Williamson, Mike - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2001 - present: Professor, University of Sheffield 1993 - 2001: Reader, University of Sheffield 1990 - 1993: Senior Lecturer, University of Sheffield 1984 - 1990: Team Leader, Bio-NMR, Roche Products Ltd, UK 1981 - 1984: Junior Research Fellow, Churchill College Cambridge, and SERC/NATO Overseas Research Fellow at ETH Zurich

研究领域

Protein structure determination, protein mobility and interactions with ligands by 2D and 3D NMR. Targets include bacterial pathogenesis proteins and human disease-state proteins.

近期论文

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Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga J-P, Wessely O, Williamson MP & Ong ACM (2016) The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking. Journal of the American Society of Nephrology, 27(4), 1159-1173. Asakura T, Okushita K & Williamson MP (2015) Analysis of the Structure of Bombyx mori Silk Fibroin by NMR. Macromolecules, 48(8), 2345-2357. Mesnage S, Dellarole M, Baxter NJ, Rouget JB, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K, Foster SJ & Williamson MP (2014) Molecular basis for bacterial peptidoglycan recognition by LysM domains.. Nat Commun, 5, 4269. View this article in WRRO Wilson T, Costa PJ, Félix V, Williamson MP & Thomas JA (2013) Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence.. J Med Chem, 56(21), 8674-8683. View this article in WRRO Williamson MP, Hounslow AM, Ford J, Fowler K, Hebditch M & Hansen PE (2013) Detection of salt bridges to lysines in solution in barnase.. Chem Commun (Camb), 49(84), 9824-9826. Williamson MP (2013) Using chemical shift perturbation to characterise ligand binding.. Prog Nucl Magn Reson Spectrosc, 73, 1-16. Kitahara R, Hata K, Li H, Williamson MP & Akasaka K (2013) Pressure-induced chemical shifts as probes for conformational fluctuations in proteins. Progress in Nuclear Magnetic Resonance Spectroscopy, 71, 35-58. Moody RG & Williamson MP (2013) Structure and function of a bacterial Fasciclin I Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin. FEBS Open Bio, 3, 71-77. View this article in WRRO Asakura T, Okonogi M, Horiguchi K, Aoki A, Saito H, Knight DP & Williamson MP (2012) Two Different Packing Arrangements of Antiparallel Polyalanine. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(5), 1212-1215. Tomlinson JH & Williamson MP (2011) Amide temperature coefficients in the protein G B1 domain. Journal of Biomolecular NMR, 1-8. Trotter EW, Rolfe MD, Hounslow AM, Craven CJ, Williamson MP, Sanguinetti G, Poole RK & Green J (2011) Reprogramming of escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment. PLoS ONE, 6(9). View this article in WRRO