department of Materials Science and Engineering

个人简介

Sheila MacNeil is Professor of Tissue Engineering in the Department of Materials Science and Engineering, joining the department in 2000. She has an undergraduate degree in physiology from the University of Aberdeen and a doctorate on the endocrinology of manic depression from the Medical School of the University of Sheffield. She is academic lead of the Biomaterials and Tissue Engineering Group within the Department. Members of this group: Professor John Haycock, Readers Dr Ihtesham Rehman, Dr Steve Matcher and Senior Lecturers Dr CK Chong, Dr Frederik Claeyssens, Dr Gwen Reilly. She has previously been Deputy Director of the Kroto Research Institute (from 2005 to 2009) and Director of the University Centre for Biomaterials and Tissue Engineering from 2002 to 2009, promoting interdisciplinary research between engineering, physical sciences and life sciences. She was also a founding Director of the University of Sheffield spin-out company, CellTran Limited from 2000 to 2007. She was the Sheffield lead for an EPSRC Doctoral Training Centre in Tissue Engineering and Regenerative Medicine (a DTC held between three Universities, Leeds, Sheffield and York) from 2008 to 2011.

研究领域

Her research focuses on developing tissue engineering which will benefit patients, alongside fundamental work to develop new understanding and tools in the area of tissue engineering. Her primary research interests are in tissue engineering of soft tissues – skin, oral mucosa, urethra and cornea, with a strong focus on translating research for clinical benefit. Her group have a long history of working with clinical NHS colleagues using tissue engineered skin to benefit burns patients (from 1992) and more recently patients with chronic ulcers (2004) and patients requiring reconstructive surgery of the urethra (from 2007). She has developed the product Myskin™ which was clinically evaluated and developed commercially and has been available in the UK for patients with extensive skin loss due to burns injuries and to chronic non-healing ulcers from 2004 to the current time, currently available through the company Regenerys Ltd. Additionally she has developed 3D tissue engineered models used to study a wide range of normal and abnormal conditions spanning wound healing, skin contracture, pigmentation, melanoma invasion, angiogenesis, bacterial infection and skin sensitisation.

近期论文

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Deshpande P, Ramachandran C, Sefat F, Mariappan I, Johnson C, McKean R, Hannah M, Sangwan VS, Claeyssens F, Ryan AJ, MacNeil S. Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants. Biomaterials. 34(21): 5088-5106 (2013) Ortega I, Ryan AJ, Deshpande P, MacNeil S, Claeyssens F. Combined microfabrication and electrospinning to produce 3-D architectures for corneal repair. Acta Biomaterialia. 9(3):5511-5520 (2013) Roman S, Mangera A, Osman NI, Bullock AJ, Chapple CR, Macneil S. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse-which cell source? Neurourol Urodyn.33(5):531-7 (2013) Sangwan VSS, Jain R, Basu S, Bagadi AB, Sureka S, Mariappan I, MacNeil S. Transforming ocular surface stem cell research into successful clinical practice. Indian Journal of Ophthalmology. 62(1):29-40 (2014). Hassan E, Deshpande P, Claeyssens F, Rimmer S, MacNeil S. Amine functional hydrogels as selective substrates for corneal epithelialisation. Acta Biomaterialia 10:3029–3037 (2014)