Hettema, Ewald - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2014 - present: Reader in Molecular Cell Biology, Dept. Molecular Biology and Biotechnology, University of Sheffield 2008 - 2014: Wellcome Trust Senior Research Fellow in Basic Biomedical Science at University of Sheffield 2004 - 2008: Wellcome Trust Career Development Fellow at University of Sheffield 2000 - 2004: Post doc MRC LMB, Cambridge 1998 - 2000: Post doc University of Amsterdam 1998: PhD University of Amsterdam

研究领域

Use of the model yeast Saccharomyces cerevisiae and the fruitfly Drosophila melanogaster to study eukaryotic peroxisomes. Particular focus on the role of peroxisome membrane proteins in the biogenesis, maturation, segregation and breakdown of peroxisomes.

近期论文

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Motley AM, Galvin PC, Ekal L, Nuttall JM & Hettema EH (2015) Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis. The Journal of Cell Biology, 211(5), 1041-1056. View this article in WRRO Kim PK & Hettema EH (2015) Multiple Pathways for Protein Transport to Peroxisomes. Journal of Molecular Biology, 427(6), 1176-1190. View this article in WRRO Hettema EH, Erdmann R, van der Klei I & Veenhuis M (2014) Evolving models for peroxisome biogenesis. Current Opinion in Cell Biology, 29(1), 25-30. View this article in WRRO Nuttall JM, Motley AM & Hettema EH (2014) Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae.. Autophagy, 10(5), 835-845. View this article in WRRO Nuttall J, Motley A & Hettema E (2013) Pexophagy is activated in a subset of peroxisome assembly mutants. MOLECULAR BIOLOGY OF THE CELL, 24. Fakieh MH, Drake PJ, Lacey J, Munck JM, Motley AM & Hettema EH (2013) Intra-ER sorting of the peroxisomal membrane protein Pex3 relies on its luminal domain.. Biol Open, 2(8), 829-837. View this article in WRRO Motley AM, Nuttall JM & Hettema EH (2012) Atg36: the Saccharomyces cerevisiae receptor for pexophagy.. Autophagy, 8(11), 1680-1681. Nuttall JM, Hettema EH & Watts DJ (2012) Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum.. Biochem J, 447(3), 353-361. View this article in WRRO Motley AM, Nuttall JM & Hettema EH (2012) Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae.. EMBO J, 31(13), 2852-2868. Nuttall JM, Motley A & Hettema EH (2011) Peroxisome biogenesis: Recent advances. Current Opinion in Cell Biology, 23(4), 421-426.