Hu, Bin - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2015 - present: University Research Fellow, Department of Molecular Biology and Biotechnology, University of Sheffield, UK 2007 - 2014: Postdoctoral research associate, University of Oxford, UK 2006 - 2007: Postdoctoral research associate, King’s College London, UK 2002 - 2005: PhD, King’s College London, UK

研究领域

Eukaryotic cell cycle regulation, with particular focus on protein-DNA interactions in chromosomes and how cells incorporate environmental signals into cell proliferation and how cells make a decision on growth or death upon environmental stress.

近期论文

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Beckouët F, Srinivasan M, Roig MB, Chan K-L, Scheinost JC, Batty P, Hu B, Petela N, Gligoris T, Smith AC, Strmecki L, Rowland BD & Nasmyth K (2016) Releasing Activity Disengages Cohesin’s Smc3/Scc1 Interface in a Process Blocked by Acetylation. Molecular Cell, 61(4), 563-574. View this article in WRRO Chan K-L, Roig MB, Hu B, Beckouët F, Metson J & Nasmyth K (2012) Cohesin’s DNA Exit Gate Is Distinct from Its Entrance Gate and Is Regulated by Acetylation. Cell, 150(5), 961-974. Hu B, Itoh T, Mishra A, Katoh Y, Chan K-L, Upcher W, Godlee C, Roig MB, Shirahige K & Nasmyth K (2011) ATP Hydrolysis Is Required for Relocating Cohesin from Sites Occupied by Its Scc2/4 Loading Complex. Current Biology, 21(1), 12-24. Mishra A, Hu B, Kurze A, Beckouët F, Farcas A-M, Dixon SE, Katou Y, Khalid S, Shirahige K & Nasmyth K (2010) Both Interaction Surfaces within Cohesin's Hinge Domain Are Essential for Its Stable Chromosomal Association. Current Biology, 20(4), 279-289. Beckouët F, Hu B, Roig MB, Sutani T, Komata M, Uluocak P, Katis VL, Shirahige K & Nasmyth K (2010) An Smc3 Acetylation Cycle Is Essential for Establishment of Sister Chromatid Cohesion. Molecular Cell, 39(5), 689-699. Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C & Pearl LH (2008) Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37. Molecular Cell, 31(6), 886-895. Liao C, Hu B, Arno C & Panaretou B (2007) Genomic screening in vivo reveals the role played by vacuolar H+ ATPase and cytosolic acidification in sensitivity to DNA-damaging agents such as cisplatin. Mol Pharmacol, 71(2), 416-425. Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall JM, Mollapour M, Soti C & Piper PW (2007) Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.. The FEBS Journal(17), 4453-4463.