李依璇 - 中国农业大学 - 营养与健康系（营养与健康研究院）

个人简介

2021.03-至今：中国农业大学，副教授（优秀人才引进） 2018.07-2021.03：中国农业大学，北京食品营养与人类健康高精尖创新中心，博士后 2013.09-2018.06：中国农业大学，工学博士 2009.09-2013.07：中国农业大学，工学学士课题项目校企合作项目“乳源蛋白及组合物肠道免疫功效研究“，105.2万，主持揭榜挂帅项目“益生菌产业化关键技术研究与应用“，300万，主持国家自然科学重点基金-直接超高温灭菌乳蛋白复合体的结构表征及“老化凝胶”形成机制，300万，课题骨干中国工程院一般战略咨询项目“食品安全营养健康学科建设战略研究”，59.66万，课题骨干中国工程院重大战略咨询项目“食品营养与健康战略研究”，300万，课题骨干

研究领域

营养素的功能活性及作用机制功能食品的开发与功能评价食源性危害因子的作用机理

近期论文

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Yixuan Li, Jiaqiang Huang, Jingxuan Wang, Mengjuan Ma, Yao Lu, Ran Wang, Huiyuan Guo Lactoferrin is a potential activator of the vitamin D receptor in its regulation of osteogenic activities in C57BL/6J mice and MC3T3-E1 cells Journal of Nutrition, 2021 Yixuan Li, Jingxuan Wang, Fazheng Ren, Wei Zhang, Hao Zhang, Liang Zhao, Ming Zhang, Wei Cui, Xiaobin Wang, and Huiyuan Guo* Lactoferrin Promotes Osteogenesis through TGF-β Receptor II Binding in Osteoblasts and Activation of Canonical TGF-β Signaling in MC3T3-E1 Cells and C57BL/6J Mice. Journal of Nutrition, 2018, 148(8), 1285-1292 Yixuan Li, Wei Zhang, Fazheng Ren, and Huiyuan Guo* Activation of TGF-_ Canonical and Noncanonical Signaling in Bovine Lactoferrin-Induced Osteogenic Activity of C3H10T1/2 Mesenchymal Stem Cells. International Journal of Molecular Science, 2019, 20,2880 Chenyuan Wang, Ming Zhang, Huiyuan Guo, Jingyu Yan, Lingli Chen, Wendi Teng, Fazheng Ren, Yiran Li, Xifan Wang, Jie Luo, and Yixuan Li* Human Milk Oligosaccharides Activate Epidermal Growth Factor Receptor and Protect Against Hypoxia-Induced Injuries in the Mouse Intestinal Epithelium and Caco2 Cells. Journal of Nutrition, 2019, 10.1093 Ning Liu, Gang Feng, Xiaoying Zhang, Qingjuan Hu, Shiqiang Sun, Jiaqi Sun, Yanan Sun, Ran Wang, Yan Zhang, Pengjie Wang and Yixuan Li* The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease. Frontiers in Nutrition, 2021, 8, 759507 Guoping Zhao, Xiaoyu Wang, Jinwang Li, Ran Wang, Fazheng Ren, Guofang Pang, Yixuan Li*. Imidacloprid increases intestinal permeability by disrupting tight junctions. 2021, 222, 112476 Guoping Zhao, Jinwang Li, Fangwei Yang, Xiaoyu Wang, Fazheng Ren, Guofang Pang, Yixuan Li*. Nitrogen contaminants damage on intestinal epithelial tight junctions: a review. Environmental Chemistry Letters, 2021, 19 (6), 4549-4561 Haina Gao, Fazheng Ren, Pengcheng Wen, Xiaoli Xie, Ran Wang, Zhennai Yang*, Yixuan Li*. Yak milk-derived exosomal miRNA regulate intestinal epithelial cells on proliferation in hypoxic environment. Journal of Dairy Science, 2021, 104(2), 1291-1303 Jinwang Li, Bing Fang, Fazheng Rena, Hanzhu Xing, Guoping Zhao, Xuefeng Yin, Guofang Pang, Yixuan Li*. TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway. Science of the Total Environment, 2020, 10.1016 Fang-Wei Yang, Guo-Ping Zhao, Fa-Zheng Ren, Guo-Fang Pang*, Yi-Xuan Li*. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches. Environment International, 2019, 135 Ran Wang*, Jian Sun , Guihua Li, Ming Zhang, Tianjiao Niu, Xiaohong Kang, Hongfeng Zhao, Jianguo Chen, Erna Sun, Yixuan Li*. Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota. Beneficial Microbes, 2020: 1-12. Yanxiong Huo, Xuhong Lu, Xiaoyu Wang, Xifan Wang, Lingli Chen, Huiyuan Guo, Ming Zhang*, Yixuan Li*. Bifidobacterium animalis subsp. Lactis A6 Alleviates Obesity Associated with Promoting Mitochondrial Biogenesis and Function of Adipose Tissue in Mice. Molecules, 2020. 25(7). Jingxuan Wang, Yixuan Li, Liang Zhao, Fazheng Ren, Huiyuan Guo*. Lactoferrin stimulates the expression of vitamin D receptor in vitamin D deficient mice. Journal of Functional Foods. 2019: 48-56. 李依璇，罗洁，任发政，郭慧媛. 我国乳制品工业的发展历程. 中国奶牛，2019.10 张一帆，逄金柱，米丽娟，李依璇*. 添加α-乳白蛋白和色氨酸的婴儿配方奶粉对新生大鼠脑发育的影响, 中国食品学报，2022.3