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个人简介

王向峰,男,1978 年生,博士生导师,中国农业大学教授。入选国家级人才计划。2002 年获中国农业大学生物科学学士学位;2007 年获北京大学生物信息学博士学位;2007 到2010 年先后在美国耶鲁大学、哈佛大学完成博士后阶段工作;2010 到2014 年期间,在美国亚利桑那大学,农业与生命科学学院,任终身制助理教授。主要研究方向为利用组学大数据从事玉米杂交育种理论、玉米杂种优势遗传互作机制、玉米基因组驯化、玉米适应性演化机制等方面的工作。应用人工智能与机器学习技术开发玉米智能设计育种决策模型、全基因组选择模型、基因型与环境互作模型;开发玉米育种信息管理系统、育种大数据分析软件;开发玉米多组学数据关联分析算法、种质资源挖掘工具、各类生物信息软件。在Genome Biology、Science Bulletin 、Plant Cell 、PNAS, Trends in Plant Science 、Molecular Plant、Plant Journal 等国际知名期刊发表论文60 余篇。 王向峰课题组招收我校“生物科学”与“生物育种”强基计划学生。辅修过我校信电学院的“数据科学与大数据技术(辅修)”专业的学生,可以被优先考虑进入实验室开展轮转课题,以及作为推免生提前开展硕博阶段的工作。强基计划学生可以在大一下学期考虑辅修“数据科学与大数据技术”相关课程,包括:Linux应用基础与实验、程序设计I与实验、数据库原理与实验、Web技术应用与实验、计算机系统基础与实验、程序设计I与实验、数据结构与算法实验、大数据统计方法与实验、大数据挖掘技术与实验、大数据存储处理技术与实验、大数据分析与可视化技术与实验、人工智能技术与实验。 教育经历 2002.06.01-2007.07.01,博士,北京大学,生物信息学 1998.09.01-2002.07.01,学士,中国农业大学,生物科学 工作经历 2014.06.11,中国农业大学农学院 2008.04.01-2014.06.01,北京市顺义区人才服务中心

研究领域

王向峰教授以解决我国玉米商业化育种体系中的关键技术与重大需求为导向,致力于育种模型、理论与新方法的研究。近5年来,从基于多组学的种质资源挖掘工具、全基因组选择模型、智能设计育种决策模型、基因型与环境互作模型等方法学层面;到玉米杂种优势的利用、表型可塑性的环境响应等理论层面;到开发玉米育种信息管理系统、交互式数字育种平台等应用层面,开展系统性研究工作。代表性成果包括:1)开发多组学数据关联分析软件MODAS,并应用于玉米耐盐基因的挖掘与利用;2)开发基于机器学习算法的作物基因组设计育种工具包CropGBM与基因组优化虚拟设计育种模型GOVS;3)探索玉米杂种优势的利用规律与玉米表型可塑性对环境响应的生物学基础;4)集成自主研究成果,打造为我国种业服务的智能育种技术体系。申请人在国际期刊发表精准育种相关论文10余篇,相关成果为我国商业化育种体系的建设与现代种业的智能化升级提供技术支撑与理论指导。

近期论文

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Qian Wang, Shan Jiang, Tong Li, Zhixu Qiu, Jun Yan, Ran Fu, Chuang Ma, Xiangfeng Wang, Shuqin Jiang, Qian Cheng (2023). G2P Provides an Integrative Environment for Multi-model genomic selection analysis to improve genotype-to-phenotype prediction. Frontiers in Plant Science. Ran Fu, Xiangfeng Wang (2023). Modeling the influence of phenotypic plasticity on maize hybrid performance. Plant Communications. Tong Li, Shan Jiang, Ran Fu, Xiangfeng Wang, Qian Cheng, Shuqin Jiang (2023). IP4GS:Bringing genomic selection analysis to breedersBringing genomic selection analysis to breeders. Plant J. Jun Yan, Xiangfeng Wang (2022). Machine learning bridges omics sciences and plant breeding. Trends in Plant Science. Jun Yan, Xiangfeng Wang (2022). Unsupervised and semi-supervised learning: the next frontier in machine learning for plant systems biology. The Plant Journal. Songyu Liu, Feng Xu, Yuetong Xu, Qian Wang, Jun Yan, Jinyu Wang, Xianbing Wang, Xiangfeng Wang (2022). MODAS: exploring maize germplasm with multi-omics data association studies. Science Bulletin. Matthew McGowan, Jiabo Wang, Haixiao Dong, Xiaolei Liu, Yi Jia, Xiangfeng Wang, Hiroyoshi Iwata, Yutao Li, Alexander E. Lipka, Zhiwu Zhang (2021). Ideas in Genomic Selection with the Potential to Transform Plant Molecular Breeding: A Review. Plant Breeding Reviews. Qian Cheng, Shuqing Jiang, Feng Xu, Qian Wang, Yingjie Xiao, Ruyang Zhang, Jiuran Zhao, Jianbing Yan, Chuang Ma, Xiangfeng Wang (2021). Genome optimization via virtual simulation to accelerate maize hybrid breeding. Briefings in Bioinformatics. Yuetong Xu, John D. Laurie, Xiangfeng Wang (2021). CropGBM: An Ultra-Efficient Machine Learning Toolbox for Genomic Selection-Assisted Breeding in Crops. Springer Protocols Handbooks. Jun Yan, Yuetong Xu, Qian Cheng, Shuqin Jiang, Qian Wang, Yingjie Xiao, Chuang Ma, Jianbing Yan, Xiangfeng Wang (2021). LightGBM: accelerated genomically designed crop breeding through ensemble learning. Genome Biol. Fengchao Cui, Geli Taier, Manli Li, Xiaoxia Dai, Nan Hang, Xunzhong Zhang, Xiangfeng Wang, Kehua Wang (2021). The genome of the warm-season turfgrass African bermudagrass (Cynodon transvaalensis). Hortic Res. Yingjie Xiao, Shuqin Jiang, Qian Cheng, Xiaqing Wang, Jun Yan, Ruyang Zhang, Feng Qiao, Chuang Ma, Jingyun Luo, Wenqiang Li, Haijun Liu, Wenyu Yang, Wenhao Song, Yijiang Meng, Marilyn L. Warburton, Jiuran Zhao, Xiangfeng Wang, Jianbing Yan (2021). The genetic mechanism of heterosis utilization in maize improvement. Genome Biol. Xiaoyan Liang, Songyu Liu, Tao Wang, Fenrong Li, Jinkui Cheng, Jinsheng Lai, Feng Qin, Zhen Li, Xiangfeng Wang, Caifu Jiang (2021). Metabolomics-driven gene mining and genetic improvement of tolerance to salt-induced osmotic stress in maize. New Phytol. Chunming Yang, Jun Yan, Shuqin Jiang, Xia Li, Haowei Min, Xiangfeng Wang, Dongyun Hao (2021). Resequencing 250 soybean accessions: new insights into genes associated with agronomic traits and genetic networks. Genomics, Proteomics & Bioinformatics. Shi-Jian Zhang, Lei Liu, Ruolin Yang, Xiangfeng Wang (2020). Genome Size Evolution Mediated by Gypsy Retrotransposons in Brassicaceae. Genomics, Proteomics & Bioinformatics. Jun Yan, Dong Zou, Chen Li, Zhang Zhang, Shuhui Song, Xiangfeng Wang (2020). SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice. Genomics, Proteomics & Bioinformatics. Zhipeng Zhou, Guoliang Li, Siyu Tan, Dongdong Li, Thea Mi Wei?, Xiangfeng Wang, Shaojiang Chen, Tobias Würschum, Wenxin Liu (2020). A QTL atlas for grain yield and its component traits in maize ( Zea mays ). Plant Breed. Huan Zhang, Qian Zhang, Hong Zhai, Shaopei Gao, Li Yang, Zhen Wang, Yuetong Xu, Jinxi Huo, Zhitong Ren, Ning Zhao, Xiangfeng Wang, Jigang Li, Qingchang Liu, Shaozhen He (2020). IbBBX24 Promotes the Jasmonic Acid Pathway and Enhances Fusarium Wilt Resistance in Sweet Potato. Plant Cell. Zechuan Lin, Peng Qin, Xuanwen Zhang, Chenjian Fu, Hanchao Deng, Xingxue Fu, Zhen Huang, Shuqin Jiang, Chen Li, Xiaoyan Tang, Xiangfeng Wang, Guangming He, Yuanzhu Yang, Hang He, Xing Wang Deng (2020). Divergent selection and genetic introgression shape the genome landscape of heterosis in hybrid rice. Proc Natl Acad Sci USA. Hong Li, Shuqin Jiang, Chen Li, Lei Liu, Zechuan Lin, Hang He, Xing Wang Deng, Ziding Zhang, Xiangfeng Wang (2019). The