Poole, Robert - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 1996 - present: West Riding Chair of Microbiology, The University of Sheffield 1997 - 2008: Director of Research, Biological Sciences, The University of Sheffield 1994: Fulbright Scholar, Cornell University 1993: Visiting Fellow, Australian National University, Canberra 1990 -1991: Royal Society-Leverhulme Trust Senior Research Fellow (KCL) 1988 -1996: Personal Chair of Microbiology (KCL) 1988: Head of Department, Queen Elizabeth College 1986-1988: Reader in Microbiology, University of London 1984-1985: Royal Society Anglo-Australian Fellow, Australian National University, Canberra 1980-1981: Nuffield Foundation Science Research Fellow, Queen Elizabeth College, London 1984: DSc, University of Wales 1975 -1985: Lecturer, Department of Microbiology, Queen Elizabeth College, London (now King’s College London, KCL) 1973 -1974: Personal SRC Post-doctoral Research Fellowship, Department of Biochemistry, Medical Sciences Institute, The University, Dundee 1967 -1973: BSc (First Class Hons.), Department of Microbiology, University College Cardiff; PhD, Department of Microbiology, University College Cardiff

研究领域

Bacterial physiology, in particular respiration, nitric oxide metabolism and oxidative stress in Escherichia coli. Respiratory pathways, globins and metal transport. Antibiotics and novel antimicrobials, especially CO-releasing molecules.

近期论文

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Shepherd M, Achard MES, Idris A, Totsika M, Phan M-D, Peters KM, Sarkar S, Ribeiro CA, Holyoake LV, Ladakis D, Ulett GC, Sweet MJ, Poole RK, McEwan AG & Schembri MA (2016) The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection. Scientific Reports, 6, 35285-35285. View this article in WRRO Siletsky SA, Rappaport F, Poole RK & Borisov VB (2016) Evidence for Fast Electron Transfer between the High-Spin Haems in Cytochrome bd-I from Escherichia coli. PLOS ONE, 11(5), e0155186-e0155186. View this article in WRRO Cook GM & Poole RK (2016) A bacterial oxidase like no other?. Science, 352(6285), 518-519. Forte E, Borisov VB, Falabella M, Colaço HG, Tinajero-Trejo M, Poole RK, Vicente JB, Sarti P & Giuffrè A (2016) The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth. Scientific Reports, 6, 23788-23788. View this article in WRRO Wareham LK, Begg R, Jesse HE, Van Beilen JWA, Ali S, Svistunenko D, McLean S, Hellingwerf KJ, Sanguinetti G & Poole RK (2016) Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic Resistance. Antioxidants & Redox Signaling. View this article in WRRO Wang J, Vine CE, Balasiny BK, Rizk J, Bradley CL, Tinajero-Trejo M, Poole RK, Bergaust LL, Bakken LR & Cole JA (2016) The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of E scherichia coli against nitrosative stress. Molecular Microbiology, 100(5), 877-892. Tinajero-Trejo M, Rana N, Nagel C, Jesse HE, Smith TW, Wareham LK, Hippler M, Schatzschneider U & Poole RK (2016) Antimicrobial Activity of the Manganese Photoactivated Carbon Monoxide-Releasing Molecule [Mn(CO) 3 (tpa-κ 3 N )] + Against a Pathogenic Escherichia coli that Causes Urinary Infections. Antioxidants & Redox Signaling, 24(14), 765-780. View this article in WRRO Holyoake LV, Hunt S, Sanguinetti G, Cook GM, Howard MJ, Rowe ML, Poole RK & Shepherd M (2016) CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress. Biochemical Journal, 473(6), 693-701. View this article in WRRO