张力圩 - 中国农业大学 - 营养与健康系（营养与健康研究院）

个人简介

2023.05-至今中国农业大学，优秀人才引进，副教授 2023.01-2023.05 广州市妇女儿童医疗中心，副研究员 2019.07-2022.12 中国科学院生物物理研究所，助理研究员 2016.08-2019.06 中国科学院生物物理研究所，博士后 2011.09-2016.06 中国农业大学，理学博士 2007.09-2011.06 大连理工大学，工学学士课题项目国家自然科学基金青年科学基金，2019.01-2021.12，H3.3及其分子伴侣 HIRA介导H2A.Z在基因组中置换的分子机制及其对基因转录和神经元干细胞分化调控的研究，27万，主持国家重点研发计划，2019.01-2021.12，染色质可塑性动态调控的蛋白质机器及其作用机理，3348万，骨干参与

研究领域

基于生物信息学，开发高通量数据挖掘的算法，探索衰老和发育相关疾病的表观遗传学和免疫学机制通过宏基因组学方法，针对益生菌、膳食纤维等功能食品，研究其调节肠道菌群和改善宿主病理状态的功能机制基于网络爬虫和数据库技术，开发营养与健康大数据平台

近期论文

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(#为共同第一作者，*为通讯作者) Qixiang Zhang#, Xuyuan Zhang#, Yalan Zhu#, Panpan Sun#, Liwei Zhang, Junxiao Ma, Yong Zhang, Lingan Zeng, Xiaohua Nie, Yina Gao, Zhaolong Li, Songqing Liu, Jizhong Lou, Ang Gao*, Liguo Zhang*, Pu Gao*. (2022). Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature. doi: 10.1038/s41586-022-05452-z. Linnan Zhang, Jianping Ma, Xiaoyang Jin, Liwei Zhang, Mengfan Zhang, Patrick Z Li, Jingyun Li, Liguo Zhang (2022). Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation. J Interferon Cytokine Res. doi: 10.1089/jir.2022.0158. Yang Yang#, Liwei Zhang#*, Chaoyang Xiong, Jun Chen, Li Wang, Zengqi Wen, Juan Yu, Ping Chen, Yanhui Xu, Jingji Jin, Yong Cai*, Guohong Li*. (2022). HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. Nucleic Acids Research. doi: 10.1093/nar/gkab1221. Haizhen Long#, Liwei Zhang#, Mengjie Lv#, Zengqi Wen#，Wenhao Zhang, Xiulan Chen, Peitao Zhang, Luyuan Chang, Caiwei Jin, Xi Wang, Fuquan Yang, Ping Chen, Raphael Margueron, Haiteng Deng, Mingzhao Zhu*, Guohong Li*. (2020). H2A.Z Facilitates Licensing and Activation of Early Replication Origins. Nature. doi: 10.1038/s41586-019-1877-9. Zengqi Wen*, Liwei Zhang, Haihe Ruan*, and Guohong Li*. (2020). Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells. Nucleic Acids Research. doi: 10.1093/nar/gkaa360. Yongzheng Li#, Boxin Xue#, Mengling Zhang#, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun*. (2021). Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency. Genome Biology. doi: 10.1186/s13059-021-02424-w. Yanhui Xiao#, Wenjing Li#, Hui Yang#, Lulu Pan, Liwei Zhang, Lu Lu, Jiwei Chen, Wei Wei, Jie Ye, Jiwen Li, Guohong Li, Yong Zhang, Minjia Tan, Jianping Ding*, Jiemin Wong*. (2021). HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Research. doi: 10.1093/nar/gkab607. Jiaotong Yang, Yue Liu, Hengyu Yan, Tian Tian, Qi You, Liwei Zhang, Wenying Xu, Zhen Su. (2018). PlantEAR: functional analysis platform for plant EAR motif-containing proteins. Frontiers in Genetics. doi: 10.3389/fgene.2018.00590. Qi You, Wenying Xu, Kang Zhang, Liwei Zhang, Xin Yi, Dongxia Yao, Chunchao Wang, Xueyan Zhang, Xinhua Zhao, Nicholas Provart, Fuguang Li, Zhen Su. (2016). ccNET: Database of co-expression networks with functional modules for diploid and polyploid Gossypium. Nucleic Acids Research. doi:10.1093/nar/gkw910. Kang Zhang, Qian Song, Qiang Wei, Chunchao Wang, Liwei Zhang, Wenying Xu, Zhen Su. (2016). Down-regulation of OsSPX1 caused semi-male sterility, resulting in reduction of grain yield in rice. Plant Biotechnology Journal. doi: 10.1111/pbi.12527. Liwei Zhang#, Jinyan Guo#, Qi You, Xin Yi, Yi Ling, WenyingXu, Jinping Hua, Zhen Su*. (2015). GraP: Platform for Functional Genomics Analysis of Gossypium raimondii. Database. doi:10.1093/database/bav047. Qi You, Liwei Zhang, Xin Yi, Zhenghai Zhang, Wengying Xu, and Zhen Su. (2015). SIFGD: Setaria italica Functional Genomics Database. Molecular Plant. doi:10.1016/j.molp.2015.02.001. Jinyan Guo, Gongyao Shi, Liwei Zhang, Wenying Xu, Yumei Wang, Zhen Su, Jinping Hua. (2015). Transcriptome analysis reveals that distinct metabolic pathways operate in salt-tolerant and salt-sensitive upland cotton varieties subjected to salinity stress. Plant Science. doi:10.1016/j.plantsci. 2015.05.013. Zhenyan Miao, Wei Xu, Daofeng Li, Xiaona Hu, Jiaxing Liu, Rongxue Zhang, Zongyong Tong, Jiangli Dong, Zhen Su, Liwei Zhang, Min Sun, Wenjie Li, Zhenglin Du, Songnian Hu, Tao Wang. (2015). De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway. BMC Genomics. doi:10.1186/s12864-015-2019-x.