hybrid protein interactome contributes to rice heterosis as epistatic effects. Plant J. Shuqin Jiang, Qian Cheng, Jun Yan, Ran Fu, Xiangfeng Wang (2019). Genome optimization for improvement of maize breeding. Theor Appl Genet. Peng Liang, Songyu Liu, Feng Xu, Shuqin Jiang, Jun Yan, Qiguang He, Wenbo Liu, Chunhua Lin, Fucong Zheng, Xiangfeng Wang, Weiguo Miao (2019). Corrigendum: Powdery Mildews Are Characterized by Contracted Carbohydrate Metabolism and Diverse Effectors to Adapt to Obligate Biotrophic Lifestyle. Front. Microbiol.. Peng Liang, Songyu Liu, Feng Xu, Shuqin Jiang, Jun Yan, Qiguang He, Wenbo Liu, Chunhua Lin, Fucong Zheng, Xiangfeng Wang, Weiguo Miao (2018). Powdery Mildews Are Characterized by Contracted Carbohydrate Metabolism and Diverse Effectors to Adapt to Obligate Biotrophic Lifestyle. Front. Microbiol.. Shi-Jian Zhang, Peiqi Meng, Jieni Zhang, Peizeng Jia, Jiuxiang Lin, Xiangfeng Wang, Feng Chen, Xiaoxing Wei (2018). Machine Learning Models for Genetic Risk Assessment of Infants with Non-syndromic Orofacial Cleft. Genomics, Proteomics & Bioinformatics. Junpeng Zhan, Guosheng Li, Choong-Hwan Ryu, Chuang Ma, Shanshan Zhang, Alan Lloyd, Brenda G. Hunter, Brian A. Larkins, Gary N. Drews, Xiangfeng Wang, Ramin Yadegari (2018). Opaque-2 Regulates a Complex Gene Network Associated with Cell Differentiation and Storage Functions of Maize Endosperm. Plant Cell. Weilong Guo, Ping Zhu, Matteo Pellegrini, Michael Q Zhang, Xiangfeng Wang, Zhongfu Ni (2017). CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data. Bioinformatics. Yuange Wang, Haopeng Yu, Caihuan Tian, Muhammad Sajjad, Caixia Gao, Yiping Tong, Xiangfeng Wang, Yuling Jiao (2017). Transcriptome Association Identifies Regulators of Wheat Spike Architecture. Plant Physiol.. Shi-Jian Zhang, Chenqu Wang, Shouyu Yan, Aisi Fu, Xuke Luan, Yumei Li, Qing Sunny Shen, Xiaoming Zhong, Jia-Yu Chen, Xiangfeng Wang, Bertrand Chin-Ming Tan, Aibin He, Chuan-Yun Li (2017). Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events. Molecular Biology and Evolution. Huan Zhang, Qian Zhang, Hong Zhai, Yan Li, Xiangfeng Wang, Qingchang Liu, Shaozhen He (2017). Transcript profile analysis reveals important roles of jasmonic acid signalling pathway in the response of sweet potato to salt stress. Sci Rep. Jun Yan, Shuwei Lv, Min Hu, Zhaoxu Gao, Hang He, Qingwei Ma, Xing~Wang Deng, Zuofeng Zhu, Xiangfeng Wang (2016). Single-Molecule Sequencing Assists Genome Assembly Improvement and Structural Variation Inference. Molecular Plant. Xuanli Yao, Herbert N. Arst, Xiangfeng Wang, Xin Xiang (2015). Discovery of a vezatin-like protein for dynein-mediated early endosome transport. MBoC. Mingming Xin, Guanghui Yang, Yingyin Yao, Huiru Peng, Zhaorong Hu, Qixin Sun, Xiangfeng Wang, Zhongfu Ni (2015). Temporal small RNA transcriptome profiling unraveled partitioned miRNA