El-Khamisy, Sherif - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2015 - present: Director of Research and Innovation 2014 - present: Chair of Molecular Medicine, Krebs Institute, University of Sheffield 2014 - present: Wellcome Trust Investigator, Krebs Institute, University of Sheffield 2014 - present: Lister Research Fellow, Krebs Institute, University of Sheffield 2013 - 2015: Wellcome Trust Group Leader, Genome Center, University of Sussex 2013 - 2014: Reader, Krebs Institute, University of Sheffield 2008 - 2013: Wellcome Trust Fellow, Genome Center, University of Sussex 2007 - 2008: MRC Post-doctoral Fellow, Genome Center, University of Sussex, UK 2006: Post-doctoral Fellow, Dept. of Genetics, St Jude Children’s Research Hospital, USA 2005: Lecturer, Dept. of Biochemistry, Ain Shams University, Egypt 2002 - 2005: PhD in Biochemistry, University of Sussex, UK

研究领域

Mammalian genome stability in health and disease. Head of the human DNA repair group aiming to understand how defects in repairing DNA damage cause degenerative disorders, cancer and ageing.

近期论文

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Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE & El-Khamisy SF (2016) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.. Nucleic Acids Res. View this article in WRRO Elsayed W, El-Shafie L, Hassan MK, Farag MA & El-Khamisy SF (2016) Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. Scientific Reports, 6, 26626-26626. View this article in WRRO Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang S-C, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL & Loizou JI (2016) A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 15(4), 893-908. View this article in WRRO Shawky SM, Awad AM, Allam W, Alkordi MH & EL-Khamisy SF (2016) Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. Biosensors and Bioelectronics. View this article in WRRO Ashour ME, Atteya R & El-Khamisy SF (2015) Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nature Reviews Cancer, 15(3), 137-151. Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE & El-Khamisy SF (2015) Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan. Molecular Cancer Therapeutics, 14(2), 575-585. Carroll J, Page TKW, Chiang S-C, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M & El-Khamisy SF (2015) Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24(3), 828-840. View this article in WRRO Alagoz M, Wells OS & El-Khamisy SF (2014) TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Research, 42(5), 3089-3103. View this article in WRRO