Waltho, Jon - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2009: Awarded the Gibson Chair of Biophysics 2008: Professorial Appointment in Faculty of Life Sciences, University of Manchester 1999: Awarded a Personal Chair in Molecular Biology and Biotechnology 1997: Promoted to a Readership 1996: Awarded a Research Fellowship by the Lister Institute of Preventive Medicine 1996: Promoted to a Senior Lectureship 1990: Awarded a Krebs Institute Lectureship in the Department of Molecular Biology and Biotechnology, University of Sheffield 1987 - 90: Postdoctoral research assistant, with Dr P. E. Wright, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 1986 - 87: Postdoctoral research assistant, with Dr J. G. Vinter, SmithKline French Research 1983 - 86: Postgraduate studentship, SERC funded, with Dr D. H. Williams in the University Chemical Laboratory and Emmanual College, Cambridge 1980 - 83: B.Sc. Honours degree in Chemistry, Class I, at Grey College, Durham

研究领域

Application of multidimensional NMR methods to solving protein structures, complex formation, kinetics, protein molecular recognition and transition states, particularly in kinases.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Czarnota S, Baxter NJ, Cliff MJ, Waltho JP, Scrutton NS & Hay S (2016) (1)H, (15)N, (13)C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol.. Biomol NMR Assign. Blackburn GM, Jin Y, Richards NG & Waltho JP (2016) Metal Fluorides as Analogs for Studies on Phosphoryl Transfer Enzymes. Angewandte Chemie International Edition. Jin Y, Molt RW, Waltho JP, Richards NGJ & Blackburn GM (2016) 19 F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis. Angewandte Chemie International Edition, 55(10), 3318-3322. View this article in WRRO Briggs DC, Birchenough HL, Ali T, Rugg MS, Waltho JP, Ievoli E, Jowitt TA, Enghild JJ, Richter RP, Salustri A, Milner CM & Day AJ (2015) Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix. Journal of Biological Chemistry, 290(48), 28708-28723. Davis PJ, Holmes D, Waltho JP & Staniforth RA (2015) Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology. Journal of Molecular Biology, 427(15), 2418-2434. Kiraly P, Adams RW, Paudel L, Foroozandeh M, Aguilar JA, Timári I, Cliff MJ, Nilsson M, Sándor P, Batta G, Waltho JP, Kövér KE & Morris GA (2015) Real-time pure shift 15N HSQC of proteins: a real improvement in resolution and sensitivity. Journal of Biomolecular NMR, 62(1), 43-52. Volk M, Milanesi L, Waltho JP, Hunter CA & Beddard GS (2015) The roughness of the protein energy landscape results in anomalous diffusion of the polypeptide backbone. Phys. Chem. Chem. Phys., 17(2), 762-782. Trevitt CR, Hosszu LLP, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP & Clarke AR (2014) N-terminal Domain of Prion Protein Directs Its Oligomeric Association. Journal of Biological Chemistry, 289(37), 25497-25508.