expression in developing maize endosperms between reciprocal crosses. Front. Plant Sci.. Junpeng Zhan, Dhiraj Thakare, Chuang Ma, Alan Lloyd, Neesha M. Nixon, Angela M. Arakaki, William J. Burnett, Kyle O. Logan, Dongfang Wang, Xiangfeng Wang, Gary N. Drews, Ramin Yadegari (2015). RNA Sequencing of Laser-Capture Microdissected Compartments of the Maize Kernel Identifies Regulatory Modules Associated with Endosperm Cell Differentiation. Plant Cell. Chuang Ma, Hao Helen Zhang, Xiangfeng Wang (2014). Machine learning for Big Data analytics in plants. Trends in Plant Science. Mingming Xin, Ruolin Yang, Yingyin Yao, Chuang Ma, Huiru Peng, Qixin Sun, Xiangfeng Wang, Zhongfu Ni (2014). Dynamic parent-of-origin effects on small interfering RNA expression in the developing maize endosperm. BMC Plant Biol. G. Li, D. Wang, R. Yang, K. Logan, H. Chen, S. Zhang, M. I. Skaggs, A. Lloyd, W. J. Burnett, J. D. Laurie, B. G. Hunter, J. M. Dannenhoffer, B. A. Larkins, G. N. Drews, X. Wang, R. Yadegari (2014). Temporal patterns of gene expression in developing maize endosperm identified through transcriptome sequencing. Proceedings of the National Academy of Sciences. Chuang Ma, Mingming Xin, Kenneth A. Feldmann, Xiangfeng Wang (2014). Machine Learning–Based Differential Network Analysis: A Study of Stress-Responsive Transcriptomes in Arabidopsis. Plant Cell. Yuliang Zhang, Naitong Yu, Qixing Huang, Guohua Yin, Anping Guo, Xiangfeng Wang, Zhongguo Xiong, Zhixin Liu (2014). Complete genome of Hainan papaya ringspot virus using small RNA deep sequencing. Virus Genes. Mingming Xin, Ruolin Yang, Guosheng Li, Hao Chen, John Laurie, Chuang Ma, Dongfang Wang, Yingyin Yao, Brian A. Larkins, Qixin Sun, Ramin Yadegari, Xiangfeng Wang, Zhongfu Ni (2013). Dynamic Expression of Imprinted Genes Associates with Maternally Controlled Nutrient Allocation during Maize Endosperm Development. Plant Cell. Xiaoxing Wei, Xiangfeng Wang (2013). A Computational Workflow to Identify Allele-specific Expression and Epigenetic Modification in Maize. Genomics, Proteomics & Bioinformatics. Hao Chen, Xiangfeng Wang (2013). CrusView: A Java-Based Visualization Platform for Comparative Genomics Analyses in Brassicaceae Species. Plant Physiol.. Ruolin Yang, David E. Jarvis, Hao Chen, Mark A. Beilstein, Jane Grimwood, Jerry Jenkins, ShengQiang Shu, Simon Prochnik, Mingming Xin, Chuang Ma, Jeremy Schmutz, Rod A. Wing, Thomas Mitchell-Olds, Karen S. Schumaker, Xiangfeng Wang (2013). The Reference Genome of the Halophytic Plant Eutrema salsugineum. Front. Plant Sci.. Ruolin Yang, Xiangfeng Wang (2013). Organ Evolution in Angiosperms Driven by Correlated Divergences of Gene Sequences and Expression Patterns. The Plant Cell. C. Ma, H. Chen, M. Xin, R. Yang, X. Wang (2012). KGBassembler: a karyotype-based genome assembler for Brassicaceae species. Bioinformatics. Mingming