杜敏敏 - 中国农业大学

个人简介

科研工作杜敏敏博士长期以番茄为主要对象，研究植物激素介导的生长和防御机制，同时还开展番茄分子育种相关的应用研究工作。代表性研究成果包括：1）揭示了生长素介导的双子叶植物幼苗顶端弯钩的形成机制；2）阐明了茉莉酸介导的抗病反应的激活、级联放大及终止的转录调控机制；3）建立了一种快速创制番茄雄性不育系并用于杂交种子生产的技术体系。以第一或通讯作者（含并列）在Science Advances、Annual Review of Plant Biology、Plant Cell（3篇）、Plant Journal和Theoretical and Applied Genetics等期刊发表学术论文8篇。相关成果获得中国发明专利2项并申请美国专利1项；曾主持国家自然科学基金面上项目和国家重点研发计划子课题各1项科研项目中国农业大学杰出人才项目“番茄果实发育及品质形成的时空调控机理” （2022-2027）主持国家自然科学基金面上项目 “番茄转录因子JA5负向调控灰霉病抗性反应的分子机制”（2017-2020）主持国家重点研发计划子课题 “番茄杂种优势利用技术与强优势杂交种创制” （2017-2020）主持

研究领域

番茄果实发育、品质形成与分子育种

近期论文

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(#first authors, *corresponding authors) Du M#, Bou Daher F#, Liu Y, Steward A, Tillmann M, Zhang X, Wong JH, Ren H, Cohen J, Li C*, Gray W*. Biphasic control of cell expansion by auxin coordinates etiolated seedling development. Science Advances, 2022, 8(2), p.eabj1570. Yang H#, Wang H#, Jiang J, Liu M, Liu Z, Tan Y, Zhao T, Zhang H, Chen X, Li J, Wang A*, Du M* and Xu X*. The Sm gene conferring resistance to gray leaf spot disease encodes a NBS-LRR plant resistance protein in tomato. Theoretical and Applied Genetics, 2022. Du M#, Spalding E and Gray W*. Rapid auxin-mediated cell expansion. Annual Review of Plant Biology, 2020, 71:379-402. Du M#*, Zhou K#, Liu Y#, Deng L#, Zhang X, Lin L, Zhou M, Zhao W, Wen C, Xing J, Li C-B* and Li C*. A biotechnology-based male sterility system for hybrid seed production in tomato. Plant Journal, 2020, 102:1090-1100. Sun C#, Deng L#, Du M, Zhao J, Chen Q, Huang T, Jiang H, Li C-B* and Li C*. A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Molecular Plant, 2020, 13:42-58. Liu Y#, Du M#, Deng L#, Shen J, Fang M, Chen Q, Lu Y, Wang Q, Li C* and Zhai Q*. MYC2 regulates the termination of jasmonate signaling via an autoregulatory negative feedback loop. Plant Cell, 2019, 31:106-127. Wong J#, Spartz A#, Park M, Du M and Gray W*. Mutation of a conserved motif of PP2C.D phosphatases confers SAUR immunity and constitutive activity. Plant Physiology, 2019, 181：353-366. Deng L#, Wang H#, Sun C, Li Q, Jiang H, Du M, Li C-B and Li C. Efficient generation of pink-fruited tomatoes using CRISPR/Cas9 system. Journal of Genetics and Genomics, 2018, 45: 51-54. Du M#, Zhao J#, Tzeng D, Liu Y, Deng L, Zhai Q, Wu F, Huang Z, Zhou M, Wang Q, Chen Q, Zhong S, Li C-B and Li C. MYC2 orchestrates a hierarchical transcriptional cascade that regulates jasmonate-mediated plant immunity in tomato. Plant Cell, 2017, 29:1883-1906. Du M#, Zhai Q#, Deng L, Li S, Li H, Yan L, Huang Z, Wang B, Jiang H, Huang T, Li C-B, Wei J, Kang K, Li J and Li C. Closely-related NAC transcription factors of tomato differentially regulate stomatal closure and reopening during pathogen attack. Plant Cell, 2014, 26: 3167-3184.