个人简介
2022.10-至今：中国农业大学，优秀人才引进，副教授
2019.01-2022.09：中国科学院生物物理研究所，副研究员
2015.05-2018.12：中国科学院生物物理研究所，助理研究员
2009.09-2015.01：中国农业大学，动物生理学，理学博士
2005.09-2009.06：河北师范大学，生命科学学院，生物科学，理学学士
课题项目
国家乳业技术创新中心创新能力建设重点项目，2024.06-2025.12, 70万，主持
国家自然科学基金面上项目，2020.01-2023.12，58万，主持
北京市自然科学基金面上项目，2018.01-2020.12， 20万，主持
国家自然科学基金青年科学基金，2017.01-2019.12， 22万，主持
中国农业大学基本科研业务费，2023.1.1-2023.10.30，5万，主持
中国农业大学科研创新专项基金，2012.01-2013.12， 4万，主持
国家自然科学基金面上项目，2018.01-2021.12，55万，骨干
国家自然科学基金重大研究计划重点项目，2018.01-2021.12，300万，骨干
国家杰出青年科学基金，2021.01-2025.12，400万，骨干
国家自然科学基金优秀青年科学基金项目，2016.01-2018.12, 150万，骨干
科技部国家重点研发计划，2017.07-2022.06，1157万，参与
中国科学院重点部署项目，2015.05-2017.12, 190万，骨干
近期论文
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Sun SY, Fang B, Wang R, Ren FZ, Chen J*. ERV: a promising new target for lung adenocarcinoma treatment. Science bulletin. 2023 (In press)
Sun LJ, Lv Z, Chen XX, Ye R, Tian S, Wang CF, Xie XM, Yan L, Yao XH, Cui S, Chen J*, Liu JL*. SRSF1-mediated alternative splicing of Tial1/Tiar is essential for homing and self-renewal in mouse spermatogonial stem cells. Elife. 2023 12:RP89316
Sun LJ#, Chen J#, Ye R, Lv Z, Chen XX, Xie XM, Li YH, Wang CF, Lv PB, Yan L, Tian S, Yao XH, Chen C, Cui S, Liu JL*. SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice. Science bulletin. 2023 Apr 26; S2095-9273(23) (Cover story and Research highlight)
Han YX, Wu H, Sun SY, Zhao R, Deng YF, Zeng SM, Chen J*. Effect of high fat diet on disease development of polycystic ovary syndrome and lifestyle intervention strategies. Nutrients. 2023 15(9): 2230.
Sun SY, Han YX, Lei YM, Yu YF, Dong YB, Chen J*. Hematopoietic stem cell: regulation and nutritional intervention. Nutrients. 2023 15(11): 2605.
Xiong W, Fang B, Wang XY; Zhang M; Du M; Sun JZ; Chen J; Li YX; Sun CH; Lei XG; Zhang X, Ren FZ*. Dietary lipid intervention in the prevention of brain aging. Engineering. 2023 July 4.
Liang L, Cao CC, Ji L, Cai ZK, Wang D, Ye R, Chen J, Yu XH, Zhou J, Bai ZB, Wang RY, Yang XG, Zhu P, Xue YC*. Complementary Alu sequences mediate enhancer-promoter selectivity. Nature 2023 https://doi.org/10.1038/s41586-023-06323-x.
Cai ZK, Cao CC, Ji L, Ye R, Wang D, Xia C, Wang S, Du ZC, Hu NJ, Yu XH, Chen J, Wang L,Yang XG, He SM, Xue YC*. RIC-seq for global in situ profiling of RNA - RNA spatial interactions. Nature. 2020 582(7812):432-437.
Cao CC, Cai ZK, Xiao X, Rao J, Chen J, Hu NJ, Yang MN, Xing XR, Wang YL, Li MM, Zhou B, Wang XX, Wang JW*, Xue YC*. The architecture of the SARS-CoV-2 RNA genome inside virion. Nature communications. 2021 12(1):3917.
Chen J, Cai ZK, Bai MZ, Yu XH, Zhang C, Cao CC, Hu XH, Wang L, Su RB, Wang D, Wang L, Yao YP, Ye R, Hou BD, Yu Y, Yu SY, Li JS, Xue YC*. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Research. 2018 Aug 24; 28:981-995. (Cover story)
Featured in Research Highlight: Tian M & Frederick W. Alt. Guiding a mutator in antibody diversification. Cell Research. 2018 Aug 31; 28:963-964.
Chen J, Xue YC*. Emerging roles of non-coding RNAs in epigenetic regulation. Science China Life Sciences. 2016 59(3):227-235.
Chen J, Fu R, Cui Y, Pan JR, Li YS, Zhang XX, Evans Sylvia M, Cui S, Liu JL*. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin’s effect on insulin secretion in mice. Molecular Endocrinology. 2014 Aug; 28(8):1276-90.
Chen J, Fu R, Cui Y, Li YS, Pan JR, Liu JL, Luo HS, Yin JD, Li DF*, Cui S*. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem. 2013 Apr 26;288(17):12395-405.
Zhang N, Lin JK, Chen J, Liu XF, Liu JL, Luo HS, Li YQ, Cui S*. MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein kinase 8. J Biol Chem. 2013 Apr 12;288(15):10361-73.
Li YS, Pan JR, Wei C, Chen J, Liu Y, Liu JL, Zhang XX, Evans Sylvia M, Cui Y* and Cui S*. LIM homeodomain transcription factor Isl1 directs normal pyloric development via targeting Gata3. BMC Biology. 2014 12(1):25.
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