Rice, David - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2008 - present: Harrison Chair in Structural Biology, University of Sheffield 1996 - 2007: Chairman of the Department of Molecular Biology and Biotechnology, University of Sheffield 1993 - 2007: Director of the Krebs Institute for Biomolecular Research, University of Sheffield 1990: Visiting Professor - Dept. of Biochemistry and Biophysics Washington State University, USA 1988 - 93: Research Fellow of the Lister Institute of Preventive Medicine, University of Sheffield 1984 - 87: Science and Engineering Research Council Special Replacement Lecturer, University of Sheffield 1987: Visiting Lecturer - Dept. of Chemistry and Biochemistry Massey University, New Zealand. 1981 - 84: Independent Research Worker, University of Sheffield. 1979 - 81: Postdoc, Laboratory of Molecular Biophysics, Oxford 1979: D.Phil., St. Catherine's College, Oxford 'X-ray crystallographic studies on the sequence, structure and activity of horse muscle phosphoglycerate kinase' 1971 - 75: B.A. Honours Chemistry, St. Catherine's College, Oxford

研究领域

X-ray crystallography in the analysis of enzyme structure and function to develop an understanding of basic biological mechanisms for rational design of new drugs and the use of enzymes for industrial and biomedical applications.

近期论文

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Rust A, Hassan HHA, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T & Davletov B (2015) Two complementary approaches for intracellular delivery of exogenous enzymes. Scientific Reports, 5, 12444-12444. View this article in WRRO Bisson C, Britton KL, Sedelnikova SE, Rodgers HF, Eadsforth TC, Viner RC, Hawkes TR, Baker PJ & Rice DW (2015) Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination. Structure, 23(7), 1236-1245. View this article in WRRO Wilkinson C, Rawson S, Muench SP, McPhillie MJ, Rice DW, Zhou Y, McLeod R, Woods S, Khaliq F, Roberts CW, Afanador GA, Prigge ST & Fishwick CW (2014) The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorganic and Medicinal Chemistry Letters. Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, Rice DW, Freire E, McLeod R & Prigge ST (2013) Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.. Biochemistry, 52(51), 9155-9166. Ramly NZ, Rouzheinikov SN, Sedelnikova SE, Baker PJ, Chow YP, Wan KL, Nathan S & Rice DW (2013) Crystallization and preliminary crystallographic analysis of a surface antigen glycoprotein, SAG19, from Eimeria tenella.. Acta Crystallogr Sect F Struct Biol Cryst Commun, 69(Pt 12), 1380-1383. Muench SP, Stec J, Zhou Y, McLeod R, Afanador GA, Prigge ST, McPhillie MJ, Rice DW, Hickman MR, Lee PJ, Leed SE & Auschwitz JM (2013) Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorganic and Medicinal Chemistry Letters. Qureshi MS, Sheikh QI, Hill R, Brown PE, Dickman MJ, Tzokov SB, Rice DW, Gjerde DT & Hornby DP (2013) Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes.. Anal Biochem, 439(1), 47-49. Cheng G, Muench SP, Zhou Y, Mui EJ, Fomovska A, Lai BS, McLeod R, Afanador GA, Prigge ST, Woods S, Roberts CW, Rice DW, Hickman MR, Lee PJ, Leed SE & Auschwitz JM (2013) Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorganic and Medicinal Chemistry Letters.