Haycock, John W - University of Sheffield - Department of Materials Science and Engineering

个人简介

John Haycock is a Professor in the Department Materials Science & Engineering, and Director of the Centre for Biomaterials & Tissue Engineering. He joined the department in 2001 from the Medical School at Sheffield University where he was a Research Fellow. He obtained his first degree and PhD in Biochemistry at Newcastle University and was a PDRA at Albany Medical College in New York. His research group is based in the Kroto Research Institute. John is Director of Research for Materials Science and Engineering.

研究领域

John's research spans five interdisciplinary themes: 1. Nerve tissue engineering. The design of nerve guidance channels for repairing traumatic peripheral nerve injury – combining biomaterials, 3D fabrication, neuronal, glial and stem cell research. 2. 3D In vitro models of nerve. The use of 3D scaffolds and neuronal / glial co-cultures for 3D in vitro models of nerve as an alternative to animal models for disease, disorder and testing research. 3. 3D In vitro models of skin. The use of 3D scaffolds and keratinocyte / fibroblast co-cultures for 3D in vitro models of skin as an alternative to animal models for inflammatory testing. 4. 3D Imaging. Confocal and 2-photon microscopy + Time resolved microcopy imaging 5. Bioactive surfaces. Anti-inflammatory and anti-microbial surfaces for medical applications John also has an interest in single and 2-photon laser scanning microscopy for supporting a number of interdisciplinary research programmes, including tissue engineering. He was responsible for establishing the confocal and multiphoton imaging facility in the Kroto Research Institute funded by the BBSRC with support from Carl Zeiss.

近期论文

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Hopper, A.P., Dugan, J.M, Gill, A.A., Fox, O.J.L., May, P.W., Haycock, J.W., Claeyssens, F. Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth. Biomedical Materials, 9(4); 045009. Harrington, H., Cato, P., Salazar, F., Wilkinson, M, Knox, A., Haycock, J.W., Rose, F., Aylott, J.W., Ghaemmaghami, A.M (2014) Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation. Molecular Pharmaceutics, 11(7), 2082-2091. Baggaley, E., Gill, M.R., Green, N.H., Turton, D., Sazanovich, I.V., Botchway, S.W., Smythe, C., Haycock, J.W., Weinstein, J.A., Thomas, J.A. (2014) Dinuclear Ruthenium(II) Complexes as Two-Photon, Time-Resolved Emission Microscopy Probes for Cellular DNA. Angewandte Chemie International. 53(13), 3367-3371. Baggaley, E, Sazanovich, I.V., Williams, J.A.G., Haycock, J.W., Botchway, S.W., Weinstein, J.A. (2014) Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated Npyridyl^Cphenyl^N pyridyl Pt(ii) complex RSC Advances, 4(66); 35003-35008. Baggaley, E., Sasanovich, I., Botchway, S., Haycock, J.W., Williams, J.A.G., Weinstein, J. (2014) Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: from FLIM to PLIM and beyond. Chemical Science; 5 (3), 879 - 886.