Xin, Xiangfeng Wang, Huiru Peng, Yingyin Yao, Chaojie Xie, Yao Han, Zhongfu Ni, Qixin Sun (2012). Transcriptome Comparison of Susceptible and Resistant Wheat in Response to Powdery Mildew Infection. Genomics, Proteomics & Bioinformatics. Xiangfeng Wang, John D. Laurie, Tao Liu, Jacqueline Wentz, X. Shirley Liu (2011). Computational dissection of Arabidopsis smRNAome leads to discovery of novel microRNAs and short interfering RNAs associated with transcription start sites. Genomics. Xiangfeng Wang, X. Shirley Liu (2011). Systematic Curation of miRBase Annotation Using Integrated Small RNA High-Throughput Sequencing Data for C. elegans and Drosophila. Front. Gene.. Huiyong Zhang, Hang He, Xuncheng Wang, Xiangfeng Wang, Xiaozeng Yang, Lei Li, Xing W. Deng (2010). Genome-wide mapping of the HY5-mediated genenetworks in Arabidopsis that involve both transcriptional and post-transcriptional regulation. The Plant Journal. Hang He, Huiyong Zhang, Xiangfeng Wang, Nicholas Wu, Xiaozeng Yang, Runsheng Chen, Yi Li, Xing Wang Deng, Lei Li (2010). Development of a versatile, target-oriented tiling microarray assay for measuring allele-specific gene expression. Genomics. Guangming He, Xiaopeng Zhu, Axel A. Elling, Liangbi Chen, Xiangfeng Wang, Lan Guo, Manzhong Liang, Hang He, Huiyong Zhang, Fangfang Chen, Yijun Qi, Runsheng Chen, Xing Wang Deng (2010). Global Epigenetic and Transcriptional Trends among Two Rice Subspecies and Their Reciprocal Hybrids. The Plant Cell. Junli Zhou, Xiangfeng Wang, Kun He, Jean-Benoit F. Charron, Axel A. Elling, Xing Wang Deng (2010). Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression. Plant Mol Biol. Xiangfeng Wang, Axel A. Elling, Xueyong Li, Ning Li, Zhiyu Peng, Guangming He, Hui Sun, Yijun Qi, X. Shirley Liu, Xing Wang Deng (2009). Genome-Wide and Organ-Specific Landscapes of Epigenetic Modifications and Their Relationships to mRNA and Small RNA Transcriptomes in Maize. The Plant Cell. Xiangfeng Wang, Zhihui Yu, Xiaozeng Yang, Xing Wang Deng, Lei Li (2009). Transcriptionally active gene fragments derived from potentially fast-evolving donor genes in the rice genome. Bioinformatics. Zhi-Yu Peng, Huiyong Zhang, Tingting Liu, Katherine M. Dzikiewicz, Songgang Li, Xiangfeng Wang, Guocheng Hu, Zhengge Zhu, Xinghua Wei, Qi-Hui Zhu, Zongxiu Sun, Song Ge, Ligeng Ma, Lei Li, Xing Wang Deng (2009). Characterization of the genome expression trends in the heading-stage panicle of six rice lineages. Genomics. Ben-Liang Yin, Lan Guo, Dong-Fen Zhang, William Terzaghi, Xiang-Feng Wang, Ting-Ting Liu, Hang He, Zhu-Kuan Cheng, Xing Wang Deng (2008). Integration of Cytological Features with Molecular and Epigenetic Properties of Rice Chromosome 4. Molecular Plant. Hui-Yong Zhang, Hang He, Liang-Bi Chen, Lei Li, Man-Zhong Liang, Xiang-Feng Wang, Xi-Gang Liu, Guang-Ming He, Run-Sheng Chen, Li-Geng Ma, Xing