Hornby, David - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2015 - present: Professor of Biochemistry, Dept. Molecular Biology and Biotechnology 2013 - 2015: Director of Innovation, Liverpool Life Sciences UTC 2012: Professor of Biochemistry Department of Molecular Biology and Biotechnology (on sabbatical leave at the Liverpool School of Tropical Medicine) 2007 - 2012: Head of the Department of Molecular Biology and Biotechnology 2008 - 2011: Director of Enterprise in Life Sciences 1999 - 2007: Professor of Biochemistry Department of Molecular Biology and Biotechnology 1999 - 2002: Director of the Transgenomic Research Laboratory 1998 - 1999: Reader Department of Molecular Biology and Biotechnology 1994 - 1998: Senior Lecturer Department of Molecular Biology and Biotechnology 1992 - 1993: Visiting Scientist Department Molecular Biology The Scripps Research Institute California 1990 - 1994: Lecturer Department of Molecular Biology and Biotechnology 1990: EMBO fellowship Gene Expression Program EMBL, Heidelberg 1986 - 1990: Lecturer Department of Biochemistry 1985 - 1986: Postdoctoral research associate Biozentrum der Universitat Basel, Switzerland 1984 - 1985: Postdoctoral research associate Departments of Biochemistry, Sheffield and Genetics, Leeds 1980 - 1984: PhD (Biochemistry) University of Sheffield 1977 - 1980: BSc Hons (Biochemistry) University of Sheffield

研究领域

Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.

近期论文

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Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ & Dickman MJ (2015) Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA, 21(3), 347-359. View this article in WRRO Qureshi MS, Sheikh QI, Hill R, Brown PE, Dickman MJ, Tzokov SB, Rice DW, Gjerde DT & Hornby DP (2013) Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes.. Anal Biochem, 439(1), 47-49. Xu W, Liu L, Brown NJ, Christian S & Hornby D (2012) Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice.. Molecules, 17(1), 796-808. Xu W, Liu L & Hornby D (2012) c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.. Molecules, 17(10), 12086-12101. Waghmare SP, Pousinis P, Hornby DP & Dickman MJ (2009) Studying the mechanism of RNA separations using RNA chromatography and its application in the analysis of ribosomal RNA and RNA:RNA interactions.. J Chromatogr A, 1216(9), 1377-1382. Hanna C, Gjerde D, Nguyen L, Dickman M, Brown P & Hornby D (2006) Micro-scale open-tube capillary separations of functional proteins. ANAL BIOCHEM, 350(1), 128-137. Dickman MJ & Hornby DP (2006) Enrichment and analysis of RNA centered on ion pair reverse phase methodology.. RNA, 12(4), 691-696. Dickman MJ, Sedelnikova SE, Rafferty JB & Hornby DP (2004) Rapid analysis of protein-nucleic acid complexes using MALDI TOF mass spectrometry and ion pair reverse phase liquid chromatography.. J Biochem Biophys Methods, 58(1), 39-48. Brown PE, Hornby DP & Dickman MJ (2004) Identification of nuclear protein complexes using open tube capillary chromatography. AIChE Annual Meeting, Conference Proceedings, 1917. Harris VH, Smith CL, Cummins WJ, Hamilton AL, Hornby DP & Williams DM (2003) Recognition of base-pairing by DNA polymerases during nucleotide incorporation: the properties of the mutagenic nucleotide dPTP alphaS.. Org Biomol Chem, 1(12), 2070-2074.