Hwang, Ling Chin - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2015 - present: Lecturer, Dept. of Molecular Biology and Microbiology, University of Sheffield, UK 2010 - 2015: Postdoctoral Fellow, National Institutes of Health, Bethesda, MD, USA 2006 - 2009: Postdoctoral Researcher, Dept. of Physics, University of Oxford, UK 2002 - 2006: PhD., Chemistry, National University of Singapore 1995 - 2000: BSc. (Honors), Chemistry, National University of Singapore

研究领域

Multidisciplinary techniques such as single-molecule imaging, synthetic biology, biochemistry and microfluidics to study the molecular mechanisms of spatial organization in bacteria, such as cell division and chromosome segregation.

近期论文

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Vecchiarelli AG, Li M, Mizuuchi M, Hwang LC, Seol Y, Neuman KC & Mizuuchi K (2016) Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD. Proceedings of the National Academy of Sciences, 113(11), E1479-E1488. Robb NC, Cordes T, Hwang LC, Gryte K, Duchi D, Craggs TD, Santoso Y, Weiss S, Ebright RH & Kapanidis AN (2013) The Transcription Bubble of the RNA Polymerase–Promoter Open Complex Exhibits Conformational Heterogeneity and Millisecond-Scale Dynamics: Implications for Transcription Start-Site Selection. Journal of Molecular Biology, 425(5), 875-885. Vecchiarelli AG, Hwang LC & Mizuuchi K (2013) Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism. Proceedings of the National Academy of Sciences, 110(15), E1390-E1397. Hwang LC, Vecchiarelli AG, Han Y-W, Mizuuchi M, Harada Y, Funnell BE & Mizuuchi K (2013) ParA-mediated plasmid partition driven by protein pattern self-organization. The EMBO Journal, 32(9), 1238-1249. Cordes T, Santoso Y, Tomescu AI, Gryte K, Hwang LC, Camará B, Wigneshweraraj S & Kapanidis AN (2010) Sensing DNA Opening in Transcription Using Quenchable Förster Resonance Energy Transfer. Biochemistry, 49(43), 9171-9180. Heilemann M, Hwang LC, Lymperopoulos K & Kapanidis AN (2009) Single-molecule FRET analysis of protein-DNA complexes. Methods in Molecular Biology, 543, 503-521. Hwang LC & Wohland T (2007) Recent Advances in Fluorescence Cross-correlation Spectroscopy. Cell Biochemistry and Biophysics, 49(1), 1-13. Liu P, Sudhaharan T, Koh RML, Hwang LC, Ahmed S, Maruyama IN & Wohland T (2007) Investigation of the Dimerization of Proteins from the Epidermal Growth Factor Receptor Family by Single Wavelength Fluorescence Cross-Correlation Spectroscopy. Biophysical Journal, 93(2), 684-698.