Hodgson, Adam - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2014 - present: Human and Molecular Genetics MSc Coordinator, University Lecturer, MBB 2013 - 2014: Post Doctoral Researcher - Surface-enhanced Raman spectroscopy, development of nanotechnology for diagnostics - The University of Sheffield MBB/CHEM 2013: Duty Scientist Oncology Cytogenetics - Sheffield Children’s Hospital NHS Foundation Trust, SDGS 2012: PGCert Clinical Cytogenetics - Sheffield Children’s Hospital NHS Foundation Trust, SDGS 2010: PhD - Meiotic Recombination - The University of Sheffield, MBB 2005: 1st - BSc (Hons) Genetics The University of Sheffield

研究领域

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Course Coordinator – Human and Molecular Genetics MSc DNA repair is critical to cell survival and the maintenance of genome stability in most organisms. One important class of damage is the DNA double-strand break (DSB) that can arise from various genotoxic sources as well as part of developmental pathways that involve creating genetic change. During meiosis DSBs are deliberately induced and repaired, this process is vital for fertility in most organisms. The DNA repair mechanism utilised in this process, homologous recombination (HR), is highly complicated and involves many proteins. My PhD research focused on resection, which is one of the initial phases of HR. To improve our understanding of this important field of research I quantified the DNA intermediates generated by this mechanism and further characterised the proteins involved. Later, as a Clinical Scientist, my main area of interest was the genetic diagnosis of haematological malignancies, in particular leukaemia classification and prognosis using cytogenetic diagnostic methods. Then as a postdoctoral researcher my research aimed to develop a highly sensitive label-free DNA detection system using gold nanotechnology and surface plasmon resonance. In my current role as a University Teacher I hope to draw on my academic and clinical expertise to educate students in human genetics and genetic diagnosis.