个人简介
2023.6-至今 中国农业大学营养与健康系,优秀人才引进,副教授
2021.9-2023.5 中国中医科学院青蒿素研究中心,助理研究员
2017.9-2021.8 北京大学化学与分子工程学院,博士后研究
2010.9-2017.7 中国农业大学生物学院,博士
2006.9-2010.7 华中农业大学植物科技学院,本科
课题项目
国家自然科学基金,(-)-Vinigrol的不对称全合成、分子探针的制备及其作用机制研究,66万,项目批准号21977002,依托北京大学,主要参与人
国家自然科学基金,化学小分子治疗新冠病毒引发的过度炎症及损伤的临床前研究,200万,项目批准号22040102,依托北京大学,主要参与人
研究领域
化学生物学解析天然产物的蛋白靶点及作用机制
开发高活性抗衰老因子
近期论文
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(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
Zhu Y#, Zhang Y#, Zhang Q, Ma A, Zhang Y, Wang C, Tang H, Gao P, Guo Q, Xia F, Tang H*, Xu C*, Wang J*. (2022) Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells. Chem Commun (Camb). 58(64):9030-9033.(#表示共同第一作者,IF:6.065)
Zhang Y#, Zhang Q#, Chu Z#, Chen L#, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G*, Wang J* and Zhu Y*. (2022) Oridonin acts as a novel senolytics by targeting Glutathione S-Transferases to activate ROS-p38 signaling axis in senescent cells. Chem Commun (Camb). 58(95):13250-13253.(*表示通讯作者,IF:6.065)
Cai Y #, Zhou H #, Zhu Y #, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L, Chen H, Li C, Luo T* & Deng H*. (2020). Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell research. 30(7):574–589. (#表示共同第一作者,IF:46.297)
该论文获得赛诺菲-Cell Research 2020 年度杰出论文奖。
Lu S #, Zhao J #, Dong J #, Liu H #, Zhu, Y #, Li H #, Liu L, Yang Y, Sun S, Song Y, Zhao Y, She R, Luo T, Deng H*, & Peng X*. (2020). Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation. Cell research. 31(2):229-232.(#表示共同第一作者,IF:46.297)
Deng J, Kong L, Zhu Y, Pei D, Chen X, Wang Y, Qi J, Song C, Yang S, Gong Z. (2022) BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis. J Integr Plant Biol. 64(6):1264-1280. (IF:9.106)
Li J#, Jin J#, Li S#, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J*, Wang J*, Li Z*. (2022) Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Adv Sci (Weinh). 9(30):e2202706. (IF:17.521)
Tang H#, Yang T#, Chen L#, Zhang Y, Zhu Y, Wang C, Liu D, Guo Q, Cheng G, Xia F, Zhong T* and Wang J*. (2023) Surface chemistry of graphene tailoring the activity of digestive enzymes by modulating interfacial molecular interactions. J Colloid Interface Sci. 630:179-192. (IF:9.965)
Qiu L, Zhang Y, Wei G, Wang C, Zhu Y, Yang T, Chu Z, Gao P, Cheng G, Ma A, Kwan Wong Y, Zhang J, Xu C, Wang J, Tang H. (2023) How eluents define proteomic fingerprinting of protein corona on nanoparticles. J Colloid Interface Sci. 648:497-510. (IF:9.965)