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个人简介

宗媛,女,中国农业大学农学院教授,博士生导师。1990年10月出生,2013年获西北农林科技大学学士学位,2019年获中国科学院大学博士学位;2019-2021年在中国科学院遗传与发育生物学研究所从事博士后研究。主要研究方向为作物基因组编辑新技术新方法的研发以及小麦精准分子设计育种。建立了多套具有原始创新和广泛适用性的作物精准定点编辑技术体系包括碱基编辑技术、精准多核苷酸删除技术、引导编辑技术等,并利用不同基因编辑工具创制了与产量等重要农艺性状相关的作物新材料。相关研究成果以第一作者(含共同一作)在Science、Nature Biotechnology、Nature Communications等期刊发表。主持国家重点研发计划青年科学家项目、国家自然科学基金面上项目、农业部项目子课题等7项科研项目。2019年入选“未来女科学家计划”,2022年入选科睿唯安“高被引科学家”。 教育经历 2013.09.01-2019.06.30,理学博士学位,中国科学院大学,遗传学 2009.09.01-2013.07.01,农学学士学位,西北农林科技大学,林学 工作经历 2021.06.28,中国农业大学农学院 2019.06.24-2021.06.27,中国科学院遗传与发育生物学研究所

研究领域

植物精准基因组编辑技术的研发和应用;植物合成生物学技术的研究;小麦重要性状的分子设计与育种

近期论文

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Zong Y#, Liu Y#, Xue C#, Li B, Li X, Wang Y, Li J, Liu G, Huang X, Cao X, Gao C (2022) An engineered prime editor with enhanced editing efficiency in plants. Nature Biotechnology, doi: 10.1038/s41587-022-01254-w. Guo M#, Wang Q#, Zong Y#, Nian J, Li H, Li J, Wang T, Gao C, Zuo J (2021) Genetic manipulations of TaARE1 boost nitrogen utilization and grain yield in wheat. Journal of Genetics and Genomics, 48(10):950-953. Lin Q#, Jin S#, Zong Y#, Yu H#, Zhu Z, Liu G, Kou W, Wang Y, Qiu, J.L, Li J, Gao C (2021) High-efficiency prime editing with optimized, paired pegRNAs in plants. Nature Biotechnology, 39(8):923-927. Wang S#, Zong Y#, Lin Q#, Zhang H#, Chai Z, Zhang D, Chen K, Qiu JL, Gao C (2020) Precise, predictable multi-nucleotide deletions in rice and wheat using APOBEC-Cas9. Nature Biotechnology, 8(12):1460-1465. Lin Q#, Zong Y#, Xue C#, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C (2020) Prime genome editing in rice and wheat. Nature Biotechnology, 38(5):582-585. (Recommended in F1000Prime). Li C, Zong Y, Jin S, Zhu H, Lin D, Li S, Qiu JL, Wang Y, Gao C (2020) SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds. Genome Biology, 21(1):141. Li C#, Zhang R#, Meng X#, Chen S, Zong Y, Lu C, Qiu JL, Chen YH, Li J, Gao C (2020) Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors. Nature Biotechnology, 38(7):875-882. 宗媛,高彩霞. 碱基编辑系统研究进展. 遗传, 2019, 41(9): 777-800. Jin S#, Zong Y#, Gao Q#, Zhu Z, Wang Y, Qin P, Liang C, Wang D, Qiu J, Zhang F, Gao C (2019) Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science, 364, 292-295. Zhang R#, Liu J#, Chai Z, Chen S, Bai Y, Zong Y, Chen K, Li J, Jiang L, and Gao C (2019) Generation of herbicide tolerance traits and a new selectable marker in wheat using base editing. Nature Plants, 5, 480-485. Zong Y#, Song Q#, Li C, Jin S, Zhang D, Wang Y, Qiu JL, Gao C (2018) Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A. Nature Biotechnology, 36, 950-953. Li C#, Zong Y#, Wang Y#, Jin S, Zhang D, Song Q, Zhang R, Gao C (2018) Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion. Genome Biology, 19, 59. Zong Y#, Wang Y#, Li C, Zhang R, Chen K, Ran Y, Qiu J, Wang D, Gao C (2017) Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion, Nature Biotechnology, 35, 438. (Recommended in F1000Prime). Wang Y, Zong Y, and Gao C (2017). Targeted mutagenesis in hexaploid bread wheat using the TALEN and CRISPR/Cas systems. Methods in Molecular Biology, 1679, 169-185. Zhang Y#, Liang Z#, Zong Y#, Wang Y, Liu J, Chen K, Qiu J, Gao C (2016) Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nature Communications, 7, 12617. Liang Z, Zong Y, and Gao C (2016). An efficient targeted mutagenesis system using CRISPR/Cas in monocotyledons. Current Protocols in Plant Biology, 1, 329-344. Li J#, Meng X#, Zong Y, Chen K, Zhang H, Liu J, Li J, Gao C (2016) Gene replacements and insertions in rice by intron targeting using CRISPR/Cas9. Nature Plants, 2 (10), 16139.

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