Wang Deng (2008). A Genome-Wide Transcription Analysis Reveals a Close Correlation of Promoter INDEL Polymorphism and Heterotic Gene Expression in Rice Hybrids. Molecular Plant. Xueyong Li, Xiangfeng Wang, Kun He, Yeqin Ma, Ning Su, Hang He, Viktor Stolc, Waraporn Tongprasit, Weiwei Jin, Jiming Jiang, William Terzaghi, Songgang Li, Xing Wang Deng (2008). High-Resolution Mapping of Epigenetic Modifications of the Rice Genome Uncovers Interplay between DNA Methylation, Histone Methylation, and Gene Expression. The Plant Cell. Lei Li, Hang He, Juan Zhang, Xiangfeng Wang, Sulan Bai, Viktor Stolc, Waraporn Tongprasit, Nevin D Young, Oliver Yu, Xing Wang Deng (2008). Transcriptional analysis of highly syntenic regions between Medicago truncatula and Glycine max using tiling microarrays. Genome Biol. Lei Li, Xiangfeng Wang, Rajkumar Sasidharan, Viktor Stolc, Wei Deng, Hang He, Jan Korbel, Xuewei Chen, Waraporn Tongprasit, Pamela Ronald, Runsheng Chen, Mark Gerstein, Xing Wang Deng (2007). Global Identification and Characterization of Transcriptionally Active Regions in the Rice Genome. PLoS ONE. Junli Zhou, Xiangfeng Wang, Yuling Jiao, Yonghua Qin, Xigang Liu, Kun He, Chen Chen, Ligeng Ma, Jian Wang, Lizhong Xiong, Qifa Zhang, Liumin Fan, Xing Wang Deng (2007). Global genome expression analysis of rice in response to drought and high-salinity stresses in shoot, flag leaf, and panicle. Plant Mol Biol. X. Wang, H. He, L. Li, R. Chen, X. W. Deng, S. Li (2006). NMPP: a user-customized NimbleGen microarray data processing pipeline. Bioinformatics. Lei Li, Xiangfeng Wang, Viktor Stolc, Xueyong Li, Dongfen Zhang, Ning Su, Waraporn Tongprasit, Songgang Li, Zhukuan Cheng, Jun Wang, Xing Wang Deng (2005). Genome-wide transcription analyses in rice using tiling microarrays. Nat Genet. Viktor Stolc, Lei Li, Xiangfeng Wang, Xueyong Li, Ning Su, Waraporn Tongprasit, Bin Han, Yongbiao Xue, Jiayang Li, Michael Snyder, Mark Gerstein, Jun Wang, Xing Wang Deng (2005). A Pilot Study of Transcription Unit Analysis in Rice Using Oligonucleotide Tiling-path Microarray. Plant Mol Biol. L. Ma (2005). A microarray analysis of the rice transcriptome and its comparison to Arabidopsis. Genome Research. Yuling Jiao, Peixin Jia, Xiangfeng Wang, Ning Su, Shuliang Yu, Dongfen Zhang, Ligeng Ma, Qi Feng, Zhaoqing Jin, Lei Li, Yongbiao Xue, Zhukuan Cheng, Hongyu Zhao, Bin Han, Xing Wang Deng (2005). A Tiling Microarray Expression Analysis of Rice Chromosome 4 Suggests a Chromosome-Level Regulation of Transcription. The Plant Cell. Lei Li, Xiangfeng Wang, Mian Xia, Viktor Stolc, Ning Su, Zhiyu Peng, Songgang Li, Jun Wang, Xiping Wang, Xing Deng (2005). Tiling microarray analysis of rice chromosome 10 to identify the transcriptome and relate its expression to chromosomal architecture. Genome Biol.

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