West, Steven - University of Sheffield - Department of Molecular Biology and Biotechnology

研究领域

RNA processes linked to human disease, such as CTD kinase regulation in Amyotrophic Lateral Sclerosis and Oculopharyngeal Muscular Dystrophy; pre-mRNA processing, maturation, quality control and degradation.

近期论文

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Muniz L, Davidson L & West S (2015) Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. Molecular and Cellular Biology, 35(13), 2218-2230. View this article in WRRO Davidson L, Muniz L & West S (2014) 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Genes & Development, 28(4), 342-356. Hett A & West S (2014) Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus. PLoS ONE, 9(5), e96174-e96174. View this article in WRRO Davidson L & West S (2013) Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision. Nucleic Acids Research, 41(14), 7101-7114. View this article in WRRO Davidson L, Kerr A & West S (2012) Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. The EMBO Journal, 31(11), 2566-2578. West S (2012) The increasing functional repertoire of U1 snRNA. Biochemical Society Transactions, 40(4), 846-849. Schmidt M-J, West S & Norbury CJ (2011) The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA, 17(1), 39-44. West S & Proudfoot NJ (2009) Transcriptional Termination Enhances Protein Expression in Human Cells. Molecular Cell, 33(3), 354-364. West S & Proudfoot NJ (2008) Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. Nucleic Acids Research, 36(3), 905-914. View this article in WRRO West S, Proudfoot NJ & Dye MJ (2008) Molecular Dissection of Mammalian RNA Polymerase II Transcriptional Termination. Molecular Cell, 29(5), 600-610. West S, Gromak N, Norbury CJ & Proudfoot NJ (2006) Adenylation and Exosome-Mediated Degradation of Cotranscriptionally Cleaved Pre-Messenger RNA in Human Cells. Molecular Cell, 21(3), 437-443. WEST S (2006) Transcriptional termination sequences in the mouse serum albumin gene. RNA, 12(4), 655-665. Gromak N, West S & Proudfoot NJ (2006) Pause Sites Promote Transcriptional Termination of Mammalian RNA Polymerase II. Molecular and Cellular Biology, 26(10), 3986-3996.