Staniforth, Rosie - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2010 - present: Lecturer, University of Sheffield 2001 - 2010: Royal Society University Research Fellow, University of Sheffield 2000 - 2000: Wellcome Career Development Fellow University of Sheffield 1997 - 2000: PDRA, Dept. Molecular Biology and Biotech., University of Sheffield 1994 - 1997: Wellcome Trust Travelling Research Fellow to Europe, University of Rome “La Sapienza”, Italy 1994 - 1994: PDRA Dept. Biochemistry, University of Bristol

研究领域

Structural and mechanistic studies on the mechanism of amyloid fibril formation, the precursor to neurodegenrative conditions including Alzheimer's disease.

近期论文

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Dennison AJC, Jones RAL, Staniforth RA & Parnell AJ (2016) Interaction of partially denatured insulin with a DSPC floating lipid bilayer. Soft Matter, 12(3), 824-829. View this article in WRRO Davis PJ, Holmes D, Waltho JP & Staniforth RA (2015) Limited Proteolysis Reveals That Amyloids from the 3D Domain-Swapping Cystatin B Have a Non-Native β-Sheet Topology. Journal of Molecular Biology, 427(15), 2418-2434. Taler-Verčič A, Kirsipuu T, Friedemann M, Noormägi A, Polajnar M, Smirnova J, Znidarič MT, Zganec M, Skarabot M, Vilfan A, Staniforth RA, Palumaa P & Zerovnik E (2013) The role of initial oligomers in amyloid fibril formation by human stefin B.. Int J Mol Sci, 14(9), 18362-18384. Paramore R, Morgan GJ, Davis PJ, Sharma CA, Hounslow A, Taler-Verčič A, Žerovnik E, Waltho JP, Cliff MJ & Staniforth RA (2012) Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions. Frontiers in Molecular Neuroscience(OCTOBER 2012). Jelinska C, Davis PJ, Kenig M, Zerovnik E, Kokalj SJ, Gunčar G, Turk D, Turk V, Clarke DT, Waltho JP & Staniforth RA (2011) Modulation of contact order effects in the two-state folding of stefins A and B.. Biophys J, 100(9), 2268-2274. Žerovnik E, Stoka V, Mirtič A, Gunčar G, Grdadolnik J, Staniforth RA, Turk D & Turk V (2011) Mechanisms of amyloid fibril formation--focus on domain-swapping.. FEBS J, 278(13), 2263-2282. Zerovnik E, Staniforth RA & Turk D (2010) Amyloid fibril formation by human stefins: Structure, mechanism & putative functions.. Biochimie, 92(11), 1597-1607. Žerovnik E, Staniforth RA & Turk D (2010) Amyloid fibril formation by human stefins: Structure, mechanism & putative functions. Biochimie, 92(11), 1597-1607. Milanesi L, Jelinska C, Hunter CA, Hounslow AM, Staniforth RA & Waltho JP (2008) A method for the reversible trapping of proteins in non-native conformations.. Biochemistry, 47(51), 13620-13634. Morgan GJ, Giannini S, Hounslow AM, Craven CJ, Zerovnik E, Turk V, Waltho JP & Staniforth RA (2008) Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.. J Mol Biol, 375(2), 487-498.